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The impact of uncertainty in hERG binding mechanism on in silico predictions of drug-induced proarrhythmic risk Journal article
Lei, Chon Lok, Whittaker, Dominic G., Mirams, Gary R.. The impact of uncertainty in hERG binding mechanism on in silico predictions of drug-induced proarrhythmic risk[J]. British Journal of Pharmacology, 2024, 181(7), 987-1004.
Authors:  Lei, Chon Lok;  Whittaker, Dominic G.;  Mirams, Gary R.
Favorite | TC[WOS]:2 TC[Scopus]:1  IF:6.8/7.4 | Submit date：2024/02/22
Binding Mechanism  Cipa  Herg  Mathematical Modelling  Proarrhythmic Risk  Safety Pharmacology  Torsade  
Empirical Quantification of Predictive Uncertainty Due to Model Discrepancy by Training with an Ensemble of Experimental Designs: An Application to Ion Channel Kinetics Journal article
Shuttleworth, Joseph G., Lei, Chon Lok, Whittaker, Dominic G., Windley, Monique J., Hill, Adam P., Preston, Simon P., Mirams, Gary R.. Empirical Quantification of Predictive Uncertainty Due to Model Discrepancy by Training with an Ensemble of Experimental Designs: An Application to Ion Channel Kinetics[J]. Bulletin of Mathematical Biology, 2024, 86(1), 2.
Authors:  Shuttleworth, Joseph G.;  Lei, Chon Lok;  Whittaker, Dominic G.;  Windley, Monique J.;  Hill, Adam P.; et al.
Favorite | TC[WOS]:2 TC[Scopus]:4  IF:2.0/2.1 | Submit date：2024/02/22
Discrepancy  Experimental Design  Ion Channel  Mathematical Model  Misspecification  Uncertainty Quantification  
A nonlinear and time-dependent leak current in the presence of calcium fluoride patch-clamp seal enhancer Journal article
Lei, Chon Lok, Fabbri, Alan, Whittaker, Dominic G., Clerx, Michael, Windley, Monique J., Hill, Adam P., Mirams, Gary R., de Boer, Teun P.. A nonlinear and time-dependent leak current in the presence of calcium fluoride patch-clamp seal enhancer[J]. Wellcome Open Research, 2021, 5, 152.
Authors:  Lei, Chon Lok;  Fabbri, Alan;  Whittaker, Dominic G.;  Clerx, Michael;  Windley, Monique J.; et al.
Favorite | TC[Scopus]:5 | Submit date：2021/11/30
Automated Patch  Electrophysiology  Leak Current  Patch Clamp  Seal Enhancer