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Recent advances in bioaffinity strategies for preclinical and clinical drug discovery: Screening natural products, small molecules and antibodies Journal article
Jin, Haochun, Cui, Dianxin, Fan, Yu, Li, Guodong, Zhong, Zhangfeng, Wang, Yitao. Recent advances in bioaffinity strategies for preclinical and clinical drug discovery: Screening natural products, small molecules and antibodies[J]. Drug Discovery Today, 2024, 29(3), 103885.
Authors:  Jin, Haochun;  Cui, Dianxin;  Fan, Yu;  Li, Guodong;  Zhong, Zhangfeng; et al.
Favorite | TC[WOS]:4 TC[Scopus]:6  IF:6.5/7.3 | Submit date：2024/04/02
Antibodies  Bioaffinity Strategy  Drug Discovery  Natural Products  Small Molecule  
Small molecule inhibitors of RORγt for Th17 regulation in inflammatory and autoimmune diseases Journal article
Zeng, Jiuping, Li, Mingxing, Zhao, Qianyun, Chen, Meijuan, Zhao, Long, Wei, Shulin, Yang, Huan, Zhao, Yueshui, Wang, Anqi, Shen, Jing, Du, Fukuan, Chen, Yu, Deng, Shuai, Wang, Fang, Zhang, Zhuo, Li, Zhi, Wang, Tiangang, Wang, Shengpeng, Xiao, Zhangang, Wu, Xu. Small molecule inhibitors of RORγt for Th17 regulation in inflammatory and autoimmune diseases[J]. Journal of Pharmaceutical Analysis, 2023, 13(6), 545-562.
Authors:  Zeng, Jiuping;  Li, Mingxing;  Zhao, Qianyun;  Chen, Meijuan;  Zhao, Long; et al.
Favorite | TC[WOS]:13 TC[Scopus]:14  IF:6.1/6.8 | Submit date：2024/01/02
Autoimmune disease  Inflammatory disease  RORγt  Small-molecule inhibitor  T helper 17  
Small molecule inhibitors of RORγt for Th17 regulation in inflammatory and autoimmune diseases Review article
2023
Authors:  Zeng,Jiuping;  Li,Mingxing;  Zhao,Qianyun;  Chen,Meijuan;  Zhao,Long; et al.
Favorite | TC[WOS]:13 TC[Scopus]:14  IF:6.1/6.8 | Submit date：2023/08/03
Autoimmune Disease  Inflammatory Disease  Rorγt  Small-molecule Inhibitor  t Helper 17  
GcForest-based compound-protein interaction prediction model and its application in discovering small-molecule drugs targeting CD47 Journal article
Shan, Wenying, Chen, Lvqi, Xu, Hao, Zhong, Qinghao, Xu, Yinqiu, Yao, Hequan, Lin, Kejiang, Li, Xuanyi. GcForest-based compound-protein interaction prediction model and its application in discovering small-molecule drugs targeting CD47[J]. Frontiers in Chemistry, 2023, 11.
Authors:  Shan, Wenying;  Chen, Lvqi;  Xu, Hao;  Zhong, Qinghao;  Xu, Yinqiu; et al.
Favorite | TC[WOS]:3 TC[Scopus]:2  IF:3.8/4.8 | Submit date：2024/02/22
Artificial Intelligence  Compound-protein Interaction Prediction  Gcforest  Small-molecule Cd47 Inhibitors  Word2vec  
A novel combination treatment of antiADAM17 antibody and erlotinib to overcome acquired drug resistance in non-small cell lung cancer through the FOXO3a/FOXM1 axis Journal article
Li, Junnan, Chen, Pengchen, Wu, Qiushuang, Guo, Libin, Leong, Ka Weng, Chan, Kin Iong, Kwok, Hang Fai. A novel combination treatment of antiADAM17 antibody and erlotinib to overcome acquired drug resistance in non-small cell lung cancer through the FOXO3a/FOXM1 axis[J]. Cellular and Molecular Life Sciences, 2022, 79(12), 614.
Authors:  Li, Junnan;  Chen, Pengchen;  Wu, Qiushuang;  Guo, Libin;  Leong, Ka Weng; et al.
