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Identification of JAZF1, KNOP1, and PLEKHA1 as causally associated genes and drug targets for Alzheimer’s disease: a summary data-based Mendelian randomization study Journal article
Zhai, Yuhan, Li, Ning, Zhang, Yujie, Li, Haibin, Wu, Lijuan, Wei, Cuibai, Ji, Jianguang, Zheng, Deqiang. Identification of JAZF1, KNOP1, and PLEKHA1 as causally associated genes and drug targets for Alzheimer’s disease: a summary data-based Mendelian randomization study[J]. Inflammopharmacology, 2024, 32(6), 3913-3923.
Authors:  Zhai, Yuhan;  Li, Ning;  Zhang, Yujie;  Li, Haibin;  Wu, Lijuan; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:4.6/4.5 | Submit date：2024/11/05
Alzheimer’s Disease  Causal Association  Immune Cells  Summary-data-based Mendelian Randomization  
An integrated strategy for in-depth profiling of N-acylethanolamines in biological samples by UHPLC-HRMS Journal article
Zhou, Jun Yi, Chen, Yan Qing, Hu, Guang, Zhao, Haiyu, Wan, Jian Bo. An integrated strategy for in-depth profiling of N-acylethanolamines in biological samples by UHPLC-HRMS[J]. Analytica Chimica Acta, 2024, 1329, 343262.
Authors:  Zhou, Jun Yi;  Chen, Yan Qing;  Hu, Guang;  Zhao, Haiyu;  Wan, Jian Bo
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:5.7/5.5 | Submit date：2024/10/10
Alzheimer's Disease  Chemical Derivatization  N-acylethanolamides  Parallel Reaction Monitoring  Uhplc-hrms  
Artemisinin inhibits neuronal ferroptosis in Alzheimer's disease models by targeting KEAP1 Journal article
Peng-xi Deng, Marta Silva, Na Yang, Qing Wang, Xin Meng, Ke-qiang Ye, Hong-chang Gao, ZHENG WENHUA. Artemisinin inhibits neuronal ferroptosis in Alzheimer's disease models by targeting KEAP1[J]. Acta Pharmacologica Sinica, 2024.
Authors:  Peng-xi Deng;  Marta Silva;  Na Yang;  Qing Wang;  Xin Meng; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:6.9/7.6 | Submit date：2024/08/31
Alzheimer's Disease  Artemisinin  Ferroptosis  Keap1  Nrf2  Hippocampus  
Sigma-1 receptor positive allosteric modulator promotes the neuronal survival and improves cognitive deficits in AD mice via Sigma-1 receptor/ERK pathway Conference paper
Xiaoyu Wang, Wenhua Zheng. Sigma-1 receptor positive allosteric modulator promotes the neuronal survival and improves cognitive deficits in AD mice via Sigma-1 receptor/ERK pathway[C], 2024.
Authors:  Xiaoyu Wang;  Wenhua Zheng
Favorite |  | Submit date：2024/08/31
Alzheimer's Disease, Somcl-668, Neuronal Cells, 3xtg-ad Mice, Sigma-1 Receptor/erk/creb Pathway  
Artemisinin protects against neural injury by targeting KEAP1 to inhibit ferroptosis in Alzheimer’s disease models Conference paper
Pengxi DENG, ZHENG WENHUA. Artemisinin protects against neural injury by targeting KEAP1 to inhibit ferroptosis in Alzheimer’s disease models[C], 2024.
Authors:  Pengxi DENG;  ZHENG WENHUA
Favorite |  | Submit date：2024/08/31
Artemisinin, Ferroptosis, Keap1, Nrf2, Alzheimer's Disease (Ad).  
Artemisinin Alleviates Astrocyte Over-Activation and Neuroinflammation by modulating the IRE1/NF-κB Signaling Pathway in in vitro and in vivo Alzheimer's Disease Models Conference paper
Lei Chen, ZHENG WENHUA. Artemisinin Alleviates Astrocyte Over-Activation and Neuroinflammation by modulating the IRE1/NF-κB Signaling Pathway in in vitro and in vivo Alzheimer's Disease Models[C], 2024.
Authors:  Lei Chen;  ZHENG WENHUA
Favorite |  | Submit date：2024/08/31
Alzheimer’s Disease  Endoplasmic Reticulum Stress  Artemisinin  Astrocyte  3xtg Ad Mice  Neuroinflammation  Ire1  Nf-κb.  
Artemisinin diminished the hyperphosphorylation of Tau induced by Aβ1-42 via the AKT/GSK-3β pathway in vitro and in vivo Alzheimer's disease modle Conference paper
Yitian Chen, Wenhua Zheng. Artemisinin diminished the hyperphosphorylation of Tau induced by Aβ1-42 via the AKT/GSK-3β pathway in vitro and in vivo Alzheimer's disease modle[C], 2024.
Authors:  Yitian Chen;  Wenhua Zheng
Favorite |  | Submit date：2024/08/31
Alzheimer’s Disease, Aβ, Tau Hyperphosphorylation, Artemisinin, Gsk-3β, P13k/akt  
P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting p-tau217 with immunotherapy ameliorates murine tauopathy Journal article
Zhang, Denghong, Zhang, Wei, Ming, Chen, Gao, Xuheng, Yuan, Huilong, Lin, Xiaojie, Mao, Xinru, Wang, Chunping, Guo, Xiaoyi, Du, Ying, Shao, Lin, Yang, Renzhi, Lin, Zhihao, Wu, Xilin, Huang, Timothy Y., Wang, Zhanxiang, Zhang, Yun wu, Xu, Huaxi, Zhao, Yingjun. P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting p-tau217 with immunotherapy ameliorates murine tauopathy[J]. Neuron, 2024, 112(10), 1676-1693.e12.
Authors:  Zhang, Denghong;  Zhang, Wei;  Ming, Chen;  Gao, Xuheng;  Yuan, Huilong; et al.
Favorite | TC[WOS]:4 TC[Scopus]:4  IF:14.7/16.9 | Submit date：2024/05/16
Alzheimer's Disease  Cell Death  Cognitive Impairment  Immunotherapy  Motor Dysfunction  Neurodegeneration  Neurodegenerative Disease  P-tau217  Tau  Tauopathy  
Dual-target inhibitors of cholinesterase and GSK-3β to modulate Alzheimer's disease Other
2024-04-01
Authors:  He, Junqiu;  Tam, Kin Yip
Favorite | TC[WOS]:2 TC[Scopus]:3 | Submit date：2024/05/02
Alzheimer's Disease  Cholinesterase  Drug Design Strategy  Dual-target Inhibitors  Gsk-3β  
Dual-target inhibitors of cholinesterase and GSK-3beta to modulate Alzheimer's disease Journal article
He Junqiu, TAM KIN YIP. Dual-target inhibitors of cholinesterase and GSK-3beta to modulate Alzheimer's disease[J]. Drug Discovery Today, 2024, 29(4), 1-8.
Authors:  He Junqiu;  TAM KIN YIP
Adobe PDF | Favorite | TC[WOS]:2 TC[Scopus]:3  IF:6.5/7.3 | Submit date：2024/08/29
Gsk-3b  Cholinesterase  Dual-target Inhibitors  Alzheimer’s Disease  Drug Design Strategy