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α-mangostin derivative 4e as a PDE4 inhibitor promote proteasomal degradation of alpha-synuclein in Parkinson's disease models through PKA activation
Journal article
Chen, Jia Yue, Zhu, Qi, Cai, Cui Zan, Luo, Hai Bin, Lu, Jia Hong. α-mangostin derivative 4e as a PDE4 inhibitor promote proteasomal degradation of alpha-synuclein in Parkinson's disease models through PKA activation[J]. Phytomedicine, 2022, 101, 154125.
Authors:
Chen, Jia Yue
;
Zhu, Qi
;
Cai, Cui Zan
;
Luo, Hai Bin
;
Lu, Jia Hong
Favorite
|
TC[WOS]:
8
TC[Scopus]:
8
IF:
6.7
/
6.2
|
Submit date:2022/05/31
Alpha-synuclein (Α-syn)
Parkinson's Disease
Phosphodiesterase 4 Inhibitor
Protein Kinase a (Pka)
Ubiquitin-proteasome System (Ups)
Natural alkaloid harmine promotes degradation of alpha-synuclein via PKA-mediated ubiquitin-proteasome system activation
Journal article
Cai,Cui Zan, Zhou,He Feng, Yuan,Ning Ning, Wu,Ming Yue, Lee,Simon Ming Yuen, Ren,Jiao Yan, Su,Huan Xing, Lu,Jin Jian, Chen,Xiu Ping, Li,Min, Tan,Jie Qiong, Lu,Jia Hong. Natural alkaloid harmine promotes degradation of alpha-synuclein via PKA-mediated ubiquitin-proteasome system activation[J]. Phytomedicine, 2019, 61.
Authors:
Cai,Cui Zan
;
Zhou,He Feng
;
Yuan,Ning Ning
;
Wu,Ming Yue
;
Lee,Simon Ming Yuen
; et al.
Favorite
|
TC[WOS]:
33
TC[Scopus]:
38
IF:
6.7
/
6.2
|
Submit date:2021/03/01
-synuclein
Harmine
Parkinson's Disease
Protein Kinase a
Ubiquitin-proteasome System
Canthin-6-One Accelerates Alpha-Synuclein Degradation by Enhancing UPS Activity: Drug Target Identification by CRISPR-Cas9 Whole Genome-Wide Screening Technology
Journal article
Ning-Ning Yuan, Cui-Zan Cai, Ming-Yue Wu, Qi Zhu, HuanXing Su, Min Li, JiaoYan Ren, Jie-Qiong Tan, Jia-Hong Lu. Canthin-6-One Accelerates Alpha-Synuclein Degradation by Enhancing UPS Activity: Drug Target Identification by CRISPR-Cas9 Whole Genome-Wide Screening Technology[J]. FRONTIERS IN PHARMACOLOGY, 2019, 10.
Authors:
Ning-Ning Yuan
;
Cui-Zan Cai
;
Ming-Yue Wu
;
Qi Zhu
;
HuanXing Su
; et al.
Favorite
|
TC[WOS]:
17
TC[Scopus]:
20
IF:
4.4
/
5.0
|
Submit date:2020/04/14
Canthin-6-one
Parkinson’s Disease
Alpha-synuclein
Ubiquitin-proteasome-system
Crispr/cas9
Rpn2/psmd1
Pka
Corynoxine, a natural autophagy enhancer, promotes the clearance of alpha-synuclein via Akt/mTOR pathway
Journal article
Chen L.-L., Song J.-X., Lu J.-H., Yuan Z.-W., Liu L.-F., Durairajan S.S.K., Li M.. Corynoxine, a natural autophagy enhancer, promotes the clearance of alpha-synuclein via Akt/mTOR pathway[J]. Journal of Neuroimmune Pharmacology, 2014, 9(3), 380-387.
Authors:
Chen L.-L.
;
Song J.-X.
;
Lu J.-H.
;
Yuan Z.-W.
;
Liu L.-F.
; et al.
Favorite
|
TC[WOS]:
78
TC[Scopus]:
84
|
Submit date:2019/01/15
Alpha-synuclein
Autophagy
Corynoxine
Mtor
Parkinson's Disease
Baicalein Inhibits Formation of α-Synuclein Oligomers within Living Cells and Prevents Aβ Peptide Fibrillation and Oligomerisation
Journal article
Lu J.-H., Ardah M.T., Durairajan S.S.K., Liu L.-F., Xie L.-X., Fong W.-F.D., Hasan M.Y., Huang J.-D., El-Agnaf O.M.A., Li M.. Baicalein Inhibits Formation of α-Synuclein Oligomers within Living Cells and Prevents Aβ Peptide Fibrillation and Oligomerisation[J]. ChemBioChem, 2011, 12(4), 615-624.
Authors:
Lu J.-H.
;
Ardah M.T.
;
Durairajan S.S.K.
;
Liu L.-F.
;
Xie L.-X.
; et al.
Favorite
|
TC[WOS]:
132
TC[Scopus]:
157
|
Submit date:2019/01/15
Alpha-synuclein
Amyloid Beta-peptides
Baicalein
Neurological Agents
Oligomerization