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The prevalence of painful physical symptoms in major depressive disorder: A systematic review and meta-analysis of observational studies
Liu, Zi Han1,2,3; Jin, Yu4; Rao, Wen Wang1,2,3; Zhang, Qinge5; Zhang, Juan6; Jackson, Todd7; Su, Zhaohui8; Xiang, Yu Tao1,2,3
2021-06-05
Source PublicationProgress in Neuro-Psychopharmacology and Biological Psychiatry
ISSN0278-5846
Volume111Pages:110372
Abstract

Background: Painful physical symptoms (PPS) are common in patients with major depressive disorder (MDD), but their prevalence has been mixed. This is a systematic review and meta-analysis of the pooled prevalence of PPS in MDD patients. Methods: Systematic literature searches were independently conducted in major databases (PubMed, EMBASE, PsycINFO and Web of Science). Data analyses were conducted using a random-effects model. Results: A total of 20 studies with 53,852 patients were included. The overall prevalence of PPS in MDD patients was 55.2% (95%CI: 47.9–62.3%), with a point prevalence of 64.2% (95%CI: 53.2–73.8%) and a 12-month prevalence of 57.0% (95%CI: 23.9–84.8%). No significant publication bias was found in this meta-analysis. Conclusion: PPS are common in MDD patients. Considering the negative impact of PPS on daily functioning, effective preventive measures and routine screening should be conducted for MDD patients, and timely treatments should be offered to those in need. 

KeywordMajor Depressive Disorder Meta-analysis Painful Physical Symptoms Prevalence
DOI10.1016/j.pnpbp.2021.110372
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaNeurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS SubjectClinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS IDWOS:000826967300001
Scopus ID2-s2.0-85108099602
Fulltext Access
Citation statistics
Document TypeJournal article
CollectionDEPARTMENT OF PUBLIC HEALTH AND MEDICINAL ADMINISTRATION
Faculty of Education
Faculty of Health Sciences
Faculty of Social Sciences
DEPARTMENT OF PSYCHOLOGY
INSTITUTE OF COLLABORATIVE INNOVATION
INSTITUTE OF ADVANCED STUDIES IN HUMANITIES AND SOCIAL SCIENCES
Institute of Translational Medicine
Co-First AuthorLiu, Zi Han
Corresponding AuthorXiang, Yu Tao
Affiliation1.Unit of Psychiatry, Department of Public Health and Medicinal Administration, & Institute of Translational Medicine, University of Macau, Macao SAR, China
2.Centre for Cognitive and Brain Sciences, University of Macau, Macao SAR, China
3.Institute of Advanced Studies in Humanities and Social Sciences, University of Macau, Macao SAR, China
4.College of Education for the Future, Beijing Normal University, China
5.The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital & the Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
6.Faculty of Education, University of Macau, Macao SAR, China
7.Department of Psychology, University of Macau, Macao SAR, China
8.Center on Smart and Connected Health Technologies, Mays Cancer Center, School of Nursing, San Antonio, UT Health San Antonio, United States
First Author AffilicationUniversity of Macau
Corresponding Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Liu, Zi Han,Jin, Yu,Rao, Wen Wang,et al. The prevalence of painful physical symptoms in major depressive disorder: A systematic review and meta-analysis of observational studies[J]. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2021, 111, 110372.
APA Liu, Zi Han., Jin, Yu., Rao, Wen Wang., Zhang, Qinge., Zhang, Juan., Jackson, Todd., Su, Zhaohui., & Xiang, Yu Tao (2021). The prevalence of painful physical symptoms in major depressive disorder: A systematic review and meta-analysis of observational studies. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 111, 110372.
MLA Liu, Zi Han,et al."The prevalence of painful physical symptoms in major depressive disorder: A systematic review and meta-analysis of observational studies".Progress in Neuro-Psychopharmacology and Biological Psychiatry 111(2021):110372.
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