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Novel Dichloroacetophenone-Based PDHK1 Inhibitors as Potent Anticancer Agents Journal article
Wu, Puhua, Zhang, Zhicheng, Zhou, Yan, Liu, Quan, Tam, Kin Yip, Su, Zhenhong. Novel Dichloroacetophenone-Based PDHK1 Inhibitors as Potent Anticancer Agents[J]. DRUG DESIGN DEVELOPMENT AND THERAPY, 2024, 18, 4661-4679.
Authors:  Wu, Puhua;  Zhang, Zhicheng;  Zhou, Yan;  Liu, Quan;  Tam, Kin Yip; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:4.7/4.8 | Submit date：2024/11/05
Pdhk1  Dichloroacetophenone  Allosteric Pocket  Anti-nsclc Activity  Tumor Xenograft Mouse Model  
Exploring casual effects and shared molecular mechanism between psoriasis and liver cancer through Mendelian randomization and comprehensive bioinformatic analyses Journal article
Ran, Maoxin, Sha, Ou, Tam, Kin Yip. Exploring casual effects and shared molecular mechanism between psoriasis and liver cancer through Mendelian randomization and comprehensive bioinformatic analyses[J]. Computational Biology and Chemistry, 2024, 110, 108089.
Authors:  Ran, Maoxin;  Sha, Ou;  Tam, Kin Yip
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:2.6/2.6 | Submit date：2024/05/16
Causal Relationship  Gene Signature  Liver Cancer  Psoriasis  Rank Conservation  Shared Molecular Mechanism  
ALS-linked C9orf72 dipeptide repeats inhibit starvation-induced autophagy through modulating BCL2–BECN1 interaction Journal article
Xu, Shiqiang, Ma, Qilian, Shen, Junwen, Li, Ningning, Sun, Shan, Wang, Nana, Chen, Yang, Dong, Chunsheng, Tam, Kin Yip, Prehn, Jochen H.M., Wang, Hongfeng, Ying, Zheng. ALS-linked C9orf72 dipeptide repeats inhibit starvation-induced autophagy through modulating BCL2–BECN1 interaction[J]. Acta Pharmaceutica Sinica B, 2024, 14(5), 2026-2038.
Authors:  Xu, Shiqiang;  Ma, Qilian;  Shen, Junwen;  Li, Ningning;  Sun, Shan; et al.
Favorite | TC[WOS]:0 TC[Scopus]:1  IF:14.7/14.1 | Submit date：2024/05/16
Amyotrophic Lateral Sclerosis  Autophagy  Bcl2  Becn1/beclin 1  C9orf72  Dipeptide Repeat  Frontotemporal Dementia  Neurodegeneration  
Dual-target inhibitors of cholinesterase and GSK-3beta to modulate Alzheimer's disease Journal article
He Junqiu, TAM KIN YIP. Dual-target inhibitors of cholinesterase and GSK-3beta to modulate Alzheimer's disease[J]. Drug Discovery Today, 2024, 29(4), 1-8.
Authors:  He Junqiu;  TAM KIN YIP
Adobe PDF | Favorite | TC[WOS]:2 TC[Scopus]:3  IF:6.5/7.3 | Submit date：2024/08/29
Gsk-3b  Cholinesterase  Dual-target Inhibitors  Alzheimer’s Disease  Drug Design Strategy  
Dual-target inhibitors of cholinesterase and GSK-3β to modulate Alzheimer's disease Other
2024-04-01
Authors:  He, Junqiu;  Tam, Kin Yip
Favorite | TC[WOS]:2 TC[Scopus]:3 | Submit date：2024/05/02
Alzheimer's Disease  Cholinesterase  Drug Design Strategy  Dual-target Inhibitors  Gsk-3β  
Combined inhibition of pyruvate dehydrogenase kinase 1 and hexokinase 2 induces apoptsis in non-small cell lung cancer cell models Journal article
Guo, Yizhen, Lu, Xianchen, Zhou, Yan, Chen, Wen Hua, Tam, Kin Yip. Combined inhibition of pyruvate dehydrogenase kinase 1 and hexokinase 2 induces apoptsis in non-small cell lung cancer cell models[J]. Experimental Cell Research, 2023, 433(2), 113830.
