This chapter presents a new approach to hysteresis modeling and compensation of piezoelectric actuators by resorting to an intelligent model. A least squares support vector machine (LSSVM)-based hysteresis model is developed and used for the purposes of both hysteresis characterization and compensation. By this way, the hysteresis inverse is not needed in the feedforward hysteresis compensator since only the hysteresis model is used. The effectiveness of the presented approach is validated by experimental studies on a piezoactuated system. Experimental results confirm that this approach is superior to Bouc-Wen model in terms of both hysteresis modeling and compensation.