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Multiple initiatives to conquer KRAS G12C inhibitor resistance from the perspective of clinical therapy Journal article
Zhang JunMin, Zhang JuanHong, Leung Elaine Lai Han, Yao XiaoJun. Multiple initiatives to conquer KRAS G12C inhibitor resistance from the perspective of clinical therapy[J]. EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2023, 32(2), 101-106.
Authors:  Zhang JunMin;  Zhang JuanHong;  Leung Elaine Lai Han;  Yao XiaoJun
Favorite | TC[WOS]:2 TC[Scopus]:2  IF:4.9/5.3 | Submit date：2023/06/15
Kras G12c  Amg 510  Mrtx 849  Targeted Therapy  Drug Resistance  
Regulation of IFN-γ-mediated PD-L1 expression by MYC in colorectal cancer with wild-type KRAS and TP53 and its clinical implications Journal article
Guo, Libin, Tang, Xiaoqiong, Wong, Sin Wa, Guo, Anyuan, Lin, Yao, Kwok, Hang Fai. Regulation of IFN-γ-mediated PD-L1 expression by MYC in colorectal cancer with wild-type KRAS and TP53 and its clinical implications[J]. Frontiers in Pharmacology, 2022, 13, 1022129.
Authors:  Guo, Libin;  Tang, Xiaoqiong;  Wong, Sin Wa;  Guo, Anyuan;  Lin, Yao; et al.
Favorite | TC[WOS]:3 TC[Scopus]:3  IF:4.4/5.0 | Submit date：2023/01/30
Anti-pd-1  Ifn-γ  Kras  Myc  Pd-l1 Expression  Tp53  Ifn-gamma  
In Silico Study of the Acquired Resistance Caused by the Secondary Mutations of KRAS G12C Protein Using Long Time Molecular Dynamics Simulation and Markov State Model Analysis Journal article
Tu Gao, Liu Qing, Qiu Yue, Leung Elaine Lai Han, Yao XiaoJun. In Silico Study of the Acquired Resistance Caused by the Secondary Mutations of KRAS G12C Protein Using Long Time Molecular Dynamics Simulation and Markov State Model Analysis[J]. International Journal of Molecular Sciences, 2022, 23(22), 13845.
Authors:  Tu Gao;  Liu Qing;  Qiu Yue;  Leung Elaine Lai Han;  Yao XiaoJun
Favorite | TC[WOS]:6 TC[Scopus]:8 | Submit date：2023/01/31
Kras G12c Inhibitor  Drug Resistance  Molecular Dynamics  Markov State Model  
Mechanistic insights into the clinical Y96D mutation with acquired resistance to AMG510 in the KRASG12C Journal article
Zhuang, Haiming, Fan, Jigang, Li, Mingyu, Zhang, Hao, Yang, Xiuyan, Lin, Ligen, Lu, Shaoyong, Wang, Qing, Liu, Yaqin. Mechanistic insights into the clinical Y96D mutation with acquired resistance to AMG510 in the KRASG12C[J]. Frontiers in Oncology, 2022, 12, 915512.
Authors:  Zhuang, Haiming;  Fan, Jigang;  Li, Mingyu;  Zhang, Hao;  Yang, Xiuyan; et al.
Favorite | TC[WOS]:7 TC[Scopus]:6  IF:3.5/4.0 | Submit date：2022/09/07
Amg510  Drug Resistance  G12c  Kras  Molecular Dynamics Simulations  
Post-translational modification of KRAS: potential targets for cancer therapy Journal article
Wang,Wei hua, Yuan,Tao, Qian,Mei jia, Yan,Fang jie, Yang,Liu, He,Qiao jun, Yang,Bo, Lu,Jin jian, Zhu,Hong. Post-translational modification of KRAS: potential targets for cancer therapy[J]. Acta Pharmacologica Sinica, 2020, 42(8), 1201-1211.
Authors:  Wang,Wei hua;  Yuan,Tao;  Qian,Mei jia;  Yan,Fang jie;  Yang,Liu; et al.
Favorite | TC[WOS]:29 TC[Scopus]:27  IF:6.9/7.6 | Submit date：2021/03/02
Acetylation  Cancer Therapy  Kras  Nitrosylation  Oncogene  Palmitoylation  Phosphorylation  Post-translational Modification  Postprenylation  Prenylation  Sumoylation  Ubiquitination  
Rapid discrimination of colon cancer cells with single base mutation in KRAS gene segment using laser tweezers Raman spectroscopy Journal article
Mengmeng Liu, Xiujie Liu, Zufang Huang, Xiaoqiong Tang, Xueliang Lin, Yunchao Xu, Guannan Chen, Hang Fai Kwok, Yao Lin, Shangyuan Feng. Rapid discrimination of colon cancer cells with single base mutation in KRAS gene segment using laser tweezers Raman spectroscopy[J]. JOURNAL OF BIOPHOTONICS, 2019, 12(3).
Authors:  Mengmeng Liu;  Xiujie Liu;  Zufang Huang;  Xiaoqiong Tang;  Xueliang Lin; et al.
Favorite | TC[WOS]:9 TC[Scopus]:11  IF:2.0/2.6 | Submit date：2020/05/20
Cancer Cell Screening  Kras Mutant  Optical Tweezers  Raman Spectroscopy  Single Base Mutation  
Rapid discrimination of colon cancer cells with single base mutation in KRAS gene segment using laser tweezers Raman spectroscopy Journal article
Liu, M., Liu, X., Huang, Z., Tang, X., Lin, X., Xu, Y., Kwok, H. F., Lin, Y., Feng, S.. Rapid discrimination of colon cancer cells with single base mutation in KRAS gene segment using laser tweezers Raman spectroscopy[J]. Journal of Biophotonics, 2018, -----.
Authors:  Liu, M.;  Liu, X.;  Huang, Z.;  Tang, X.;  Lin, X.; et al.
Favorite |  | Submit date：2022/06/02
Raman optical tweezers  KRAS mutant  Cancer cell screening