Favorite | TC[WOS]:7 TC[Scopus]:6  IF:6.2/7.7 | Submit date：2023/01/30
Antibody Therapy  Cell Death  Drug Target  Precision Oncology  Small Molecule  
Chaperone-Mediated Autophagy in Neurodegenerative Diseases: Molecular Mechanisms and Pharmacological Opportunities Journal article
Wang, Yi Ting, Lu, Jia Hong. Chaperone-Mediated Autophagy in Neurodegenerative Diseases: Molecular Mechanisms and Pharmacological Opportunities[J]. Cells, 2022, 11(14), 2250.
Authors:  Wang, Yi Ting;  Lu, Jia Hong
Favorite | TC[WOS]:25 TC[Scopus]:24  IF:5.1/6.0 | Submit date：2022/08/24
Alzheimer’s Disease  Autophagy  Chaperone-mediated Autophagy  Hsc70  Huntington’s Disease  Lamp2a  Neurodegenerative Disease  Parkinson’s Disease  Small Molecule  Α-synuclein  
Small molecules targeting ubiquitination to control inflammatory diseases Journal article
Zheng-Qing Li, Xiuping Chen, Ying Wang. Small molecules targeting ubiquitination to control inflammatory diseases[J]. DRUG DISCOVERY TODAY, 2021, 26(10), 2414-2422.
Authors:  Zheng-Qing Li;  Xiuping Chen;  Ying Wang
Favorite | TC[WOS]:5 TC[Scopus]:4  IF:6.5/7.3 | Submit date：2021/12/08
Ubiquitin  Ubiquitination System  Inflammatory Diseases  Small Molecule Modulator  
Targeting the NLRP3 inflammasome as new therapeutic avenue for inflammatory bowel disease Journal article
Chen, Qiu Ling, Yin, Hao Ran, He, Qing Yu, Wang, Ying. Targeting the NLRP3 inflammasome as new therapeutic avenue for inflammatory bowel disease[J]. Biomedicine and Pharmacotherapy, 2021, 138, 111442.
Authors:  Chen, Qiu Ling;  Yin, Hao Ran;  He, Qing Yu;  Wang, Ying
Favorite | TC[WOS]:67 TC[Scopus]:70  IF:6.9/6.8 | Submit date：2021/12/08
Inflammatory Bowel Disease  Nlrp3  Small Molecule Inhibitor  Targeted Therapy  
Food bioactive small molecule databases: Deep boosting for the study of food molecular behaviors Journal article
Yang,Zheng Fei, Xiao,Ran, Luo,Fei Jun, Lin,Qin Lu, Ouyang,Defang, Dong,Jie, Zeng,Wen Bin. Food bioactive small molecule databases: Deep boosting for the study of food molecular behaviors[J]. Innovative Food Science and Emerging Technologies, 2020, 66, 102499.
Authors:  Yang,Zheng Fei;  Xiao,Ran;  Luo,Fei Jun;  Lin,Qin Lu;  Ouyang,Defang; et al.
Favorite | TC[WOS]:4 TC[Scopus]:5  IF:6.3/6.5 | Submit date：2021/03/02
Bioactive Data  Food  Food Compound  Food Database  Small Molecule  
Identification of Novel Pyruvate Dehydrogenase Kinase 1 (PDK1) Inhibitors by Kinase Activity-Based High-Throughput Screening for Anticancer Therapeutics Journal article
Zhang W., Hu X., Chakravarty H., Yang Z., Tam K.Y.. Identification of Novel Pyruvate Dehydrogenase Kinase 1 (PDK1) Inhibitors by Kinase Activity-Based High-Throughput Screening for Anticancer Therapeutics[J]. ACS Combinatorial Science, 2018, 20(11), 660-671.
Authors:  Zhang W.;  Hu X.;  Chakravarty H.;  Yang Z.;  Tam K.Y.
Favorite | TC[WOS]:12 TC[Scopus]:12 | Submit date：2018/12/18
Cancer  High-throughput Screening  Pyruvate Dehydrogenase Kinase 1  Small Molecule Inhibitors  Warburg Effect