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A new invertebrate NPY-like polypeptide, ZoaNPY, from the Zoanthus sociatus, as a novel ligand of human NPY Y2 receptor rescues vascular insufficiency via PLC/PKC and Src- FAK-dependent signaling pathways Journal article
Chen, Qian, Xu, Nan, Zhao, Chen, He, Yulin, Kam, Sandy Hio Tong, Wu, Xue, Huang, Pan, Yang, Min, Wong, Clarence Tsun Ting, Radis-Baptista, Gandhi, Tang, Benqin, Fan, Guangyi, Gong, Guiyi, Lee, Simon Ming Yuen. A new invertebrate NPY-like polypeptide, ZoaNPY, from the Zoanthus sociatus, as a novel ligand of human NPY Y2 receptor rescues vascular insufficiency via PLC/PKC and Src- FAK-dependent signaling pathways[J]. Pharmacological Research, 2024, 203, 107173.
Authors:  Chen, Qian;  Xu, Nan;  Zhao, Chen;  He, Yulin;  Kam, Sandy Hio Tong; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:9.1/9.0 | Submit date：2024/05/16
Angiogenesis  Cnidarian  Invertebrate Neuropeptide y  Npy Y2r  Transcriptome  
Tetramethylpyrazine Nitrone Promotes the Clearance of Alpha-Synuclein via Nrf2-Mediated Ubiquitin–Proteasome System Activation Journal article
Guo, Baojian, Zheng, Chengyou, Cao, Jie, Qiu, Xiaoling, Luo, Fangcheng, Li, Haitao, Lee, Simon Mingyuan, Yang, Xifei, Zhang, Gaoxiao, Sun, Yewei, Zhang, Zaijun, Wang, Yuqiang. Tetramethylpyrazine Nitrone Promotes the Clearance of Alpha-Synuclein via Nrf2-Mediated Ubiquitin–Proteasome System Activation[J]. NeuroMolecular Medicine, 2024, 26(1), 9.
Authors:  Guo, Baojian;  Zheng, Chengyou;  Cao, Jie;  Qiu, Xiaoling;  Luo, Fangcheng; et al.
Favorite | TC[WOS]:1 TC[Scopus]:1  IF:3.3/3.6 | Submit date：2024/05/16
Nuclear Factor Erythroid-2-related Factor 2  Parkinson’s Disease  Peroxisome Proliferator-activated Receptor γ Co-activator 1α  Tetramethylpyrazine Nitrone  Ubiquitin–proteasome System  Α-synuclein  
A natural small molecule aspidosperma-type alkaloid, hecubine, as a new TREM2 activator for alleviating lipopolysaccharide-induced neuroinflammation in vitro and in vivo Journal article
Li, Lin, He, Yu Lin, Xu, Nan, Wang, Xiu Fen, Song, Bing, Tang, Ben Qin, Lee, Simon Ming Yuen. A natural small molecule aspidosperma-type alkaloid, hecubine, as a new TREM2 activator for alleviating lipopolysaccharide-induced neuroinflammation in vitro and in vivo[J]. Redox Biology, 2024, 70, 103057.
Authors:  Li, Lin;  He, Yu Lin;  Xu, Nan;  Wang, Xiu Fen;  Song, Bing; et al.
Favorite | TC[WOS]:2 TC[Scopus]:2  IF:10.7/11.7 | Submit date：2024/05/02
Anti-neuroinflammation  Anti-oxidation  Aspidosperma-type Alkaloids  Hecubine  Microglia  Trem2  
Medicinal plants and natural products for treating overactive bladder Review article
2024
Authors:  Chen, Huanxian;  Hoi, Maggie Pui Man;  Lee, Simon Ming Yuen
Favorite | TC[WOS]:1 TC[Scopus]:1  IF:5.3/5.5 | Submit date：2024/05/16
Medicinal Plants  Natural Products  Overactive Bladder  
J24335 exerts neuroprotective effects against 6-hydroxydopamine-induced lesions in PC12 cells and mice Journal article
Pan, Zhijian, Shao, Min, Zhao, Chen, Yang, Xuanjun, Li, Haitao, Cui, Guozhen, Liang, Xiaonan, Yu, Chao Wu, Ye, Qingqing, Gao, Cheng, Di, Lijun, Chern, Ji Wang, Zhou, Hefeng, Lee, Simon Ming Yuen. J24335 exerts neuroprotective effects against 6-hydroxydopamine-induced lesions in PC12 cells and mice[J]. European Journal of Pharmaceutical Sciences, 2024, 194, 106696.
