Active suspension is an effective approach to improve vehicle performance, and it is of great importance to attenuate the vibration of the rear part of heavy vehicles with freight. This paper proposes a new hybrid fuzzy proportional-integral-derivative (PID) controller with model adaptive wheelbase preview and wavelet denoising filter in an active suspension system for heavy vehicles with freight. A half vehicle model is first built, followed with the construction of the road excitation profiles of the shock and vibration pavement. After the design and implementation of the control method, four performance indices of the vehicle are evaluated. To verify the effectiveness of the proposed method, the control performance of the integrated controller and the separate function of every single controller are evaluated respectively. Numerical results show that the integrated control algorithm is superior to the single controllers and is effective in improving the vehicle performance as compared with other methods. Moreover, the wavelet denoising filter is shown to be an effective way to improve the vehicle performance and enable the stability of the system against noise.