English | 繁體

Search in the results

UM

Browse/Search Results:  1-5 of 5 Help

Selected(0)Clear Items/Page:    Sort:
The impact of uncertainty in hERG binding mechanism on in silico predictions of drug-induced proarrhythmic risk Journal article
Lei, Chon Lok, Whittaker, Dominic G., Mirams, Gary R.. The impact of uncertainty in hERG binding mechanism on in silico predictions of drug-induced proarrhythmic risk[J]. British Journal of Pharmacology, 2024, 181(7), 987-1004.
Authors:  Lei, Chon Lok;  Whittaker, Dominic G.;  Mirams, Gary R.
Favorite | TC[WOS]:2 TC[Scopus]:1  IF:6.8/7.4 | Submit date：2024/02/22
Binding Mechanism  Cipa  Herg  Mathematical Modelling  Proarrhythmic Risk  Safety Pharmacology  Torsade  
Model-driven optimal experimental design for calibrating cardiac electrophysiology models Journal article
Lei,Chon Lok, Clerx,Michael, Gavaghan,David J., Mirams,Gary R.. Model-driven optimal experimental design for calibrating cardiac electrophysiology models[J]. Computer Methods and Programs in Biomedicine, 2023, 240, 107690.
Authors:  Lei,Chon Lok;  Clerx,Michael;  Gavaghan,David J.;  Mirams,Gary R.
Favorite | TC[WOS]:5 TC[Scopus]:5  IF:4.9/5.5 | Submit date：2023/08/03
Action Potential  Electrophysiology  Mathematical Modelling  Model Calibration  Optimal Experimental Design  Patch Clamp  
Importance of modelling hERG binding in predicting drug-induced action potential prolongations for drug safety assessment Journal article
Farm,Hui Jia, Clerx,Michael, Cooper,Fergus, Polonchuk,Liudmila, Wang,Ken, Gavaghan,David J., Lei,Chon Lok. Importance of modelling hERG binding in predicting drug-induced action potential prolongations for drug safety assessment[J]. Frontiers in Pharmacology, 2023, 14, 1110555.
Authors:  Farm,Hui Jia;  Clerx,Michael;  Cooper,Fergus;  Polonchuk,Liudmila;  Wang,Ken; et al.
Favorite | TC[WOS]:2 TC[Scopus]:2  IF:4.4/5.0 | Submit date：2023/08/03
Drug Binding  Drug Trapping  Ic50 (50% Inhibition Concentration)  Mathematical Modelling  Herg Channel  Action Potential Predictions  
Novel hybrid extreme learning machine and multi-objective optimization algorithm for air pollution prediction Journal article
Lu Bai, Zhi Liu, Jianzhou Wang. Novel hybrid extreme learning machine and multi-objective optimization algorithm for air pollution prediction[J]. Applied Mathematical Modelling, 2022, 106, 177-198.
Authors:  Lu Bai;  Zhi Liu;  Jianzhou Wang
Favorite | TC[WOS]:17 TC[Scopus]:19  IF:4.4/4.2 | Submit date：2022/05/13
Data Decomposition  Deterministic And Interval Predictions  Hybrid Prediction Model  Improved Extreme Learning Machine  Mathematical Modelling  Multi-objective Optimization Approach  
Neural Network Differential Equations For Ion Channel Modelling Journal article
Lei, Chon Lok, Mirams, Gary R.. Neural Network Differential Equations For Ion Channel Modelling[J]. Frontiers in Physiology, 2021, 12, 708944.
Authors:  Lei, Chon Lok;  Mirams, Gary R.
Favorite | TC[WOS]:5 TC[Scopus]:4  IF:3.2/4.0 | Submit date：2021/11/30
Differential Equations  Electrophysiology  Human Ether-à-go-go-related Gene  Ion Channels  Mathematical Modelling  Model Discrepancy  Neural Networks  Neural Odes