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Novel C. elegans models of Lewy body disease reveal pathological protein interactions and widespread miRNA dysregulation Journal article
Li, Rongzhen, Huang, Xiaobing, Shen, Linjing, Zhang, Tianjiao, Liu, Ning, Hou, Xiangqing, Wong, Garry. Novel C. elegans models of Lewy body disease reveal pathological protein interactions and widespread miRNA dysregulation[J]. Cellular and Molecular Life Sciences, 2024, 81(1), 377.
Authors:  Li, Rongzhen;  Huang, Xiaobing;  Shen, Linjing;  Zhang, Tianjiao;  Liu, Ning; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:6.2/7.7 | Submit date：2024/10/10
Amyloid β  Parkinson’s Disease  Tar-dna-binding Protein 43  Tau Protein  Α-synuclein  
Rasagiline Exerts Neuroprotection towards Oxygen–Glucose-Deprivation/Reoxygenation-Induced GAPDH-Mediated Cell Death by Activating Akt/Nrf2 Signaling Journal article
Lecht, Shimon, Lahiani, Adi, Klazas, Michal, Naamneh, Majdi Saleem, Rubin, Limor, Dong, Jiayi, Zheng, Wenhua, Lazarovici, Philip. Rasagiline Exerts Neuroprotection towards Oxygen–Glucose-Deprivation/Reoxygenation-Induced GAPDH-Mediated Cell Death by Activating Akt/Nrf2 Signaling[J]. Biomedicines, 2024, 12(7), 1592.
Authors:  Lecht, Shimon;  Lahiani, Adi;  Klazas, Michal;  Naamneh, Majdi Saleem;  Rubin, Limor; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:3.9/4.1 | Submit date：2024/08/05
Akt  Cell Death  Gapdh  Ischemia-like Insult  Neuroprotection  Nrf2  Phosphorylation  Rasagiline  Ros  Pc 12 Neuronal Model  Α-synuclein  Parkinson’s Disease  Stroke  
Tetramethylpyrazine Nitrone Promotes the Clearance of Alpha-Synuclein via Nrf2-Mediated Ubiquitin–Proteasome System Activation Journal article
Guo, Baojian, Zheng, Chengyou, Cao, Jie, Qiu, Xiaoling, Luo, Fangcheng, Li, Haitao, Lee, Simon Mingyuan, Yang, Xifei, Zhang, Gaoxiao, Sun, Yewei, Zhang, Zaijun, Wang, Yuqiang. Tetramethylpyrazine Nitrone Promotes the Clearance of Alpha-Synuclein via Nrf2-Mediated Ubiquitin–Proteasome System Activation[J]. NeuroMolecular Medicine, 2024, 26(1), 9.
Authors:  Guo, Baojian;  Zheng, Chengyou;  Cao, Jie;  Qiu, Xiaoling;  Luo, Fangcheng; et al.
Favorite | TC[WOS]:1 TC[Scopus]:1  IF:3.3/3.6 | Submit date：2024/05/16
Nuclear Factor Erythroid-2-related Factor 2  Parkinson’s Disease  Peroxisome Proliferator-activated Receptor γ Co-activator 1α  Tetramethylpyrazine Nitrone  Ubiquitin–proteasome System  Α-synuclein  
Antagonizing pathological α-synuclein-mediated neurodegeneration by J24335 via the activation of immunoproteasome Journal article
Pan, Zhijian, Yu, Chao Wu, Zhao, Chen, Shao, Min, Yang, Xuanjun, Liang, Xiaonan, Li, Haitao, Lu, Yucong, Ye, Qingqing, Chern, Ji Wang, Lu, Jiahong, Zhou, Hefeng, Lee, Simon Ming Yuen. Antagonizing pathological α-synuclein-mediated neurodegeneration by J24335 via the activation of immunoproteasome[J]. Toxicology and Applied Pharmacology, 2023, 480, 116745.
Authors:  Pan, Zhijian;  Yu, Chao Wu;  Zhao, Chen;  Shao, Min;  Yang, Xuanjun; et al.
Favorite | TC[WOS]:1 TC[Scopus]:1  IF:3.3/3.6 | Submit date：2024/01/02
Immunoproteasome  J24335  Lmp7  Parkinson's Disease  Protein Degradation  Α-synuclein  
Corynoxine B targets at HMGB1/2 to enhance autophagy for α-synuclein clearance in fly and rodent models of Parkinson's disease Journal article
Qi Zhu, Juxian Song, Jia-Yue Chen, Zhenwei Yuan, Liangfeng Liu, Li-Ming Xie, Qiwen Liao, Richard D. Ye, Xiu Chen, Yepiao Yan, Jieqiong Tan, Chris Soon Heng Tan, Min Li, Jia-Hong Lu. Corynoxine B targets at HMGB1/2 to enhance autophagy for α-synuclein clearance in fly and rodent models of Parkinson's disease[J]. Acta Pharmaceutica Sinica B, 2023, 13(6), 2701-2714.
