Residential College | false |
Status | 已發表Published |
A bacterially engineered macrophage sponge as a neutralization decoy to treat bacterial infection | |
Gao, Cheng1; Kwong, Cheryl H.T.1; Tang, Mian1; Liu, Jinwei1; Kam, Hiotong1; Li, Shengke1; Lee, Simon M.Y.1; Fan, Chunhai2; Yu, Hua Zhong3; Wang, Ruibing1 | |
2023-10-06 | |
Source Publication | Matter |
ISSN | 2590-2393 |
Volume | 6Issue:11Pages:3889-3911 |
Abstract | Antibiotic-resistant strains have emerged, and endotoxins vary greatly in their structural motifs across bacterial species, limiting the clearance efficiency of structure-specific anti-endotoxin antibodies. This study constructs intracellularly gelated macrophages (GMs) with an intact membrane structure to neutralize bacteria and endotoxins via receptor-ligand interaction and share the bacterial burden to ameliorate in vivo infection without considering their molecular structure. Furthermore, GMs derived from bacterially infected macrophages (here referred to as bacterially engineered macrophages) are found to have upregulated membrane pathogen-related receptors for strengthened bacterium and endotoxin recognition and increased the membrane zeta potential to reduce the electrostatic repulsion force for facile GM-bacterium surface interaction. Bacterially engineered GMs achieve efficient management of sepsis and wound infection and targeted alleviation of bacterial pneumonia. The top-down fabrication of GMs provides a universal neutralization strategy against bacterial infection, and bacterially engineered host immune cells, upon intracellular gelation, demonstrate a natural cell engineering venue to obtain comprehensive neutralization decoys. |
Keyword | Bacterial Infection Cell Engineering Hydrogel Macrophage Sponge Map6: Development Neutralizing Agent |
DOI | 10.1016/j.matt.2023.09.007 |
URL | View the original |
Indexed By | SCIE |
Language | 英語English |
Scopus ID | 2-s2.0-85174567281 |
Fulltext Access | |
Citation statistics | |
Document Type | Journal article |
Collection | Ministry of Education Frontiers Science Center for Precision Oncology, University of Macau Institute of Chinese Medical Sciences THE STATE KEY LABORATORY OF QUALITY RESEARCH IN CHINESE MEDICINE (UNIVERSITY OF MACAU) |
Corresponding Author | Wang, Ruibing |
Affiliation | 1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, MoE Frontiers Science Center for Precision Oncology, University of Macau, Taipa, Macau SAR, 999078, China 2.School of Chemistry and Chemical Engineering, MoE Frontiers Science Center for Transformative Molecules, National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai, 200240, China 3.Department of Chemistry, Simon Fraser University, Burnaby, V5A 1S6, Canada |
First Author Affilication | Institute of Chinese Medical Sciences |
Corresponding Author Affilication | Institute of Chinese Medical Sciences |
Recommended Citation GB/T 7714 | Gao, Cheng,Kwong, Cheryl H.T.,Tang, Mian,et al. A bacterially engineered macrophage sponge as a neutralization decoy to treat bacterial infection[J]. Matter, 2023, 6(11), 3889-3911. |
APA | Gao, Cheng., Kwong, Cheryl H.T.., Tang, Mian., Liu, Jinwei., Kam, Hiotong., Li, Shengke., Lee, Simon M.Y.., Fan, Chunhai., Yu, Hua Zhong., & Wang, Ruibing (2023). A bacterially engineered macrophage sponge as a neutralization decoy to treat bacterial infection. Matter, 6(11), 3889-3911. |
MLA | Gao, Cheng,et al."A bacterially engineered macrophage sponge as a neutralization decoy to treat bacterial infection".Matter 6.11(2023):3889-3911. |
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