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A NIR iridium(III) complex-based luminescence probe for imaging mitochondria pyruvate dehydrogenase kinase 1 in triple-negative breast cancer cells Journal article
Jing, Shaozhen, Song, Ying Qi, Liu, Jingqi, Zhao, Chen, Wang, Ling, Chan, Daniel Shiu Hin, Wong, Chun Yuen, Lee, Simon Ming Yuen, Wang, Jing, Leung, Chung Hang, Wang, Wanhe. A NIR iridium(III) complex-based luminescence probe for imaging mitochondria pyruvate dehydrogenase kinase 1 in triple-negative breast cancer cells[J]. Sensors and Actuators B: Chemical, 2024, 418, 136265.
Authors:  Jing, Shaozhen;  Song, Ying Qi;  Liu, Jingqi;  Zhao, Chen;  Wang, Ling; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:8.0/7.0 | Submit date：2024/08/05
Breast Cancer  Dichloroacetic Acid (Dca)  Iridium(Iii) Complex  Mitochondrial Targeting  Nir Imaging  Pyruvate Dehydrogenase Kinase 1 (Pdk1)  
Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships Journal article
Zhang,Shao Lin, Yang,Zheng, Hu,Xiaohui, Tam,Kin Yip. Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships[J]. Bioorganic and Medicinal Chemistry Letters, 2018, 28(21), 3441-3445.
Authors:  Zhang,Shao Lin;  Yang,Zheng;  Hu,Xiaohui;  Tam,Kin Yip
Favorite | TC[WOS]:16 TC[Scopus]:16  IF:2.5/2.4 | Submit date：2021/03/04
Antiproliferative Activity  Dichloroacetophenone  Kinase Inhibition  Pyruvate Dehydrogenase Complex  Pyruvate Dehydrogenase Kinase  
Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships Journal article
Zhang, Shao-Lin, Yang, Zheng, Hu, Xiaohui, Tam, Kin Yip. Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 28(21), 3441-3445.
Authors:  Zhang, Shao-Lin;  Yang, Zheng;  Hu, Xiaohui;  Tam, Kin Yip
Favorite | TC[WOS]:16 TC[Scopus]:16  IF:2.5/2.4 | Submit date：2018/10/30
Pyruvate Dehydrogenase Kinase  Pyruvate Dehydrogenase Complex  Antiproliferative Activity  Dichloroacetophenone  Kinase Inhibition  
Anticancer effects of some novel dichloroacetophenones through the inhibition of pyruvate dehydrogenase kinase 1 Journal article
Zhang, Shao-Lin, Yang, Zheng, Hu, Xiaohui, Chakravarty, Harapriya, Tam, Kin Yip. Anticancer effects of some novel dichloroacetophenones through the inhibition of pyruvate dehydrogenase kinase 1[J]. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2018, 123, 43-55.
Authors:  Zhang, Shao-Lin;  Yang, Zheng;  Hu, Xiaohui;  Chakravarty, Harapriya;  Tam, Kin Yip
Favorite | TC[WOS]:15 TC[Scopus]:15  IF:4.3/4.2 | Submit date：2018/10/30
Dichloroacetophenone  Pyruvate Dehydrogenase Kinase  Pyruvate Dehydrogenase Complex  Anticancer Activity  Metabolic Reprogramming  
Synthesis and biological evaluation of (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides as pyruvate dehydrogenase kinase 1 (PDK1) inhibitors to reduce the growth of cancer cells Journal article
Zhang S.-L., Zhang W., Yang Z., Hu X., Tam K.Y.. Synthesis and biological evaluation of (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides as pyruvate dehydrogenase kinase 1 (PDK1) inhibitors to reduce the growth of cancer cells[J]. European Journal of Pharmaceutical Sciences, 2017, 110, 87-92.
Authors:  Zhang S.-L.;  Zhang W.;  Yang Z.;  Hu X.;  Tam K.Y.
Favorite | TC[WOS]:7 TC[Scopus]:7 | Submit date：2018/12/18
Anti-proliferation  Binding Affinity  Pyruvate Dehydrogenase Complex  Pyruvate Dehydrogenase Kinase  
Synthesis and biological evaluation of (R)-3,3,3-trifluoro-2-hydroxy-2methylpropionamides as pyruvate dehydrogenase kinase 1 (PDK1) inhibitors to reduce the growth of cancer cells Conference paper
Zhang, Shao-Lin, Zhang, Wen, Yang, Zheng, Hu, Xiaohui, Tam, Kin Yip. Synthesis and biological evaluation of (R)-3,3,3-trifluoro-2-hydroxy-2methylpropionamides as pyruvate dehydrogenase kinase 1 (PDK1) inhibitors to reduce the growth of cancer cells[C], PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS:ELSEVIER SCIENCE BV, 2017, 87-92.
