| Residential College | false |
| Patent Number | UMPT0737-2024 |
| Status | 申請中 Pending |
| GSK3β 抑制剂和/或 HRR 抑制剂在制备治疗 FHIT 缺失型肺癌的药物中的应用 | |
| Year Issued | 2024 |
| 2024-08 | |
| Application Number | 202411058434.7 |
| Application Date | 2024-08 |
JOONG SUP SHIM  ; SHISHI TAO
| |
| Country | CHINA |
| Subtype | 发明专利 Invention |
| Abstract | 本发明公开了GSK3β抑制剂和/或HRR抑制剂在制备治疗FHIT缺失型肺癌的药物中的应用。本发明首次发现糖原合成酶激酶3β（GSK3β）和同源重组DNA 修复（HRR）通路是肺癌中FHIT的合成致死标靶；抑制GSK3β或HRR通路，包括ATR/BRCA1/RAD51轴，可显著抑制FHIT缺失肺癌细胞中的DNA双链断裂修复，导致DNA损伤累积和细胞凋亡；为GSK3β和HRR通路作为FHIT缺失型肺癌可行药物靶点提供了依据。而且，本申请进一步研究了在非FHIT缺失肺癌中，同时抑制FHIT和GSK3β/ HRR，仍会导致细胞产生合成致死，进一步扩展了应用方向。 |
| Language | 中文Chinese |
| Document Type | Patent |
| Collection | DEPARTMENT OF PHARMACEUTICAL SCIENCES |
| Corresponding Author | JOONG SUP SHIM |
| Affiliation | Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China |
| First Author Affilication | Faculty of Health Sciences |
| Recommended Citation GB/T 7714 | JOONG SUP SHIM,SHISHI TAO. GSK3β 抑制剂和/或 HRR 抑制剂在制备治疗 FHIT 缺失型肺癌的药物中的应用. UMPT0737-2024[P]. 2024-08-01. |
| APA | JOONG SUP SHIM., & SHISHI TAO (2024-08). GSK3β 抑制剂和/或 HRR 抑制剂在制备治疗 FHIT 缺失型肺癌的药物中的应用. |
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