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Targeting autophagy in Alzheimer’s disease: Animal models and mechanisms Journal article
Zhang, Xiao Wen, Zhu, Xiang Xing, Tang, Dong Sheng, Lu, Jia Hong. Targeting autophagy in Alzheimer’s disease: Animal models and mechanisms[J]. Zoological Research, 2023, 44(6), 1132-1145.
Authors:  Zhang, Xiao Wen;  Zhu, Xiang Xing;  Tang, Dong Sheng;  Lu, Jia Hong
Favorite | TC[WOS]:11 TC[Scopus]:10  IF:4.0/4.5 | Submit date：2024/02/22
Alzheimer’s Disease  Animal Models  Autophagy  Aβ Metabolism  Tau Pathology  
Bulleyaconitine A is a sensitive substrate and competitive inhibitor of CYP3A4: One of the possible explanations for clinical adverse reactions Journal article
Li, Xiaocui, Ou, Xiaowen, Ni, Jiadong, Xu, Yihong, Zuo, Huilin, Fu, Yu, Yang, Caihua, Zhao, Zhongxiang, Li, Na, Zhou, Hua, Zhang, Rong, Liu, Zhongqiu, Fu, Ling, Zhu, Lijun. Bulleyaconitine A is a sensitive substrate and competitive inhibitor of CYP3A4: One of the possible explanations for clinical adverse reactions[J]. Toxicology and Applied Pharmacology, 2022, 445.
Authors:  Li, Xiaocui;  Ou, Xiaowen;  Ni, Jiadong;  Xu, Yihong;  Zuo, Huilin; et al.
Favorite | TC[WOS]:2 TC[Scopus]:2  IF:3.3/3.6 | Submit date：2023/01/30
Adverse Reaction  Bulleyaconitine a  Cytochrome P450 Enzymes  Drug-drug Interactions  Human Liver Microsomes  Metabolism  
Targeting glucose metabolism to develop anticancer treatments and therapeutic patents Review article
2022
Authors:  Zhou, Yan;  Guo, Yizhen;  Tam, Kin Yip
Favorite | TC[WOS]:22 TC[Scopus]:21  IF:5.4/6.4 | Submit date：2022/05/17
Cancer Glucose Metabolism  Cancer Treatment Patent  Glycolytic Inhibitor  Hexokinase 2 (Hk2)  Lactate Dehydrogenase a (Ldha)  Pyruvate Dehydrogenase Kinase (Pdk)  Warburg Effect  
Targeting glucose metabolism to develop anticancer treatments and therapeutic patents Journal article
Zhou Yan, Guo Yizhen, TAM KIN YIP. Targeting glucose metabolism to develop anticancer treatments and therapeutic patents[J]. EXPERT OPINION ON THERAPEUTIC PATENTS, 2022, 32(4), 441-453.
Authors:  Zhou Yan;  Guo Yizhen;  TAM KIN YIP
Adobe PDF | Favorite | TC[WOS]:22 TC[Scopus]:21  IF:5.4/6.4 | Submit date：2024/08/29
Cancer Treatment Patent  Cancer Glucose Metabolism  Warburg Effect  Hexokinase 2 (Hk2)  Pyruvate Dehydrogenase Kinase (Pdk)  Lactate Dehydrogenase a (Ldha)  Glycolytic Inhibitor  
Development of dual inhibitors targeting pyruvate dehydrogenase kinases and human lactate dehydrogenase A: High-throughput virtual screening, synthesis and biological validation Journal article
Xiang,Sichuan, Huang,Ding, He,Qiaolin, Li,Jie, Tam,Kin Yip, Zhang,Shao Lin, He,Yun. Development of dual inhibitors targeting pyruvate dehydrogenase kinases and human lactate dehydrogenase A: High-throughput virtual screening, synthesis and biological validation[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 203, 112579.
Authors:  Xiang,Sichuan;  Huang,Ding;  He,Qiaolin;  Li,Jie;  Tam,Kin Yip; et al.
Favorite | TC[WOS]:13 TC[Scopus]:14  IF:6.0/6.1 | Submit date：2021/03/04
Cancer Metabolism  Cancer Proliferation  Dual Inhibitor  Lactate Dehydrogenase a  Pyruvate Dehydrogenase Kinase  
GLUT12 promotes prostate cancer cell growth and is regulated by androgens and CaMKK2 signaling Journal article
White, Mark A., Tsouko, Efrosini, Lin, Chenchu, Rajapakshe, Kimal, Spencer, Jeffrey M., Wilkenfeld, Sandi R., Vakili, Sheiva S., Pulliam, Thomas L., Awad, Dominik, Nikolos, Fotis, Katreddy, Rajasekhara Reddy, Kaipparettu, Benny Abraham, Sreekumar, Arun, Zhang, Xiaoliu, Cheung, Edwin, Coarfa, Cristian, Frigo, Daniel E.. GLUT12 promotes prostate cancer cell growth and is regulated by androgens and CaMKK2 signaling[J]. ENDOCRINE-RELATED CANCER, 2018, 25(4), 453-469.
