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Versatile magnetic hydrogel soft capsule microrobots for targeted delivery
Xu, Zichen1; Wu, Zehao1; Yuan, Mingzhe2; Chen, Yuanhe1; Ge, Wei2; Xu, Qingsong1
2023-04-25
Source PublicationiScience
ISSN2589-0042
Volume26Issue:5Pages:106727
Other Abstract

Maintaining the completeness of cargo and achieving on-demand cargo release during long navigations in complex environments of the internal human body is crucial. Herein, we report a novel design of magnetic hydrogel soft capsule microrobots, which can be physically disintegrated to release microrobot swarms and diverse cargoes with almost no loss. CaCl2 solution and magnetic powders are utilized to produce suspension droplets, which are put into sodium alginate solution to generate magnetic hydrogel membranes for enclosing microrobot swarms and cargos. Low-density rotating magnetic fields drive the microrobots. Strong gradient magnetic fields break the mechanical structure of the hydrogel shell to implement on-demand release. Under the guidance of ultrasound imaging, the microrobot is remotely controlled in acidic or alkaline environments, similar to those in the human digestion system. The proposed capsule microrobots provide a promising solution for targeted cargo delivery in the internal human body.

KeywordBiomedical Materials Magnetic Property Robotics
DOI10.1016/j.isci.2023.106727
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:001000985500001
PublisherCELL PRESS, 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139
Scopus ID2-s2.0-85156270699
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Citation statistics
Document TypeJournal article
CollectionCentre of Reproduction, Development and Aging
Faculty of Health Sciences
DEPARTMENT OF ELECTROMECHANICAL ENGINEERING
DEPARTMENT OF BIOMEDICAL SCIENCES
Corresponding AuthorGe, Wei; Xu, Qingsong
Affiliation1.Department of Electromechanical Engineering, Faculty of Science and Technology, University of Macau, Macau, China
2.Department of Biomedical Sciences and Centre of Reproduction, Development and Aging (CRDA), Faculty of Health Sciences, University of Macau, Macau, China
First Author AffilicationFaculty of Science and Technology
Corresponding Author AffilicationCentre of Reproduction, Development and Aging;  Faculty of Science and Technology
Recommended Citation
GB/T 7714
Xu, Zichen,Wu, Zehao,Yuan, Mingzhe,et al. Versatile magnetic hydrogel soft capsule microrobots for targeted delivery[J]. iScience, 2023, 26(5), 106727.
APA Xu, Zichen., Wu, Zehao., Yuan, Mingzhe., Chen, Yuanhe., Ge, Wei., & Xu, Qingsong (2023). Versatile magnetic hydrogel soft capsule microrobots for targeted delivery. iScience, 26(5), 106727.
MLA Xu, Zichen,et al."Versatile magnetic hydrogel soft capsule microrobots for targeted delivery".iScience 26.5(2023):106727.
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