Authors:  Zhang, Shao-Lin;  Zhang, Wen;  Yang, Zheng;  Hu, Xiaohui;  Tam, Kin Yip
Favorite | TC[WOS]:7 TC[Scopus]:7 | Submit date：2018/10/30
Pyruvate Dehydrogenase Kinase  Pyruvate Dehydrogenase Complex  Anti-proliferation  Binding Affinity  
Synthesis and biological evaluation of (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides as pyruvate dehydrogenase kinase 1 (PDK1) inhibitors to reduce the growth of cancer cells Journal article
Zhang,Shao Lin, Zhang,Wen, Yang,Zheng, Hu,Xiaohui, Tam,Kin Yip. Synthesis and biological evaluation of (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides as pyruvate dehydrogenase kinase 1 (PDK1) inhibitors to reduce the growth of cancer cells[J]. European Journal of Pharmaceutical Sciences, 2017, 110, 87-92.
Authors:  Zhang,Shao Lin;  Zhang,Wen;  Yang,Zheng;  Hu,Xiaohui;  Tam,Kin Yip
Favorite | TC[WOS]:7 TC[Scopus]:7  IF:4.3/4.2 | Submit date：2021/03/04
Anti-proliferation  Binding Affinity  Pyruvate Dehydrogenase Complex  Pyruvate Dehydrogenase Kinase  
Synthesis and biological evaluation of (R)-3,3,3-trifluoro-2-hydroxy-2- methylpropionamides as pyruvate dehydrogenase kinase 1 (PDK1) inhibitors to reduce the growth of cancer cells Journal article
Zhang, S.L., Zhang, W., Yang, Z., Hu, X., Tam, K. Y.. Synthesis and biological evaluation of (R)-3,3,3-trifluoro-2-hydroxy-2- methylpropionamides as pyruvate dehydrogenase kinase 1 (PDK1) inhibitors to reduce the growth of cancer cells[J]. European Journal of Pharmaceutical Sciences, 2017, 87-92.
Authors:  Zhang, S.L.;  Zhang, W.;  Yang, Z.;  Hu, X.;  Tam, K. Y.
Favorite | TC[WOS]:7 TC[Scopus]:7  IF:4.3/4.2 | Submit date：2022/07/28
Pyruvate Dehydrogenase Kinase  Pyruvate Dehydrogenase Complex  Anti-proliferation  Binding Affinity  
Unexpected Discovery of Dichloroacetate Derived AdenosineTriphosphate Competitors Targeting Pyruvate DehydrogenaseKinase To Inhibit Cancer Proliferation Journal article
Zhang, S.L., Hu, X., Zhang, W., Tam, K. Y.. Unexpected Discovery of Dichloroacetate Derived AdenosineTriphosphate Competitors Targeting Pyruvate DehydrogenaseKinase To Inhibit Cancer Proliferation[J]. Jourma of Medicinal Chemistry, 2016, 3562-3568.
Authors:  Zhang, S.L.;  Hu, X.;  Zhang, W.;  Tam, K. Y.
Favorite | TC[WOS]:44 TC[Scopus]:46  IF:6.8/7.1 | Submit date：2022/07/28
Pyruvate Dehydrogenase Kinase  Pyruvate Dehydrogenase Complex  Atp Binding Pocket  Pyruvate Binding Pocket  Dichloroacetate Sodium  
Targeting tumor metabolism for cancer treatment: Is pyruvate dehydrogenase kinases (PDKs) a viable anticancer target? Journal article
Wen Zhang, Shao-Lin Zhang, Xiaohui Hu, Kin Yip Tam. Targeting tumor metabolism for cancer treatment: Is pyruvate dehydrogenase kinases (PDKs) a viable anticancer target?[J]. International Journal of Biological Sciences, 2015, 11(12), 1390-1400.
Authors:  Wen Zhang;  Shao-Lin Zhang;  Xiaohui Hu;  Kin Yip Tam
Favorite | TC[WOS]:118 TC[Scopus]:125  IF:8.2/8.3 | Submit date：2019/01/07
Aerobic Glycolysis  Pyruvate Dehydrogenase Kinases  Tumor Metabolism  Pyruvate Dehydrogenase Complex