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BET inhibition induces synthetic lethality in PTEN deficient colorectal cancers via dual action on p21CIP1/WAF1 Journal article
Ren, Guowen, Chen, Jinghong, Pu, Yue, Yang, Eun Ju, Tao, Shishi, Mou, Pui Kei, Chen, Li Jie, Zhu, Wenli, Chan, Kin Long, Luo, Guanghui, Deng, Chuxia, Shim, Joong Sup. BET inhibition induces synthetic lethality in PTEN deficient colorectal cancers via dual action on p21CIP1/WAF1[J]. International Journal of Biological Sciences, 2024, 20(6), 1978-1991.
Authors:  Ren, Guowen;  Chen, Jinghong;  Pu, Yue;  Yang, Eun Ju;  Tao, Shishi; et al.
Favorite | TC[WOS]:1 TC[Scopus]:1  IF:8.2/8.3 | Submit date：2024/05/16
Akt  Bet  Colorectal Cancer  Myc  P21  PhosphorylAted P21 At Thr145  Pten  Synthetic Lethality  
Hybrid nanoassembly indicating a synthetic lethality relationship induces mitotic catastrophe-mediated tumor elimination Journal article
Zheng, Shunzhe, Li, Guanting, Fu, Shuwen, Wang, Nannan, Qiao, Han, Li, Meng, Zhang, Xuanbo, Wang, Kaiyuan, Sun, Wei, Tian, Chutong, He, Zhonggui, Ouyang, Defang, Sun, Bingjun, Sun, Jin. Hybrid nanoassembly indicating a synthetic lethality relationship induces mitotic catastrophe-mediated tumor elimination[J]. Chemical Engineering Journal, 2024, 479, 147802.
Authors:  Zheng, Shunzhe;  Li, Guanting;  Fu, Shuwen;  Wang, Nannan;  Qiao, Han; et al.
Favorite | TC[WOS]:1 TC[Scopus]:1  IF:13.3/13.2 | Submit date：2024/02/22
Cell Cycle Checkpoints  Mitotic Catastrophe  Prodrug Nanoassembly  Synthetic Lethality  Translational Medicine  
Class I histone deacetylase inhibition is synthetic lethal with BRCA1 deficiency in breast cancer cells Journal article
Zhang,Baoyuan, Lyu,Junfang, Yang,Eun Ju, Liu,Yifan, Wu,Changjie, Pardeshi,Lakhansing, Tan,Kaeling, Chen,Qiang, Xu,Xiaoling, Deng,Chu Xia, Shim,Joong Sup. Class I histone deacetylase inhibition is synthetic lethal with BRCA1 deficiency in breast cancer cells[J]. Acta Pharmaceutica Sinica B, 2020, 10(4), 615-627.
Authors:  Zhang,Baoyuan;  Lyu,Junfang;  Yang,Eun Ju;  Liu,Yifan;  Wu,Changjie; et al.
Favorite | TC[WOS]:24 TC[Scopus]:29  IF:14.7/14.1 | Submit date：2020/09/16
Brca1  Histone Deacetylase  Hdac  Synthetic Lethality  Reactive Oxygen Species  Dna Damage  Breast Cancer  
Histone acetyltransferase (HAT) P300/CBP inhibitors induce synthetic lethality in pten-deficient colorectal cancer cells through destabilizing AKT Journal article
Liu,Yifan, Yang,Eun Ju, Shi,Changxiang, Mou,Pui Kei, Zhang,Baoyuan, Wu,Changjie, Lyu,Junfang, Shim,Joong Sup. Histone acetyltransferase (HAT) P300/CBP inhibitors induce synthetic lethality in pten-deficient colorectal cancer cells through destabilizing AKT[J]. International Journal of Biological Sciences, 2020, 16(11), 1774-1784.
Authors:  Liu,Yifan;  Yang,Eun Ju;  Shi,Changxiang;  Mou,Pui Kei;  Zhang,Baoyuan; et al.
Favorite | TC[WOS]:15 TC[Scopus]:15  IF:8.2/8.3 | Submit date：2021/03/04
Akt  Anacardic Acid  Histone Acetyltransferases  Hsp70  Pten  Synthetic Lethality  
PTEN deficiency confers colorectal cancer cell resistance to dual inhibitors of FLT3 and aurora kinase A Journal article
Yifan Liu, Eun Ju Yang, Baoyuan Zhang, Zhengqiang Miao, Changjie Wu, Junfang Lyu, Kaeling Tan, Terence Chuen Wai Poon, Joong Sup Shim. PTEN deficiency confers colorectal cancer cell resistance to dual inhibitors of FLT3 and aurora kinase A[J]. CANCER LETTERS, 2018, 436, 28-37.
Authors:  Yifan Liu;  Eun Ju Yang;  Baoyuan Zhang;  Zhengqiang Miao;  Changjie Wu; et al.
Favorite | TC[WOS]:13 TC[Scopus]:11  IF:9.1/8.3 | Submit date：2018/10/30
Akt  Kw2449  Synthetic Lethality  Aurka  Drug Combination  
Selective targeting of BRCA1 deficient breast cancer by bromodomain and extra-terminal motif (BET) inhibitors Conference paper
Zhang, B., Yang, E. J., Lyu, J., Liu, Y., Wu, C., Chen, Q., Tan, K., Wong, K. H., Xu, X., Deng, C., Shim, J. S.. Selective targeting of BRCA1 deficient breast cancer by bromodomain and extra-terminal motif (BET) inhibitors[C], 2017.
Authors:  Zhang, B.;  Yang, E. J.;  Lyu, J.;  Liu, Y.;  Wu, C.; et al.
Favorite |  | Submit date：2022/07/27
Bromodomain and extra-terminal motif  BRCA1  synthetic lethality  
Synthetic lethality by targeting Aurora A activity in ARID1A-deficient colorectal cancer cells Conference paper
Wu, C., Yang, E. J., Lyu, J., Liu, Y., Zhang, B., Tan, K., Wong, K. H., Shim, J. S.. Synthetic lethality by targeting Aurora A activity in ARID1A-deficient colorectal cancer cells[C], 2017.
Authors:  Wu, C.;  Yang, E. J.;  Lyu, J.;  Liu, Y.;  Zhang, B.; et al.
Favorite |  | Submit date：2022/07/27
ARID1A  tumor suppressor  synthetic lethality  aurora kinase A