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Novel C. elegans models of Lewy body disease reveal pathological protein interactions and widespread miRNA dysregulation Journal article
Li, Rongzhen, Huang, Xiaobing, Shen, Linjing, Zhang, Tianjiao, Liu, Ning, Hou, Xiangqing, Wong, Garry. Novel C. elegans models of Lewy body disease reveal pathological protein interactions and widespread miRNA dysregulation[J]. Cellular and Molecular Life Sciences, 2024, 81(1), 377.
Authors:  Li, Rongzhen;  Huang, Xiaobing;  Shen, Linjing;  Zhang, Tianjiao;  Liu, Ning; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:6.2/7.7 | Submit date：2024/10/10
Amyloid β  Parkinson’s Disease  Tar-dna-binding Protein 43  Tau Protein  Α-synuclein  
Artemisinin diminished the hyperphosphorylation of Tau induced by Aβ1-42 via the AKT/GSK-3β pathway in vitro and in vivo Alzheimer's disease modle Conference paper
Yitian Chen, Wenhua Zheng. Artemisinin diminished the hyperphosphorylation of Tau induced by Aβ1-42 via the AKT/GSK-3β pathway in vitro and in vivo Alzheimer's disease modle[C], 2024.
Authors:  Yitian Chen;  Wenhua Zheng
Favorite |  | Submit date：2024/08/31
Alzheimer’s Disease, Aβ, Tau Hyperphosphorylation, Artemisinin, Gsk-3β, P13k/akt  
P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting p-tau217 with immunotherapy ameliorates murine tauopathy Journal article
Zhang, Denghong, Zhang, Wei, Ming, Chen, Gao, Xuheng, Yuan, Huilong, Lin, Xiaojie, Mao, Xinru, Wang, Chunping, Guo, Xiaoyi, Du, Ying, Shao, Lin, Yang, Renzhi, Lin, Zhihao, Wu, Xilin, Huang, Timothy Y., Wang, Zhanxiang, Zhang, Yun wu, Xu, Huaxi, Zhao, Yingjun. P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting p-tau217 with immunotherapy ameliorates murine tauopathy[J]. Neuron, 2024, 112(10), 1676-1693.e12.
Authors:  Zhang, Denghong;  Zhang, Wei;  Ming, Chen;  Gao, Xuheng;  Yuan, Huilong; et al.
Favorite | TC[WOS]:4 TC[Scopus]:4  IF:14.7/16.9 | Submit date：2024/05/16
Alzheimer's Disease  Cell Death  Cognitive Impairment  Immunotherapy  Motor Dysfunction  Neurodegeneration  Neurodegenerative Disease  P-tau217  Tau  Tauopathy  
Targeting autophagy in Alzheimer’s disease: Animal models and mechanisms Journal article
Zhang, Xiao Wen, Zhu, Xiang Xing, Tang, Dong Sheng, Lu, Jia Hong. Targeting autophagy in Alzheimer’s disease: Animal models and mechanisms[J]. Zoological Research, 2023, 44(6), 1132-1145.
Authors:  Zhang, Xiao Wen;  Zhu, Xiang Xing;  Tang, Dong Sheng;  Lu, Jia Hong
Favorite | TC[WOS]:11 TC[Scopus]:10  IF:4.0/4.5 | Submit date：2024/02/22
Alzheimer’s Disease  Animal Models  Autophagy  Aβ Metabolism  Tau Pathology  
NPLC0393 from Gynostemma pentaphyllum ameliorates Alzheimer's disease-like pathology in mice by targeting protein phosphatase magnesium-dependent 1A phosphatase Journal article
Lv，Jianlu, Shen，Xingyi, Shen，Xinya, Zhao，Shimei, Xu，Rui, Yan，Qiuying, Lu，Jian, Zhu，Danyang, Zhao，Yonghua, Dong，Jiajia, Wang，Jiaying, Shen，Xu. NPLC0393 from Gynostemma pentaphyllum ameliorates Alzheimer's disease-like pathology in mice by targeting protein phosphatase magnesium-dependent 1A phosphatase[J]. Phytotherapy Research, 2023.
Authors:  Lv，Jianlu;  Shen，Xingyi;  Shen，Xinya;  Zhao，Shimei;  Xu，Rui; et al.
Favorite | TC[WOS]:3 TC[Scopus]:6  IF:6.1/7.0 | Submit date：2023/08/03
AD  Gynostemma pentaphyllum  NLRP3  NPLC0393  PPM1A  tau  
Therapeutic Mechanism of Kai Xin San on Alzheimer’s Disease Based on Network Pharmacology and Experimental Validation Journal article
Wang, Kan, Yang, Rong, Chen, Tuan tuan, Qin, Mei rong, Wang, Ping, Kong, Ming wang. Therapeutic Mechanism of Kai Xin San on Alzheimer’s Disease Based on Network Pharmacology and Experimental Validation[J]. Chinese Journal of Integrative Medicine, 2022.
