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GSK3β 抑制剂和/或 HRR 抑制剂在制备治疗 FHIT 缺失型肺癌的药物中的应用 Patent
专利类型: 发明专利 Invention, 专利号: UMPT0737-2024, 申请日期: 2024-08,
Authors:  JOONG SUP SHIM;  SHISHI TAO
Adobe PDF | Favorite |  | Submit date：2024/08/29
BET inhibition induces synthetic lethality in PTEN deficient colorectal cancers via dual action on p21CIP1/WAF1 Journal article
Ren, Guowen, Chen, Jinghong, Pu, Yue, Yang, Eun Ju, Tao, Shishi, Mou, Pui Kei, Chen, Li Jie, Zhu, Wenli, Chan, Kin Long, Luo, Guanghui, Deng, Chuxia, Shim, Joong Sup. BET inhibition induces synthetic lethality in PTEN deficient colorectal cancers via dual action on p21CIP1/WAF1[J]. International Journal of Biological Sciences, 2024, 20(6), 1978-1991.
Authors:  Ren, Guowen;  Chen, Jinghong;  Pu, Yue;  Yang, Eun Ju;  Tao, Shishi; et al.
Favorite | TC[WOS]:1 TC[Scopus]:1  IF:8.2/8.3 | Submit date：2024/05/16
Akt  Bet  Colorectal Cancer  Myc  P21  PhosphorylAted P21 At Thr145  Pten  Synthetic Lethality  
BRCA1 Insufficiency Induces a Hypersialylated Acidic Tumor Microenvironment That Promotes Metastasis and Immunotherapy Resistance Journal article
Xiaodong Shu, Jianjie Li, Un In Chan, Sek Man Su, Changxiang Shi, Xin Zhang, Tingting An, Jun Xu, Lihua Mo, Jianlin Liu, Yuqing Wang, Xiaoling Li, Min Deng, Josh Haipeng Lei, Chunfei Wang, Hao Tian, Sun Heng, Joong Sup Shim, Xuanjun Zhang, Yunlu Dai, Zhicheng Yao, Xiaying Kuang, Ying Lin, Chu-Xia Deng, Xiaoling Xu. BRCA1 Insufficiency Induces a Hypersialylated Acidic Tumor Microenvironment That Promotes Metastasis and Immunotherapy Resistance[J]. CANCER RESEARCH, 2023, 83(15), 2614-2633.
Authors:  Xiaodong Shu;  Jianjie Li;  Un In Chan;  Sek Man Su;  Changxiang Shi; et al.
Favorite | TC[WOS]:2 TC[Scopus]:2  IF:12.5/11.6 | Submit date：2023/08/30
ER translocon inhibitor ipomoeassin F inhibits triple-negative breast cancer growth via blocking ER molecular chaperones Journal article
Shishi Tao, Eun Ju Yang, Guanghui Zong, Pui Kei Mou, Guowen Ren, Yue Pu, Liang Chen, Ho Jeong Kwon, Jianhong Zhou, Zhijian Hu, Arman Khosravi, Qingyang Zhang, Yuchun Du, Wei Q. Shi, Joong Sup Shim. ER translocon inhibitor ipomoeassin F inhibits triple-negative breast cancer growth via blocking ER molecular chaperones[J]. Int J Biol Sci, 2023, 19(13), 4020-4035.
Authors:  Shishi Tao;  Eun Ju Yang;  Guanghui Zong;  Pui Kei Mou;  Guowen Ren; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:8.2/8.3 | Submit date：2023/08/30
Ipomoeassin f  Er Stress  Er Translocon  Tnbc  Pdia6  Pdia4  
MDM2 inhibition is synthetic lethal with PTEN loss in colorectal cancer cells via the p53-dependent mechanism Journal article
Guowen Ren, Eun Ju Yang, Shishi Tao, Pui Kei Mou, Yue Pu, Li-Jie Chen, Joong Sup Shim. MDM2 inhibition is synthetic lethal with PTEN loss in colorectal cancer cells via the p53-dependent mechanism[J]. Int J Biol Sci, 2023, 19(11), 3544-3557.
