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Leak current, even with gigaohm seals, can cause misinterpretation of stem cell-derived cardiomyocyte action potential recordings Journal article
Alexander P Clark, Michael Clerx, Siyu Wei, Chon Lok Lei, Teun P de Boer, Gary R Mirams, David J Christini, Trine Krogh-Madsen. Leak current, even with gigaohm seals, can cause misinterpretation of stem cell-derived cardiomyocyte action potential recordings[J]. EUROPACE, 2023, 25(9), euad243.
Authors:  Alexander P Clark;  Michael Clerx;  Siyu Wei;  Chon Lok Lei;  Teun P de Boer; et al.
Favorite | TC[WOS]:4 TC[Scopus]:5  IF:7.9/6.3 | Submit date：2023/09/04
Arrhythmias  Computer Simulation  Induced Pluripotent Stem Cells  Ion Channels  Patch Clamp  
Model-driven optimal experimental design for calibrating cardiac electrophysiology models Journal article
Lei,Chon Lok, Clerx,Michael, Gavaghan,David J., Mirams,Gary R.. Model-driven optimal experimental design for calibrating cardiac electrophysiology models[J]. Computer Methods and Programs in Biomedicine, 2023, 240, 107690.
Authors:  Lei,Chon Lok;  Clerx,Michael;  Gavaghan,David J.;  Mirams,Gary R.
Favorite | TC[WOS]:5 TC[Scopus]:5  IF:4.9/5.5 | Submit date：2023/08/03
Action Potential  Electrophysiology  Mathematical Modelling  Model Calibration  Optimal Experimental Design  Patch Clamp  
Importance of modelling hERG binding in predicting drug-induced action potential prolongations for drug safety assessment Journal article
Farm,Hui Jia, Clerx,Michael, Cooper,Fergus, Polonchuk,Liudmila, Wang,Ken, Gavaghan,David J., Lei,Chon Lok. Importance of modelling hERG binding in predicting drug-induced action potential prolongations for drug safety assessment[J]. Frontiers in Pharmacology, 2023, 14, 1110555.
Authors:  Farm,Hui Jia;  Clerx,Michael;  Cooper,Fergus;  Polonchuk,Liudmila;  Wang,Ken; et al.
Favorite | TC[WOS]:2 TC[Scopus]:2  IF:4.4/5.0 | Submit date：2023/08/03
Drug Binding  Drug Trapping  Ic50 (50% Inhibition Concentration)  Mathematical Modelling  Herg Channel  Action Potential Predictions  
Autocorrelated measurement processes and inference for ordinary differential equation models of biological systems Journal article
Lambert, Ben, Lei, Chon Lok, Robinson, Martin, Clerx, Michael, Creswell, Richard, Ghosh, Sanmitra, Tavener, Simon, Gavaghan, David J.. Autocorrelated measurement processes and inference for ordinary differential equation models of biological systems[J]. Journal of the Royal Society Interface, 2023, 20(199), 20220725.
Authors:  Lambert, Ben;  Lei, Chon Lok;  Robinson, Martin;  Clerx, Michael;  Creswell, Richard; et al.
Favorite | TC[WOS]:6 TC[Scopus]:6  IF:3.7/4.0 | Submit date：2023/03/06
Autocorrelation  Bayesian Statistics  Fisher Information  Inference  Measurement Error  Ordinary Differential Equations  
A nonlinear and time-dependent leak current in the presence of calcium fluoride patch-clamp seal enhancer Journal article
Lei, Chon Lok, Fabbri, Alan, Whittaker, Dominic G., Clerx, Michael, Windley, Monique J., Hill, Adam P., Mirams, Gary R., de Boer, Teun P.. A nonlinear and time-dependent leak current in the presence of calcium fluoride patch-clamp seal enhancer[J]. Wellcome Open Research, 2021, 5, 152.
Authors:  Lei, Chon Lok;  Fabbri, Alan;  Whittaker, Dominic G.;  Clerx, Michael;  Windley, Monique J.; et al.
Favorite | TC[Scopus]:5 | Submit date：2021/11/30
Automated Patch  Electrophysiology  Leak Current  Patch Clamp  Seal Enhancer