| Residential College | false |
| Status | 已發表Published |
| Dual-target inhibitors of cholinesterase and GSK-3beta to modulate Alzheimer's disease | |
He Junqiu; TAM KIN YIP 
| |
| 2024-04 | |
| Source Publication | Drug Discovery Today
 |
| ISSN | 1359-6446 |
| Volume | 29Issue:4Pages:1-8 |
| Abstract | Alzheimer’s disease (AD) is a neurodegenerative disease that affects over 55 million patients worldwide. Most of the approved small-molecule drugs for AD have been designed to tackle a single pathological hallmark, such as cholinergic dysfunction or amyloid toxicity, and thus may not fully address the multifactorial nature of the disease. Inhibition of both cholinesterase and glycogen synthase kinase-3b (GSK-3b) has emerged as a promising strategy to modulate AD. However, the dual inhibition of these two targets posts challenges in molecular design: issues related to target engagements and biopharmaceutical properties in particular must be overcome. In this review, we discuss the physiopathological roles and structures of cholinesterase and GSK-3b as well as recently reported dual-target inhibitors. We critically evaluate the current status of the discovery of dual-target inhibitors of cholinesterase and GSK-3b, and highlight further perspectives. |
| Keyword | Gsk-3b Cholinesterase Dual-target Inhibitors Alzheimer’s Disease Drug Design Strategy |
| DOI | 10.1016/j.drudis.2024.103914 |
| URL | View the original |
| Indexed By | SCIE |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | DEPARTMENT OF PHARMACEUTICAL SCIENCES |
| Corresponding Author | TAM KIN YIP |
| Affiliation | Faculty of Health Sciences |
| Recommended Citation GB/T 7714 | He Junqiu,TAM KIN YIP. Dual-target inhibitors of cholinesterase and GSK-3beta to modulate Alzheimer's disease[J]. Drug Discovery Today, 2024, 29(4), 1-8. |
| APA | He Junqiu., & TAM KIN YIP (2024). Dual-target inhibitors of cholinesterase and GSK-3beta to modulate Alzheimer's disease. Drug Discovery Today, 29(4), 1-8. |
| MLA | He Junqiu,et al."Dual-target inhibitors of cholinesterase and GSK-3beta to modulate Alzheimer's disease".Drug Discovery Today 29.4(2024):1-8. |
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| File Name/Size | Publications | Version | Access | License | ||
| 1-s2.0-S135964462400（1910KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Download | |
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