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A NIR iridium(III) complex-based luminescence probe for imaging mitochondria pyruvate dehydrogenase kinase 1 in triple-negative breast cancer cells Journal article
Jing, Shaozhen, Song, Ying Qi, Liu, Jingqi, Zhao, Chen, Wang, Ling, Chan, Daniel Shiu Hin, Wong, Chun Yuen, Lee, Simon Ming Yuen, Wang, Jing, Leung, Chung Hang, Wang, Wanhe. A NIR iridium(III) complex-based luminescence probe for imaging mitochondria pyruvate dehydrogenase kinase 1 in triple-negative breast cancer cells[J]. Sensors and Actuators B: Chemical, 2024, 418, 136265.
Authors:  Jing, Shaozhen;  Song, Ying Qi;  Liu, Jingqi;  Zhao, Chen;  Wang, Ling; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:8.0/7.0 | Submit date：2024/08/05
Breast Cancer  Dichloroacetic Acid (Dca)  Iridium(Iii) Complex  Mitochondrial Targeting  Nir Imaging  Pyruvate Dehydrogenase Kinase 1 (Pdk1)  
Heme oxygenase 1-mediated ferroptosis in Kupffer cells initiates liver injury during heat stroke Journal article
Li, Ru, Wei, Riqing, Liu, Chenxin, Zhang, Keying, He, Sixiao, Liu, Zhifeng, Huang, Junhao, Tang, Youyong, An, Qiyuan, Lin, Ligen, Gan, Lishe, Zhao, Liying, Zou, Xiaoming, Wang, Fudi, Ping, Yuan, Ma, Qiang. Heme oxygenase 1-mediated ferroptosis in Kupffer cells initiates liver injury during heat stroke[J]. Acta Pharmaceutica Sinica B, 2024.
Authors:  Li, Ru;  Wei, Riqing;  Liu, Chenxin;  Zhang, Keying;  He, Sixiao; et al.
Favorite | TC[WOS]:2 TC[Scopus]:2  IF:14.7/14.1 | Submit date：2024/07/04
Early Growth Response Factor 1  Ferroptosis  Heat Stroke  Heme Oxygenase 1  Kupffer Cells  Liver Injury  Nlrp3  Phosphatidylinositol 4-kinase Beta  
Discovery of a potent and selective covalent threonine tyrosine kinase (TTK) inhibitor Journal article
Sun, Yaoliang, Chen, Zhiwen, Liu, Guobin, Chen, Xiaoai, Shi, Zihan, Feng, Huixu, Yu, Lei, Li, Guodong, Ding, Ke, Huang, He, Zhang, Zhang, Xu, Shilin. Discovery of a potent and selective covalent threonine tyrosine kinase (TTK) inhibitor[J]. Bioorganic Chemistry, 2023, 143, 107053.
Authors:  Sun, Yaoliang;  Chen, Zhiwen;  Liu, Guobin;  Chen, Xiaoai;  Shi, Zihan; et al.
Favorite | TC[WOS]:1 TC[Scopus]:1  IF:4.5/4.7 | Submit date：2024/02/22
Cancer  Covalent  Inhibitor  Threonine Tyrosine Kinase (Ttk)  
Dichloroacetophenone derivatives as pyruvate dehydrogenase kinase inhibitor in non-small cell lung cancer models Presentation
会议地点: University Rectorate, Belgrade, Serbia, 会议日期: 4-6 September, 2023, 报告日期: 2023-09-05
Authors:  TAM KIN YIP
Favorite |  | Submit date：2024/08/30
Cancer Metabolism  Aerobic Glycolysis  Pyruvate Dehydrogenase Kinase  
A target map of clinical combination therapies in oncology: an analysis of clinicaltrials.gov Journal article
Yang, Jing, Kang, Heming, Lyu, Liyang, Xiong, Wei, Hu, Yuanjia. A target map of clinical combination therapies in oncology: an analysis of clinicaltrials.gov[J]. Discover Oncology, 2023, 14(1), 151.
Authors:  Yang, Jing;  Kang, Heming;  Lyu, Liyang;  Xiong, Wei;  Hu, Yuanjia
Favorite | TC[WOS]:7 TC[Scopus]:7 | Submit date：2023/09/21
Bispecific Antibodies  Combination Therapy  Immuno-oncology Therapy  Kinase Inhibitors  Pd-1/pd-l1 Inhibitors  Targeted Therapy  
Anti-diabetic potential of apigenin, luteolin, and baicalein via partially activating PI3K/Akt/Glut-4 signaling pathways in insulin-resistant HepG2 cells Journal article
Miao, Lingchao, Zhang, Haolin, Cheong, Meng Sam, Zhong Ruting, Garcia-Oliveira, Paula, Prieto, Miguel A, Cheng, Ka-Wing, Wang, Mingfu, Cao, Hui, Nie, Shaoping, Simal-Gandara, Jesus, Cheang, Wai San, Xiao, Jianbo. Anti-diabetic potential of apigenin, luteolin, and baicalein via partially activating PI3K/Akt/Glut-4 signaling pathways in insulin-resistant HepG2 cells[J]. Food Science and Human Wellness, 2023, 12(6), 1991-2000.