Authors:  Guo, Yizhen;  Lu, Xianchen;  Zhou, Yan;  Chen, Wen Hua;  Tam, Kin Yip
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:3.3/3.3 | Submit date：2024/01/02
Cancer Metabolism  Combination Therapy  Hk2  Nsclc  Pdk1  
Combined inhibition of pyruvate dehydrogenase kinase 1 and lactate dehydrogenase a induces metabolic and signaling reprogramming and enhances lung adenocarcinoma cell killing Journal article
Zhou, Yan, Guo, Yizhen, Ran, Maoxin, Shan, Wenying, Granchi, Carlotta, Giovannetti, Elisa, Minutolo, Filippo, Peters, Godefridus J., Tam, Kin Yip. Combined inhibition of pyruvate dehydrogenase kinase 1 and lactate dehydrogenase a induces metabolic and signaling reprogramming and enhances lung adenocarcinoma cell killing[J]. Cancer Letters, 2023, 577, 216425.
Authors:  Zhou, Yan;  Guo, Yizhen;  Ran, Maoxin;  Shan, Wenying;  Granchi, Carlotta; et al.
Favorite | TC[WOS]:9 TC[Scopus]:7  IF:9.1/8.3 | Submit date：2023/12/04
Anticancer  Combination Treatment  Non-small Cell Lung Cancer  Warburg Effect  
Chlorpromazine affects autophagy in association with altered Rag GTPase–mTORC1–TFEB signaling Journal article
Li, Ningning, Rao, Lingling, Zhao, Xueqing, Shen, Junwen, Su, Dan, Ma, Guoqiang, Sun, Shan, Ma, Qilian, Zhang, Li, Dong, Chunsheng, Tam, Kin Yip, Prehn, Jochen H.M., Wang, Hongfeng, Ying, Zheng. Chlorpromazine affects autophagy in association with altered Rag GTPase–mTORC1–TFEB signaling[J]. Frontiers in Cell and Developmental Biology, 2023, 11, 1266198.
Authors:  Li, Ningning;  Rao, Lingling;  Zhao, Xueqing;  Shen, Junwen;  Su, Dan; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:4.6/5.2 | Submit date：2024/02/22
Autophagy  Cpz  Mtorc1  Rag Gtpases  Tfeb  
Dichloroacetophenone derivatives as pyruvate dehydrogenase kinase inhibitor in non-small cell lung cancer models Presentation
会议地点: University Rectorate, Belgrade, Serbia, 会议日期: 4-6 September, 2023, 报告日期: 2023-09-05
Authors:  TAM KIN YIP
Favorite |  | Submit date：2024/08/30
Cancer Metabolism  Aerobic Glycolysis  Pyruvate Dehydrogenase Kinase  
Epigallocatechin gallate circumvents drug induced resistance in non-small cell lung cancer by modulating glucose metabolism and AMPK/AKT/MAPK axis Journal article
Zhou, Yan, Huang, Shiqi, Guo, Yizhen, Ran, Maxoin, Shan, Wenying, Wen-Hau Chen, Tam, Kin Yip. Epigallocatechin gallate circumvents drug induced resistance in non-small cell lung cancer by modulating glucose metabolism and AMPK/AKT/MAPK axis[J]. Phytotheraphy Research, 2023, 37(12), 5837-5853.
Authors:  Zhou, Yan;  Huang, Shiqi;  Guo, Yizhen;  Ran, Maxoin;  Shan, Wenying; et al.
Favorite | TC[WOS]:6 TC[Scopus]:7  IF:6.1/7.0 | Submit date：2023/08/22
Acquired Drug Resistance  Combination Therapy  Egcg  Egfr-tkis  Nsclc  Synergetic Effect