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Introducing enzymatic cleavage features and transfer learning realizes accurate peptide half-life prediction across species and organs Journal article
Tan, Xiaorong, Liu, Qianhui, Fang, Yanpeng, Yang, Sen, Chen, Fei, Wang, Jianmin, Ouyang, Defang, Dong, Jie, Zeng, Wenbin. Introducing enzymatic cleavage features and transfer learning realizes accurate peptide half-life prediction across species and organs[J]. Briefings in Bioinformatics, 2024, 25(4), bbae350.
Authors:  Tan, Xiaorong;  Liu, Qianhui;  Fang, Yanpeng;  Yang, Sen;  Chen, Fei; et al.
Favorite | TC[WOS]:1 TC[Scopus]:1  IF:6.8/7.9 | Submit date：2024/08/05
Drug Design  Enzymatic Cleavage Features  Half-life  Machine Learning  Peptide Drugs  Transfer Learning  
Dual-target inhibitors of cholinesterase and GSK-3beta to modulate Alzheimer's disease Journal article
He Junqiu, TAM KIN YIP. Dual-target inhibitors of cholinesterase and GSK-3beta to modulate Alzheimer's disease[J]. Drug Discovery Today, 2024, 29(4), 1-8.
Authors:  He Junqiu;  TAM KIN YIP
Adobe PDF | Favorite | TC[WOS]:2 TC[Scopus]:3  IF:6.5/7.3 | Submit date：2024/08/29
Gsk-3b  Cholinesterase  Dual-target Inhibitors  Alzheimer’s Disease  Drug Design Strategy  
Dual-target inhibitors of cholinesterase and GSK-3β to modulate Alzheimer's disease Other
2024-04-01
Authors:  He, Junqiu;  Tam, Kin Yip
Favorite | TC[WOS]:2 TC[Scopus]:3 | Submit date：2024/05/02
Alzheimer's Disease  Cholinesterase  Drug Design Strategy  Dual-target Inhibitors  Gsk-3β  
FormulationAI: a novel web-based platform for drug formulation design driven by artificial intelligence Journal article
Dong, Jie, Wu, Zheng, Xu, Huanle, Ouyang, Defang. FormulationAI: a novel web-based platform for drug formulation design driven by artificial intelligence[J]. Briefings in Bioinformatics, 2024, 25(1), bbad419.
Authors:  Dong, Jie;  Wu, Zheng;  Xu, Huanle;  Ouyang, Defang
Favorite | TC[WOS]:5 TC[Scopus]:11  IF:6.8/7.9 | Submit date：2024/02/22
Artificial Intelligence  Computational Pharmaceutics  Drug Design  Drug Formulation  Formulationai  Webserver  
The development of small-molecule inhibitors targeting hexokinase 2 Journal article
Shen Wenying, Zhou Yan, TAM KIN YIP. The development of small-molecule inhibitors targeting hexokinase 2[J]. Drug Discovery Today, 2022, 27(9), 2574-2585.
Authors:  Shen Wenying;  Zhou Yan;  TAM KIN YIP
Adobe PDF | Favorite | TC[WOS]:22 TC[Scopus]:20  IF:6.5/7.3 | Submit date：2024/08/29
Cancer Metabolism  Hexokinase 2  Drug–target Binding  Selective Inhibition  Structure-based Molecular Design  
Design, synthesis and antitumor evaluation of novel 1H-indole-2-carboxylic acid derivatives targeting 14-3-3η protein Journal article
Gao, Zhenxiong, Fan, Tingting, Chen, Linbo, Yang, Mengchu, Wai Wong, Vincent Kam, Chen, Dawei, Liu, Zijian, Zhou, Yaoyao, Wu, Weibin, Qiu, Zixuan, Zhang, Cunlong, Li, Yuan, Jiang, Yuyang. Design, synthesis and antitumor evaluation of novel 1H-indole-2-carboxylic acid derivatives targeting 14-3-3η protein[J]. European Journal of Medicinal Chemistry, 2022, 238.
Authors:  Gao, Zhenxiong;  Fan, Tingting;  Chen, Linbo;  Yang, Mengchu;  Wai Wong, Vincent Kam; et al.
Favorite | TC[WOS]:3 TC[Scopus]:3  IF:6.0/6.1 | Submit date：2023/01/30
14-3-3η Protein  Antitumor Bioactivity  Drug Design  Hepatocellular Carcinoma  Novel Target  
Editorial: Insights in Protein Chemistry and Enzymology: 2021 Other
2022-06-20
Authors:  Kwok, Hang Fai;  Zhang, Qi
Favorite | TC[WOS]:0 TC[Scopus]:0 | Submit date：2022/08/01
Drug Discovery  Enzymology Characterization  Inhibitor  Protein Chemistry Design And Folding  Proteomic Analyses  Structural Biology  
The development of small-molecule inhibitors targeting hexokinase 2 Review article
2022
Authors:  Shan, Wenying;  Zhou, Yan;  Tam, Kin Yip
Favorite | TC[WOS]:22 TC[Scopus]:20  IF:6.5/7.3 | Submit date：2022/08/05
Cancer Metabolism  Hexokinase 2  Drug–target Binding  Selective Inhibition  Structure-based Molecular Design  
Proteases—From Basic Structure to Function to Drug Design as Targeted Therapy Book
Kwok, Hang Fai, Shaw, Chris, Walker, Brian. Proteases—From Basic Structure to Function to Drug Design as Targeted Therapy[M]. Switzerland:MDPI, 2021.
Authors:  Kwok, Hang Fai;  Shaw, Chris;  Walker, Brian
Favorite | TC[WOS]:1 TC[Scopus]:1 | Submit date：2022/06/02
Protease Inhibitor  Targeted Therapy  Drug Design And Development  Oncology  Precision Medicine  
PharmDE: A new expert system for drug-excipient compatibility evaluation Journal article
Wang, Nannan, Sun, Huimin, Dong, Jie, Ouyang, Defang. PharmDE: A new expert system for drug-excipient compatibility evaluation[J]. International Journal of Pharmaceutics, 2021, 607, 120962.
Authors:  Wang, Nannan;  Sun, Huimin;  Dong, Jie;  Ouyang, Defang
Favorite | TC[WOS]:20 TC[Scopus]:26  IF:5.3/5.6 | Submit date：2021/12/08
Drug-excipient Compatibility  Formulation Design  Expert System  Database  Prediction  Artificial Intelligence