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BET inhibition induces synthetic lethality in PTEN deficient colorectal cancers via dual action on p21CIP1/WAF1 Journal article
Ren, Guowen, Chen, Jinghong, Pu, Yue, Yang, Eun Ju, Tao, Shishi, Mou, Pui Kei, Chen, Li Jie, Zhu, Wenli, Chan, Kin Long, Luo, Guanghui, Deng, Chuxia, Shim, Joong Sup. BET inhibition induces synthetic lethality in PTEN deficient colorectal cancers via dual action on p21CIP1/WAF1[J]. International Journal of Biological Sciences, 2024, 20(6), 1978-1991.
Authors:  Ren, Guowen;  Chen, Jinghong;  Pu, Yue;  Yang, Eun Ju;  Tao, Shishi; et al.
Favorite | TC[WOS]:1 TC[Scopus]:1  IF:8.2/8.3 | Submit date：2024/05/16
Akt  Bet  Colorectal Cancer  Myc  P21  PhosphorylAted P21 At Thr145  Pten  Synthetic Lethality  
Classification of PTEN missense VUS through exascale simulations Journal article
Sinha, Siddharth, Li, Jiaheng, Tam, Benjamin, Wang, San Ming. Classification of PTEN missense VUS through exascale simulations[J]. Briefings in Bioinformatics, 2023, 24(6), bbad361.
Authors:  Sinha, Siddharth;  Li, Jiaheng;  Tam, Benjamin;  Wang, San Ming
Favorite | TC[WOS]:1 TC[Scopus]:1  IF:6.8/7.9 | Submit date：2023/12/04
Evolution Selection  Lipid Phosphatase Activity  Md Simulations  Pten  Replica Exchange Molecular Dynamics (Remd) Simulations  Variants Of Uncertain Significance (Vus)  
The Long and the Short of PTEN in the Regulation of Mitophagy Review article
2020
Authors:  Wang,Liming;  Lu,Guang;  Shen,Han Ming
Favorite | TC[WOS]:24 TC[Scopus]:25  IF:4.6/5.2 | Submit date：2021/03/02
Mitophagy  Pink1  Parkin  Bnip3  Pten  Pten-l  
Exosomes derived from normal human bronchial epithelial cells down-regulate proliferation and migration of hydroquinone-transformed malignant recipient cells via up-regulating PTEN expression Journal article
Lian,Zhenwei, Hu,Zuqing, Xian,Hongyi, Jiang,Ran, Huang,Haoyu, Jiang,Yunxia, Zheng,Zhongdaixi, Lloyd,R. Stephen, Yuan,Jianhui, Sha,Yan, Wang,Sanming, Hu,Dalin. Exosomes derived from normal human bronchial epithelial cells down-regulate proliferation and migration of hydroquinone-transformed malignant recipient cells via up-regulating PTEN expression[J]. Chemosphere, 2020, 244(125496).
Authors:  Lian,Zhenwei;  Hu,Zuqing;  Xian,Hongyi;  Jiang,Ran;  Huang,Haoyu; et al.
Favorite | TC[WOS]:11 TC[Scopus]:10  IF:8.1/7.7 | Submit date：2021/03/02
Benzene  Toxicity  Exosomes  Pten  Proliferation  Migration  
Histone acetyltransferase (HAT) P300/CBP inhibitors induce synthetic lethality in pten-deficient colorectal cancer cells through destabilizing AKT Journal article
Liu,Yifan, Yang,Eun Ju, Shi,Changxiang, Mou,Pui Kei, Zhang,Baoyuan, Wu,Changjie, Lyu,Junfang, Shim,Joong Sup. Histone acetyltransferase (HAT) P300/CBP inhibitors induce synthetic lethality in pten-deficient colorectal cancer cells through destabilizing AKT[J]. International Journal of Biological Sciences, 2020, 16(11), 1774-1784.