Authors:  Miao, Lingchao;  Zhang, Haolin;  Cheong, Meng Sam;  Zhong Ruting;  Garcia-Oliveira, Paula; et al.
Favorite | TC[WOS]:23 TC[Scopus]:21  IF:5.6/6.8 | Submit date：2022/08/11
Apigenin  Luteolin  Baicalein  Insulin-resistant Hepg2 Cells  Signaling Pathway  Reactive Oxygen Species (Ros)  Advanced Glycation End-products (Ages)  Glycogen Synthase Kinase (Gsk-3β)  Glucose Transporter Protein 4 (Glut4)  
Protein Kinase C Modulation Determines the Mesoderm/ Extraembryonic Fate Under BMP4 Induction From Human Pluripotent Stem Cells Journal article
Godoy-Parejo, Carlos, Deng, Chunhao, Xu, Jiaqi, Zhang, Zhaoying, Ren, Zhili, Ai, Nana, Liu, Weiwei, Ge, Wei, Deng, Chuxia, Xu, Xiaoling, Chin, Y. Eugene, Chen, Guokai. Protein Kinase C Modulation Determines the Mesoderm/ Extraembryonic Fate Under BMP4 Induction From Human Pluripotent Stem Cells[J]. Stem Cells, 2023, 41(6), 578-591.
Authors:  Godoy-Parejo, Carlos;  Deng, Chunhao;  Xu, Jiaqi;  Zhang, Zhaoying;  Ren, Zhili; et al.
Favorite | TC[WOS]:2 TC[Scopus]:1  IF:4.0/4.9 | Submit date：2023/07/19
Bmp4  Extraembryonic  Fgf  Gf109203x  Human Embryonic Stem Cells  Mesoderm  Protein Kinase c  Signaling Boundary  Trophoblast  Wnt  
CDK inhibitors from past to present: A new wave of cancer therapy Journal article
Muhammad Jameel Mughal, Kinjal Bhadresha, Hang Fai Kwok. CDK inhibitors from past to present: A new wave of cancer therapy[J]. Seminars in Cancer Biology, 2023, 88, 106-122.
Authors:  Muhammad Jameel Mughal;  Kinjal Bhadresha;  Hang Fai Kwok
Favorite | TC[WOS]:38 TC[Scopus]:38  IF:12.1/13.2 | Submit date：2023/02/08
Cancer Therapeutic Regimen  Cell Cycle  Combination Treatment  Cyclin-dependent Kinase Inhibitor  
Dehydroeburicoic Acid, a Dual Inhibitor against Oxidative Stress in Alcoholic Liver Disease Journal article
Shasha Cheng, Yi Kuang, Guodong Li, Jia Wu, Chung-Nga Ko, Wanhe Wang, Dik-Lung Ma, Min Ye, Chung-Hang Leung. Dehydroeburicoic Acid, a Dual Inhibitor against Oxidative Stress in Alcoholic Liver Disease[J]. Pharmaceuticals, 2022, 16(1), 14.
Authors:  Shasha Cheng;  Yi Kuang;  Guodong Li;  Jia Wu;  Chung-Nga Ko; et al.
Favorite | TC[WOS]:2 TC[Scopus]:2  IF:4.3/4.6 | Submit date：2023/02/08
Alcoholic Liver Disease (Ald)  Glycogen Synthase Kinase 3β (Gsk3β)  Hepatoprotective  Keap1–nrf2 Protein–protein Interaction (Ppi)  
Down-regulating Nrf2 by tangeretin reverses multiple drug resistance to both chemotherapy and EGFR tyrosine kinase inhibitors in lung cancer Journal article
Xie Ying, Feng SenLing, He Fang, Yan PeiYu, Yao XiaoJun, Fan XingXing, Leung Elaine Lai Han, Zhou Hua. Down-regulating Nrf2 by tangeretin reverses multiple drug resistance to both chemotherapy and EGFR tyrosine kinase inhibitors in lung cancer[J]. PHARMACOLOGICAL RESEARCH, 2022, 186, 106514.
Authors:  Xie Ying;  Feng SenLing;  He Fang;  Yan PeiYu;  Yao XiaoJun; et al.
Favorite | TC[WOS]:15 TC[Scopus]:14  IF:9.1/9.0 | Submit date：2023/01/30
Drug Resistance  Chemotherapy  Egfr Tyrosine Kinase Inhibitors  Nrf2  Tangeretin