Authors:  Wang, Kan;  Yang, Rong;  Chen, Tuan tuan;  Qin, Mei rong;  Wang, Ping; et al.
Favorite | TC[WOS]:4 TC[Scopus]:4  IF:2.2/2.3 | Submit date：2023/01/30
Alzheimer’s Disease  Chinese Medicine  Experimental Validation  Kai Xin San  Molecular Docking  Network Pharmacology  Tau Protein  
Impairment of the autophagy–lysosomal pathway in Alzheimer's diseases: Pathogenic mechanisms and therapeutic potential Journal article
Wei Zhang, Chengchao Xu, Jichao Sun, Han-Ming Shen, Jigang Wang, Chuanbin Yang. Impairment of the autophagy–lysosomal pathway in Alzheimer's diseases: Pathogenic mechanisms and therapeutic potential[J]. Acta Pharmaceutica Sinica B, 2022, 12(3), 1019-1040.
Authors:  Wei Zhang;  Chengchao Xu;  Jichao Sun;  Han-Ming Shen;  Jigang Wang; et al.
Favorite | TC[WOS]:82 TC[Scopus]:84  IF:14.7/14.1 | Submit date：2022/04/06
Alzheimer’s Disease (Ad)  Amyloid Beta (Ab) Peptides  Mapt/tau  Autophagy–lysosomal Pathway  Autophagy Enhancers  Autophagy  Mitophagy  Neurodegenerative Diseases  
Molecular dynamics simulations reveal the disruption mechanism of a 2,4-thiazolidinedione derivative C30 against tau hexapeptide (PHF6) oligomer Journal article
Liu, Hongli, Zhong, Haiyang, Liu, Huanxiang, Yao, Xiaojun. Molecular dynamics simulations reveal the disruption mechanism of a 2,4-thiazolidinedione derivative C30 against tau hexapeptide (PHF6) oligomer[J]. Proteins: Structure, Function and Bioinformatics, 2022, 90(1), 142-154.
Authors:  Liu, Hongli;  Zhong, Haiyang;  Liu, Huanxiang;  Yao, Xiaojun
Favorite | TC[WOS]:5 TC[Scopus]:5  IF:3.2/2.8 | Submit date：2023/01/30
2,4-thiazolidinedione Derivative  Mm-gbsa  Molecular Dynamics Simulation  Phf6  Tau  
Yuan-Hu Zhi Tong Prescription Mitigates Tau Pathology and Alleviates Memory Deficiency in the Preclinical Models of Alzheimer’s Disease Journal article
Iyaswamy,A., Krishnamoorthi,S. K., Liu,Y. W., Song,J. X., Kammala,A. K., Sreenivasmurthy,S. G., Malampati,S., Tong,B. C.K., Selvarasu,K., Cheung,K. H., Lu,J. H., Tan,J. Q., Huang,C. Y., Durairajan,S. S.K., Li,M.. Yuan-Hu Zhi Tong Prescription Mitigates Tau Pathology and Alleviates Memory Deficiency in the Preclinical Models of Alzheimer’s Disease[J]. Frontiers in Pharmacology, 2020, 11(584770).
Authors:  Iyaswamy,A.;  Krishnamoorthi,S. K.;  Liu,Y. W.;  Song,J. X.;  Kammala,A. K.; et al.
Favorite | TC[WOS]:25 TC[Scopus]:25  IF:4.4/5.0 | Submit date：2021/03/02
Alzheimer’s Disease  P301s Tau Mice  Neurofibrillary Tangles  Chinese Medicine  Yuan-hu Zhi Tong  Microarray  Connectivity Map  
A small molecule transcription factor EB activator ameliorates beta-amyloid precursor protein and Tau pathology in Alzheimer's disease models Journal article
Ju-Xian Song, Sandeep Malampati, Yu Zeng, Siva Sundara Kumar Durairajan, Chuan-Bin Yang, Benjamin Chun-Kit Tong, Ashok Iyaswamy, Wen-Bin Shang, Sreenivasmurthy,Sravan Gopalkrishnashetty, Zhou Zhu, King-Ho Cheung, Jia-Hong Lu, Chunzhi Tang, Nenggui Xu, Min Li. A small molecule transcription factor EB activator ameliorates beta-amyloid precursor protein and Tau pathology in Alzheimer's disease models[J]. AGING CELL, 2020, 19(2).
Authors:  Ju-Xian Song;  Sandeep Malampati;  Yu Zeng;  Siva Sundara Kumar Durairajan;  Chuan-Bin Yang; et al.
Favorite | TC[WOS]:106 TC[Scopus]:114  IF:8.0/9.7 | Submit date：2021/03/02
Alzheimer's Disease  Beta-amyloid  Curcumin Analog C1  Mapt/tau  Tfeb