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Selective intrafascicular stimulation of myelinated and unmyelinated nerve fibers through a longitudinal electrode: A computational study
Wang, Xintong1; Zhang, Yapeng1; Guo, Tianruo2; Wu, Shuhui1; Zhong, Junwen3; Cheng, Chengkung1,4; Sui, Xiaohong1
2024-06-01
Source PublicationComputers in Biology and Medicine
ISSN0010-4825
Volume176Pages:108556
Abstract

Carbon nanotube (CNT) fiber electrodes have demonstrated exceptional spatial selectivity and sustained reliability in the context of intrafascicular electrical stimulation, as evidenced through rigorous animal experimentation. A significant presence of unmyelinated C fibers, known to induce uncomfortable somatosensory experiences, exists within peripheral nerves. This presence poses a considerable challenge to the excitation of myelinated Aβ fibers, which are crucial for tactile sensation. To achieve nuanced tactile sensory feedback utilizing CNT fiber electrodes, the selective stimulation of Aβ sensory afferents emerges as a critical factor. In confronting this challenge, the present investigation sought to refine and apply a rat sciatic-nerve model leveraging the capabilities of the COMSOL-NEURON framework. This approach enables a systematic evaluation of the influence exerted by stimulation parameters and electrode geometry on the activation dynamics of both myelinated Aβ and unmyelinated C fibers. The findings advocate for the utilization of current pulses featuring a pulse width of 600 μs, alongside the deployment of CNT fibers characterized by a diminutive diameter of 10 μm, with an exclusively exposed cross-sectional area, to facilitate reduced activation current thresholds. Comparative analysis under monopolar and bipolar electrical stimulation conditions revealed proximate activation thresholds, albeit with bipolar stimulation exhibiting superior fiber selectivity relative to its monopolar counterpart. Concerning pulse waveform characteristics, the adoption of an anodic-first biphasic stimulation modality is favored, taking into account the dual criteria of activation threshold and fiber selectivity optimization. Consequently, this investigation furnishes an efficacious stimulation paradigm for the selective activation of touch-related nerve fibers, alongside provisioning a comprehensive theoretical foundation for the realization of natural tactile feedback within the domain of prosthetic hand applications.

KeywordComputational Modeling Intrafascicular Electrical Stimulation Longitudinal Electrode Peripheral Nerve Selective Activation Unmyelinated c Fiber
DOI10.1016/j.compbiomed.2024.108556
URLView the original
Language英語English
PublisherElsevier Ltd
Scopus ID2-s2.0-85192674964
Fulltext Access
Citation statistics
Document TypeJournal article
CollectionFaculty of Science and Technology
DEPARTMENT OF ELECTROMECHANICAL ENGINEERING
Corresponding AuthorSui, Xiaohong
Affiliation1.School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China
2.Graduate School of Biomedical Engineering, The University of New South Wales, Sydney, 2052, Australia
3.Department of Electromechanical Engineering, University of Macau, Macau SAR, 999078, China
4.Med-X Research Institute, Shanghai Jiao Tong University, Engineering Research Center of Digital Medicine, Ministry of Education, Shanghai, China
Recommended Citation
GB/T 7714
Wang, Xintong,Zhang, Yapeng,Guo, Tianruo,et al. Selective intrafascicular stimulation of myelinated and unmyelinated nerve fibers through a longitudinal electrode: A computational study[J]. Computers in Biology and Medicine, 2024, 176, 108556.
APA Wang, Xintong., Zhang, Yapeng., Guo, Tianruo., Wu, Shuhui., Zhong, Junwen., Cheng, Chengkung., & Sui, Xiaohong (2024). Selective intrafascicular stimulation of myelinated and unmyelinated nerve fibers through a longitudinal electrode: A computational study. Computers in Biology and Medicine, 176, 108556.
MLA Wang, Xintong,et al."Selective intrafascicular stimulation of myelinated and unmyelinated nerve fibers through a longitudinal electrode: A computational study".Computers in Biology and Medicine 176(2024):108556.
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