Authors:  Qi Zhu;  Juxian Song;  Jia-Yue Chen;  Zhenwei Yuan;  Liangfeng Liu; et al.
Favorite | TC[WOS]:7 TC[Scopus]:7  IF:14.7/14.1 | Submit date：2023/07/20
Autophagy  Corynoxine b  Hmgb1  Hmgb2  Neurodegenerative Disease  Parkinson's Disease  Pi3kc3  Α-synuclein  
“Swiss Army Knife” black phosphorus-based nanodelivery platform for synergistic antiparkinsonian therapy via remodeling the brain microenvironment Journal article
Guowang Cheng, Zhongjun Li, Yujing Liu, Rui Ma, Xiaojia Chen, Wen Liu, Yafang Song, Yuan Zhang, Guangtao Yu, Zhenfeng Wu, Tongkai Chen. “Swiss Army Knife” black phosphorus-based nanodelivery platform for synergistic antiparkinsonian therapy via remodeling the brain microenvironment[J]. Journal of Controlled Release, 2022, 353, 752-766.
Authors:  Guowang Cheng;  Zhongjun Li;  Yujing Liu;  Rui Ma;  Xiaojia Chen; et al.
Favorite | TC[WOS]:11 TC[Scopus]:13  IF:10.5/10.6 | Submit date：2023/02/01
Parkinson's Disease  Neuroinflammation  Α-synuclein  Blood-brain Barrier  Black Phosphorus Nanosheets  Neuroprotection  
The effects of bioactive components from the rhizome of gastrodia elata blume (Tianma) on the characteristics of Parkinson’s disease Journal article
Lu, Changcheng, Qu, Shuhui, Zhong, Zhangfeng, Luo, Hua, Lei, Si San, Zhong, Hai Jing, Su, Huanxing, Wang, Yitao, Chong, Cheong Meng. The effects of bioactive components from the rhizome of gastrodia elata blume (Tianma) on the characteristics of Parkinson’s disease[J]. Frontiers in Pharmacology, 2022, 13, 963327.
Authors:  Lu, Changcheng;  Qu, Shuhui;  Zhong, Zhangfeng;  Luo, Hua;  Lei, Si San; et al.
Favorite | TC[WOS]:18 TC[Scopus]:20  IF:4.4/5.0 | Submit date：2023/01/30
Dopaminergic Neurons  Neuroinflmamation  Parkisnon’s Disease  Synuclein  Tianma (Gastrodia Elata Blume)  
Chaperone-Mediated Autophagy in Neurodegenerative Diseases: Molecular Mechanisms and Pharmacological Opportunities Journal article
Wang, Yi Ting, Lu, Jia Hong. Chaperone-Mediated Autophagy in Neurodegenerative Diseases: Molecular Mechanisms and Pharmacological Opportunities[J]. Cells, 2022, 11(14), 2250.
Authors:  Wang, Yi Ting;  Lu, Jia Hong
Favorite | TC[WOS]:25 TC[Scopus]:24  IF:5.1/6.0 | Submit date：2022/08/24
Alzheimer’s Disease  Autophagy  Chaperone-mediated Autophagy  Hsc70  Huntington’s Disease  Lamp2a  Neurodegenerative Disease  Parkinson’s Disease  Small Molecule  Α-synuclein  
α-mangostin derivative 4e as a PDE4 inhibitor promote proteasomal degradation of alpha-synuclein in Parkinson's disease models through PKA activation Journal article
Chen, Jia Yue, Zhu, Qi, Cai, Cui Zan, Luo, Hai Bin, Lu, Jia Hong. α-mangostin derivative 4e as a PDE4 inhibitor promote proteasomal degradation of alpha-synuclein in Parkinson's disease models through PKA activation[J]. Phytomedicine, 2022, 101, 154125.
Authors:  Chen, Jia Yue;  Zhu, Qi;  Cai, Cui Zan;  Luo, Hai Bin;  Lu, Jia Hong
Favorite | TC[WOS]:8 TC[Scopus]:8  IF:6.7/6.2 | Submit date：2022/05/31
Alpha-synuclein (Α-syn)  Parkinson's Disease  Phosphodiesterase 4 Inhibitor  Protein Kinase a (Pka)  Ubiquitin-proteasome System (Ups)  
Black Phosphorus-Based Nanotherapeutics to Overcome the Blood-Brain Barrier for Parkinson's Disease Conference paper
Cheng, Guowang, Luo, Jingshan, Liu, Yao, Chen, Xiaojia, Wu, Zhenfeng, Chen, Tongkai. Black Phosphorus-Based Nanotherapeutics to Overcome the Blood-Brain Barrier for Parkinson's Disease[C], Guangzhou:The 7th Nano Today Conference, 2021.
Authors:  Cheng, Guowang;  Luo, Jingshan;  Liu, Yao;  Chen, Xiaojia;  Wu, Zhenfeng; et al.
Favorite |  | Submit date：2022/08/02
Black Phosphorus Nanosheets  Blood-brain Barrier  Noninvasive Targeted Delivery  Α-synuclein