Authors:  Guowen Ren;  Eun Ju Yang;  Shishi Tao;  Pui Kei Mou;  Yue Pu; et al.
Favorite |   IF:8.2/8.3 | Submit date：2023/08/30
Aurora A kinase inhibition compromises its antitumor efficacy by elevating PD-L1 expression Journal article
Wang, Xiaobo, Huang, Jing, Liu, Fenglin, Yu, Qian, Wang, Ruina, Wang, Jiaqi, Zhu, Zewen, Yu, Juan, Hou, Jun, Shim, Joong Sup, Jiang, Wei, Li, Zengxia, Zhang, Yuanyuan, Dang, Yongjun. Aurora A kinase inhibition compromises its antitumor efficacy by elevating PD-L1 expression[J]. Journal of Clinical Investigation, 2023, 133(9), e161929.
Authors:  Wang, Xiaobo;  Huang, Jing;  Liu, Fenglin;  Yu, Qian;  Wang, Ruina; et al.
Favorite | TC[WOS]:16 TC[Scopus]:18  IF:13.3/14.6 | Submit date：2023/06/05
TRIM59 guards ER proteostasis and prevents Bortezomib-mediated colorectal cancer (CRC) cells’ killing Journal article
Xuejia Feng, Gui Yang, Litian Zhang, Shishi Tao, Joong Sup SHIM, Liang Chen, Qingxia Wu. TRIM59 guards ER proteostasis and prevents Bortezomib-mediated colorectal cancer (CRC) cells’ killing[J]. INVESTIGATIONAL NEW DRUGS, 2022, 40(6), 1244-1253.
Authors:  Xuejia Feng;  Gui Yang;  Litian Zhang;  Shishi Tao;  Joong Sup SHIM; et al.
Favorite | TC[WOS]:3 TC[Scopus]:3  IF:3.0/2.9 | Submit date：2023/01/30
Trim59  Er-stress  Unfolded Protein Response  Er-associated Degradation  Bortezomib  Colorectal Cancer  
Targeting DNA methyltransferases (DNMT) in von-Hippel Lindau (VHL)-deficient renal cell carcinoma Project
项目类型: General Scientific Research Funding, 项目编号: 0049/2022/A, 资助机构: FDCT, 2022-2025
Authors:  JOONG SUP SHIM
Favorite |  | Submit date：2023/03/29
Small Activating RNA Modulation of the G Protein-Coupled Receptor for Cancer Treatment Journal article
Xiong, Yunfang, Ke, Ran, Zhang, Qingyu, Lan, Wenjun, Yuan, Wanjun, Chan, Karol Nga Ieng, Roussel, Tom, Jiang, Yifan, Wu, Jing, Liu, Shuai, Wong, Alice Sze Tsai, Shim, Joong Sup, Zhang, Xuanjun, Xie, Ruiyu, Dusetti, Nelson, Iovanna, Juan, Habib, Nagy, Peng, Ling, Lee, Leo Tsz On. Small Activating RNA Modulation of the G Protein-Coupled Receptor for Cancer Treatment[J]. Advanced Science, 2022, 9(26).
Authors:  Xiong, Yunfang;  Ke, Ran;  Zhang, Qingyu;  Lan, Wenjun;  Yuan, Wanjun; et al.
Favorite | TC[WOS]:13 TC[Scopus]:15  IF:14.3/16.3 | Submit date：2022/08/05
Cancer Therapies  Dendrimer Vectors  g Protein-coupled Receptors  Mas Receptors (Mas1s)  Small Activating Rna  
TRIM family proteins: roles in proteostasis and neurodegenerative diseases Review article
2022
Authors:  Zhu, Yan;  Afolabi, LO;  Wan, Xiaochun;  Shim, Joong Sup;  Chen, Liang
Favorite | TC[WOS]:18 TC[Scopus]:17  IF:4.5/5.9 | Submit date：2022/08/31
Neurodegenerative Diseases  Trim Proteins  Protein Aggregation  Proteostasis  Ubiquitin-proteasome System  Chaperone