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α-mangostin derivative 4e as a PDE4 inhibitor promote proteasomal degradation of alpha-synuclein in Parkinson's disease models through PKA activation Journal article
Chen, Jia Yue, Zhu, Qi, Cai, Cui Zan, Luo, Hai Bin, Lu, Jia Hong. α-mangostin derivative 4e as a PDE4 inhibitor promote proteasomal degradation of alpha-synuclein in Parkinson's disease models through PKA activation[J]. Phytomedicine, 2022, 101, 154125.
Authors:  Chen, Jia Yue;  Zhu, Qi;  Cai, Cui Zan;  Luo, Hai Bin;  Lu, Jia Hong
Favorite | TC[WOS]:8 TC[Scopus]:8  IF:6.7/6.2 | Submit date:2022/05/31
Alpha-synuclein (Α-syn)  Parkinson's Disease  Phosphodiesterase 4 Inhibitor  Protein Kinase a (Pka)  Ubiquitin-proteasome System (Ups)  
Natural alkaloid harmine promotes degradation of alpha-synuclein via PKA-mediated ubiquitin-proteasome system activation Journal article
Cai,Cui Zan, Zhou,He Feng, Yuan,Ning Ning, Wu,Ming Yue, Lee,Simon Ming Yuen, Ren,Jiao Yan, Su,Huan Xing, Lu,Jin Jian, Chen,Xiu Ping, Li,Min, Tan,Jie Qiong, Lu,Jia Hong. Natural alkaloid harmine promotes degradation of alpha-synuclein via PKA-mediated ubiquitin-proteasome system activation[J]. Phytomedicine, 2019, 61.
Authors:  Cai,Cui Zan;  Zhou,He Feng;  Yuan,Ning Ning;  Wu,Ming Yue;  Lee,Simon Ming Yuen; et al.
Favorite | TC[WOS]:33 TC[Scopus]:38  IF:6.7/6.2 | Submit date:2021/03/01
-synuclein  Harmine  Parkinson's Disease  Protein Kinase a  Ubiquitin-proteasome System  
Canthin-6-One Accelerates Alpha-Synuclein Degradation by Enhancing UPS Activity: Drug Target Identification by CRISPR-Cas9 Whole Genome-Wide Screening Technology Journal article
Ning-Ning Yuan, Cui-Zan Cai, Ming-Yue Wu, Qi Zhu, HuanXing Su, Min Li, JiaoYan Ren, Jie-Qiong Tan, Jia-Hong Lu. Canthin-6-One Accelerates Alpha-Synuclein Degradation by Enhancing UPS Activity: Drug Target Identification by CRISPR-Cas9 Whole Genome-Wide Screening Technology[J]. FRONTIERS IN PHARMACOLOGY, 2019, 10.
Authors:  Ning-Ning Yuan;  Cui-Zan Cai;  Ming-Yue Wu;  Qi Zhu;  HuanXing Su; et al.
Favorite | TC[WOS]:17 TC[Scopus]:20  IF:4.4/5.0 | Submit date:2020/04/14
Canthin-6-one  Parkinson’s Disease  Alpha-synuclein  Ubiquitin-proteasome-system  Crispr/cas9  Rpn2/psmd1  Pka  
Corynoxine, a natural autophagy enhancer, promotes the clearance of alpha-synuclein via Akt/mTOR pathway Journal article
Chen L.-L., Song J.-X., Lu J.-H., Yuan Z.-W., Liu L.-F., Durairajan S.S.K., Li M.. Corynoxine, a natural autophagy enhancer, promotes the clearance of alpha-synuclein via Akt/mTOR pathway[J]. Journal of Neuroimmune Pharmacology, 2014, 9(3), 380-387.
Authors:  Chen L.-L.;  Song J.-X.;  Lu J.-H.;  Yuan Z.-W.;  Liu L.-F.; et al.
Favorite | TC[WOS]:78 TC[Scopus]:84 | Submit date:2019/01/15
Alpha-synuclein  Autophagy  Corynoxine  Mtor  Parkinson's Disease  
Baicalein Inhibits Formation of α-Synuclein Oligomers within Living Cells and Prevents Aβ Peptide Fibrillation and Oligomerisation Journal article
Lu J.-H., Ardah M.T., Durairajan S.S.K., Liu L.-F., Xie L.-X., Fong W.-F.D., Hasan M.Y., Huang J.-D., El-Agnaf O.M.A., Li M.. Baicalein Inhibits Formation of α-Synuclein Oligomers within Living Cells and Prevents Aβ Peptide Fibrillation and Oligomerisation[J]. ChemBioChem, 2011, 12(4), 615-624.
Authors:  Lu J.-H.;  Ardah M.T.;  Durairajan S.S.K.;  Liu L.-F.;  Xie L.-X.; et al.
Favorite | TC[WOS]:132 TC[Scopus]:157 | Submit date:2019/01/15
Alpha-synuclein  Amyloid Beta-peptides  Baicalein  Neurological Agents  Oligomerization