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A bacterially engineered macrophage sponge as a neutralization decoy to treat bacterial infection
Gao, Cheng1; Kwong, Cheryl H.T.1; Tang, Mian1; Liu, Jinwei1; Kam, Hiotong1; Li, Shengke1; Lee, Simon M.Y.1; Fan, Chunhai2; Yu, Hua Zhong3; Wang, Ruibing1
2023-10-06
Source PublicationMatter
ISSN2590-2393
Volume6Issue:11Pages:3889-3911
Abstract

Antibiotic-resistant strains have emerged, and endotoxins vary greatly in their structural motifs across bacterial species, limiting the clearance efficiency of structure-specific anti-endotoxin antibodies. This study constructs intracellularly gelated macrophages (GMs) with an intact membrane structure to neutralize bacteria and endotoxins via receptor-ligand interaction and share the bacterial burden to ameliorate in vivo infection without considering their molecular structure. Furthermore, GMs derived from bacterially infected macrophages (here referred to as bacterially engineered macrophages) are found to have upregulated membrane pathogen-related receptors for strengthened bacterium and endotoxin recognition and increased the membrane zeta potential to reduce the electrostatic repulsion force for facile GM-bacterium surface interaction. Bacterially engineered GMs achieve efficient management of sepsis and wound infection and targeted alleviation of bacterial pneumonia. The top-down fabrication of GMs provides a universal neutralization strategy against bacterial infection, and bacterially engineered host immune cells, upon intracellular gelation, demonstrate a natural cell engineering venue to obtain comprehensive neutralization decoys.

KeywordBacterial Infection Cell Engineering Hydrogel Macrophage Sponge Map6: Development Neutralizing Agent
DOI10.1016/j.matt.2023.09.007
URLView the original
Indexed BySCIE
Language英語English
Scopus ID2-s2.0-85174567281
Fulltext Access
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Document TypeJournal article
CollectionMinistry of Education Frontiers Science Center for Precision Oncology, University of Macau
Institute of Chinese Medical Sciences
THE STATE KEY LABORATORY OF QUALITY RESEARCH IN CHINESE MEDICINE (UNIVERSITY OF MACAU)
Corresponding AuthorWang, Ruibing
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, MoE Frontiers Science Center for Precision Oncology, University of Macau, Taipa, Macau SAR, 999078, China
2.School of Chemistry and Chemical Engineering, MoE Frontiers Science Center for Transformative Molecules, National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai, 200240, China
3.Department of Chemistry, Simon Fraser University, Burnaby, V5A 1S6, Canada
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Gao, Cheng,Kwong, Cheryl H.T.,Tang, Mian,et al. A bacterially engineered macrophage sponge as a neutralization decoy to treat bacterial infection[J]. Matter, 2023, 6(11), 3889-3911.
APA Gao, Cheng., Kwong, Cheryl H.T.., Tang, Mian., Liu, Jinwei., Kam, Hiotong., Li, Shengke., Lee, Simon M.Y.., Fan, Chunhai., Yu, Hua Zhong., & Wang, Ruibing (2023). A bacterially engineered macrophage sponge as a neutralization decoy to treat bacterial infection. Matter, 6(11), 3889-3911.
MLA Gao, Cheng,et al."A bacterially engineered macrophage sponge as a neutralization decoy to treat bacterial infection".Matter 6.11(2023):3889-3911.
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