Authors:  White, Mark A.;  Tsouko, Efrosini;  Lin, Chenchu;  Rajapakshe, Kimal;  Spencer, Jeffrey M.; et al.
Favorite | TC[WOS]:46 TC[Scopus]:47  IF:4.1/4.4 | Submit date：2018/10/30
Glut12  Slc2a12  Glucose Metabolism  Androgen Receptor (Ar)  Calcium/calmodulin-dependent Protein Kinase Kinase 2 (Camkk2)  5 '-amp-activated Protein Kinase (Ampk)  Prostate Cancer  
Metabolic characterization of (±)-praeruptorin A in vitro and in vivo by high performance liquid chromatography coupled with hybrid triple quadrupole-linear ion trap mass spectrometry and time-of-flight mass spectrometry Journal article
Song, Yue-Lin, Jing, Wang-Hui, Yan, Ru, Wang, Yi-Tao. Metabolic characterization of (±)-praeruptorin A in vitro and in vivo by high performance liquid chromatography coupled with hybrid triple quadrupole-linear ion trap mass spectrometry and time-of-flight mass spectrometry[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2014, 90(5), 98-110.
Authors:  Song, Yue-Lin;  Jing, Wang-Hui;  Yan, Ru;  Wang, Yi-Tao
View | Adobe PDF | Favorite | TC[WOS]:25 TC[Scopus]:25  IF:3.1/3.1 | Submit date：2018/11/01
(+/-)-praeruptorin a  Metabolism  Lightsight (Tm) Software  In Vivo  Peucedani Radix  
Identification of cytochrome P450 isoenzymes involved in metabolism of (+)-praeruptorin A, a calcium channel blocker, by human liver microsomes using ultra high-performance liquid chromatography coupled with tandem mass spectrometry Journal article
Jing W.-H., Song Y.-L., Yan R., Wang Y.-T.. Identification of cytochrome P450 isoenzymes involved in metabolism of (+)-praeruptorin A, a calcium channel blocker, by human liver microsomes using ultra high-performance liquid chromatography coupled with tandem mass spectrometry[J]. Journal of Pharmaceutical and Biomedical Analysis, 2013, 77, 175.
Authors:  Jing W.-H.;  Song Y.-L.;  Yan R.;  Wang Y.-T.
Favorite | TC[WOS]:19 TC[Scopus]:18  IF:3.1/3.1 | Submit date：2018/10/31
(+)-praeruptorin a  Angular-type Pyranocoumarins  Cytochrome Cyp 3a4  Metabolism  Human Liver Microsomes  Uhplc-qt-ms/ms  Chinese Medicines  Peucedani Radix  
Regulation of human pregnane X receptor and its target gene cytochrome P450 3A4 by Chinese herbal compounds and a molecular docking study Journal article
Liu, YH (Liu, Ya-He), Mo, SL (Mo, Sui-Lin), Bi, HC (Bi, Hui-Chang), Hu, BF (Hu, Bing-Fang), Li, CG (Li, Chun Guang), Wang, YT (Wang, Yi-Tao), Huang, L (Huang, Ling), Huang, M (Huang, Min), Duan, W (Duan, Wei), Liu, JP (Liu, Jun-Ping), Wei, MQ (Wei, Ming Qian), Zhou, SF (Zhou, Shu-Feng). Regulation of human pregnane X receptor and its target gene cytochrome P450 3A4 by Chinese herbal compounds and a molecular docking study[J]. XENOBIOTICA, 2011, 41(4), 259-280.
Authors:  Liu, YH (Liu, Ya-He);  Mo, SL (Mo, Sui-Lin);  Bi, HC (Bi, Hui-Chang);  Hu, BF (Hu, Bing-Fang);  Li, CG (Li, Chun Guang); et al.
Favorite | TC[WOS]:46 TC[Scopus]:48  IF:1.3/1.4 | Submit date：2018/11/01
Constitutive Androstane Receptor  Primary Human Hepatocytes  Corepressor Silencing-mediator  Hepatoma-cell Lines  Human Cyp3a4 Gene  Nuclear Receptor  Drug-metabolism  Transcriptional Activation  Xenobiotic Receptor  Interindividual Variability  
Transport and metabolism of (±)-praeruptorin A in Caco-2 cell monolayers Journal article
Jing W.H., Song Y.L., Yan R., Bi H.C., Li P.T., Wang Y.T.. Transport and metabolism of (±)-praeruptorin A in Caco-2 cell monolayers[J]. Xenobiotica, 2011, 41(1), 71.
Authors:  Jing W.H.;  Song Y.L.;  Yan R.;  Bi H.C.;  Li P.T.; et al.
Favorite | TC[WOS]:20 TC[Scopus]:21  IF:1.3/1.4 | Submit date：2018/10/31
(±)-praeruptorin a  Caco-2 Cells  Enantioselectivity  Hydrolysis  Metabolism  Transport