Authors:  Pan, Zhijian;  Shao, Min;  Zhao, Chen;  Yang, Xuanjun;  Li, Haitao; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:4.3/4.2 | Submit date：2024/04/02
6-ohda  J24335  Mitochondria Dysfunction  Neurotoxicity  Parkinson's Disease  Target Prediction  
Medulla Tetrapanacis water extract alleviates inflammation and infection by regulating macrophage polarization through MAPK signaling pathway Journal article
Kwok,Carsten Tsun Ka, Chow,Franklin Wang Ngai, Cheung,Karry Yuen Ching, Zhang,Xiao Yi, Mok,Daniel Kam Wah, Kwan,Yiu Wa, Chan,Gabriel Hoi Huen, Leung,George Pak Heng, Cheung,Ka Wang, Lee,Simon Ming Yuen, Wang,Ning, Li,Jing Jing, Seto,Sai Wang. Medulla Tetrapanacis water extract alleviates inflammation and infection by regulating macrophage polarization through MAPK signaling pathway[J]. INFLAMMOPHARMACOLOGY, 2024, 32(1), 393-404.
Authors:  Kwok,Carsten Tsun Ka;  Chow,Franklin Wang Ngai;  Cheung,Karry Yuen Ching;  Zhang,Xiao Yi;  Mok,Daniel Kam Wah; et al.
Favorite | TC[WOS]:4 TC[Scopus]:3  IF:4.6/4.5 | Submit date：2023/08/03
Anti-bacterial  Inflammation  Macrophage Polarization  Mapk Signaling Pathway  Mastitis  Medulla Tetrapanacis  
Targeted therapies of inflammatory diseases with intracellularly gelated macrophages in mice and rats Journal article
Gao, Cheng, Wang, Qingfu, Ding, Yuanfu, Kwong, Cheryl H.T., Liu, Jinwei, Xie, Beibei, Wei, Jianwen, Lee, Simon M.Y., Mok, Greta S.P., Wang, Ruibing. Targeted therapies of inflammatory diseases with intracellularly gelated macrophages in mice and rats[J]. Nature Communications, 2024, 15(1), 328.
Authors:  Gao, Cheng;  Wang, Qingfu;  Ding, Yuanfu;  Kwong, Cheryl H.T.;  Liu, Jinwei; et al.
Favorite | TC[WOS]:8 TC[Scopus]:8  IF:14.7/16.1 | Submit date：2024/05/16
Antagonizing pathological α-synuclein-mediated neurodegeneration by J24335 via the activation of immunoproteasome Journal article
Pan, Zhijian, Yu, Chao Wu, Zhao, Chen, Shao, Min, Yang, Xuanjun, Liang, Xiaonan, Li, Haitao, Lu, Yucong, Ye, Qingqing, Chern, Ji Wang, Lu, Jiahong, Zhou, Hefeng, Lee, Simon Ming Yuen. Antagonizing pathological α-synuclein-mediated neurodegeneration by J24335 via the activation of immunoproteasome[J]. Toxicology and Applied Pharmacology, 2023, 480, 116745.
Authors:  Pan, Zhijian;  Yu, Chao Wu;  Zhao, Chen;  Shao, Min;  Yang, Xuanjun; et al.
Favorite | TC[WOS]:1 TC[Scopus]:1  IF:3.3/3.6 | Submit date：2024/01/02
Immunoproteasome  J24335  Lmp7  Parkinson's Disease  Protein Degradation  Α-synuclein  
6-benzylaminopurine causes endothelial dysfunctions to human umbilical vein endothelial cells and exacerbates atorvastatin-induced cerebral hemorrhage in zebrafish Journal article
Gong, Guiyi, Kam, Hiotong, Bai, Yubin, Cheang, Wai San, Wu, Shuilong, Cheng, Xiaoning, Giesy, John P., Lee, Simon Ming-yuen. 6-benzylaminopurine causes endothelial dysfunctions to human umbilical vein endothelial cells and exacerbates atorvastatin-induced cerebral hemorrhage in zebrafish[J]. Environmental Toxicology, 2023, 39(3), 1258-1268.
Authors:  Gong, Guiyi;  Kam, Hiotong;  Bai, Yubin;  Cheang, Wai San;  Wu, Shuilong; et al.
Favorite | TC[WOS]:1 TC[Scopus]:1  IF:4.4/4.2 | Submit date：2023/11/07
6-benzylaminopurine  Huvecs  Mapk Pathway  Cerebral Hemorrhage  Endothelial Toxicity  
A bacterially engineered macrophage sponge as a neutralization decoy to treat bacterial infection Journal article
Gao, Cheng, Kwong, Cheryl H.T., Tang, Mian, Liu, Jinwei, Kam, Hiotong, Li, Shengke, Lee, Simon M.Y., Fan, Chunhai, Yu, Hua Zhong, Wang, Ruibing. A bacterially engineered macrophage sponge as a neutralization decoy to treat bacterial infection[J]. Matter, 2023, 6(11), 3889-3911.
Authors:  Gao, Cheng;  Kwong, Cheryl H.T.;  Tang, Mian;  Liu, Jinwei;  Kam, Hiotong; et al.
Favorite | TC[WOS]:10 TC[Scopus]:11  IF:17.3/18.9 | Submit date：2023/12/04
Bacterial Infection  Cell Engineering  Hydrogel  Macrophage Sponge  Map6: Development  Neutralizing Agent