Authors:  Liu,Yifan;  Yang,Eun Ju;  Shi,Changxiang;  Mou,Pui Kei;  Zhang,Baoyuan; et al.
Favorite | TC[WOS]:15 TC[Scopus]:15  IF:8.2/8.3 | Submit date：2021/03/04
Akt  Anacardic Acid  Histone Acetyltransferases  Hsp70  Pten  Synthetic Lethality  
Synthetic lethality screening identifies a potential role of Hsp90 in drug resistance of PTEN-deficient colorectal cancer Conference paper
Liu, Y., Yang, E.J., Zhang, B., Miao, Z., Wu, C., Lyu, J., Tan, K., Wong, K. H., Poon, C. W., Joong, S. S.. Synthetic lethality screening identifies a potential role of Hsp90 in drug resistance of PTEN-deficient colorectal cancer[C], 2017.
Authors:  Liu, Y.;  Yang, E.J.;  Zhang, B.;  Miao, Z.;  Wu, C.; et al.
Favorite |  | Submit date：2022/07/27
PTEN  tumor supressor  
Folic acid consumption reduces resistin level and restores blunted acetylcholine-induced aortic relaxation in obese/diabetic mice Journal article
Sai Wang Seto, Tsz Yan Lam, Penelope Mei Yu Or, Wayne Yuk Wai Lee, Alice Lai Shan Au, Christina Chui Wa Poon, Rachel Wai Sum Li, Shun Wan Chan, John Hok Keung Yeung, George Pak Heng Leung, Simon Ming Yuen Lee, Sai Ming Ngai, Yiu Wa Kwan. Folic acid consumption reduces resistin level and restores blunted acetylcholine-induced aortic relaxation in obese/diabetic mice[J]. Journal of Nutritional Biochemistry, 2010, 21(9), 872-880.
Authors:  Sai Wang Seto;  Tsz Yan Lam;  Penelope Mei Yu Or;  Wayne Yuk Wai Lee;  Alice Lai Shan Au; et al.
Favorite | TC[WOS]:20 TC[Scopus]:24 | Submit date：2018/11/06
+db/+db Mice  Acetylcholine  Enos  Folic Acid  Pten  Relaxation  
PTEN deletion leads to deregulation of antioxidants and increased oxidative damage in mouse embryonic fibroblasts Journal article
Yan-Ying Huo, Gang Li, Rui-Feng Duan, Qiao Gou, Chun-Ling Fu, Ying-Chun Hu, Bo-Qiang Song, Zhi-Hua Yang, De-Chang Wu, Ping-Kun Zhou. PTEN deletion leads to deregulation of antioxidants and increased oxidative damage in mouse embryonic fibroblasts[J]. FREE RADICAL BIOLOGY AND MEDICINE, 2008, 44(8), 1578-1591.
Authors:  Yan-Ying Huo;  Gang Li;  Rui-Feng Duan;  Qiao Gou;  Chun-Ling Fu; et al.
Favorite | TC[WOS]:34 TC[Scopus]:40  IF:7.1/7.9 | Submit date：2019/01/22
Pten  Reactive Oxygen Species  Peroxiredoxin  Cu  Zn Superoxide Dismutase  Oxidative Damage  Free Radicals  
Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland Journal article
Gang Li, Gertraud W. Robinson, Ralf Lesche, Hilda Martinez-Diaz, Zhaorong Jiang, Nora Rozengurt, Kay-Uwe Wagner, De-Chang Wu, Timothy F. Lane, Xin Liu, Lothar Hennighausen, Hong Wu. Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland[J]. DEVELOPMENT, 2002, 129(17), 4159-4170.
Authors:  Gang Li;  Gertraud W. Robinson;  Ralf Lesche;  Hilda Martinez-Diaz;  Zhaorong Jiang; et al.
Favorite | TC[WOS]:215 TC[Scopus]:233  IF:3.7/5.0 | Submit date：2019/01/22
Pten  Mammary Development  Cowden’s Disease  Ductal Growth  Apoptosis