The development of contemporary teacher education in Macao has been dynamic and unique, and can be dated back to the late 1930s. It was mainly affected by the social and political changes in Mainland China, particularly the Guangdong Province. Since then, teacher education has developed, though in a non-linear mode, accompanied by a series of political changes and educational reforms in Macao, especially prior to, and after, the political handover to the People’s Republic of China in 1999. Owing to this historical context, teacher education in Macao has shared three distinctive features. First, there are diverse routes of pre-service teacher preparation, including different types, formats and programmes provided by educational institutions recognized by the local government either established in Macao or outside. Second, it has been shaped, to a large extent, by the social and political developments of Macao. Third, it has been strongly influenced by regional/national policy, and by the intense pursuit of repositioning Macao into the global arena. This chapter elaborates on these features, and further discusses the current practices, future trends and challenges of teacher education in Macao, especially taking into account the recent establishment of the Guangdong-Hong Kong-Macao Greater Bay Area and the emergence of neoliberal policies across all fields of education.