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Ivacaftor, a CFTR potentiator, synergizes with osimertinib against acquired resistance to osimertinib in NSCLC by regulating CFTR-PTEN-AKT axis Journal article
Li, Yue Kang, Ge, Fu Jing, Liu, Xiang Ning, Zeng, Chen Ming, Qian, Mei Jia, Li, Yong Hao, Zheng, Ming Ming, Qu, Jing Jing, Fang, Liang Jie, Lu, Jin Jian, Yang, Bo, He, Qiao Jun, Zhou, Jian Ya, Zhu, Hong. Ivacaftor, a CFTR potentiator, synergizes with osimertinib against acquired resistance to osimertinib in NSCLC by regulating CFTR-PTEN-AKT axis[J]. Acta Pharmacologica Sinica, 2024.
Authors:  Li, Yue Kang;  Ge, Fu Jing;  Liu, Xiang Ning;  Zeng, Chen Ming;  Qian, Mei Jia; et al.
Favorite | TC[WOS]:0 TC[Scopus]:1  IF:6.9/7.6 | Submit date：2024/12/26
Acquired Resistance  Cftr  Ivacaftor  Nsclc  Osimertinib  
SP600125, a selective JNK inhibitor, is a potent inhibitor of NAD(P)H: quinone oxidoreductase 1 (NQO1) Journal article
Zhong, Bing Ling, Zhang, Yi Fei, Zheng, Hao Yi, Chen, Qiang, Lu, Hua Dong, Chen, Xiu Ping. SP600125, a selective JNK inhibitor, is a potent inhibitor of NAD(P)H: quinone oxidoreductase 1 (NQO1)[J]. Acta Pharmacologica Sinica, 2024.
Authors:  Zhong, Bing Ling;  Zhang, Yi Fei;  Zheng, Hao Yi;  Chen, Qiang;  Lu, Hua Dong; et al.
Favorite | TC[WOS]:0 TC[Scopus]:1  IF:6.9/7.6 | Submit date：2024/12/05
Jnk  Nqo1  Sp600125  
E3 ubiquitin ligase UBR5 modulates circadian rhythm by facilitating the ubiquitination and degradation of the key clock transcription factor BMAL1 Journal article
Duan, Chunyan, Li, Yue, Zhi, Haoyu, Tian, Yao, Huang, Zhengyun, Chen, Suping, Zhang, Yang, Liu, Qing, Zhou, Liang, Jiang, Xiaogang, Ullah, Kifayat, Guo, Qing, Liu, Zhaohui, Xu, Ying, Han, Junhai, Hou, Jiajie, O’Connor, Darran P., Xu, Guo qiang. E3 ubiquitin ligase UBR5 modulates circadian rhythm by facilitating the ubiquitination and degradation of the key clock transcription factor BMAL1[J]. ACTA PHARMACOLOGICA SINICA, 2024, 45(9), 1793-1808.
Authors:  Duan, Chunyan;  Li, Yue;  Zhi, Haoyu;  Tian, Yao;  Huang, Zhengyun; et al.
Favorite | TC[WOS]:2 TC[Scopus]:1  IF:6.9/7.6 | Submit date：2024/06/05
Bmal1  Circadian Rhythm  Proteomics  Transcriptional Activity  Ubiquitination  Ubr5  
Novel STAT3 oligonucleotide compounds suppress tumor growth and overcome the acquired resistance to sorafenib in hepatocellular carcinoma Journal article
Zhang, Qi Yi, Ding, Wen, Mo, Jian Shan, Ou-yang, Shu Min, Lin, Zi You, Peng, Ke Ren, Liu, Guo Pin, Lu, Jin Jian, Yue, Pei Bin, Lei, Jin Ping, Wang, Yan Dong, Zhang, Xiao Lei. Novel STAT3 oligonucleotide compounds suppress tumor growth and overcome the acquired resistance to sorafenib in hepatocellular carcinoma[J]. ACTA PHARMACOLOGICA SINICA, 2024.
Authors:  Zhang, Qi Yi;  Ding, Wen;  Mo, Jian Shan;  Ou-yang, Shu Min;  Lin, Zi You; et al.
Favorite | TC[WOS]:6 TC[Scopus]:7  IF:6.9/7.6 | Submit date：2024/05/16
Acquired Sorafenib-resistance  Antisense Oligonucleotide  Hepatocellular Carcinoma  Stat3  
Paraptosis: a non-classical paradigm of cell death for cancer therapy Review article
2024
Authors:  Xu, Chun cao;  Lin, Yi fan;  Huang, Mu yang;  Zhang, Xiao lei;  Wang, Pei; et al.
Favorite | TC[WOS]:21 TC[Scopus]:19  IF:6.9/7.6 | Submit date：2024/02/22
Cancer Therapy  Endoplasmic Reticulum  Er Stress  Mitochondria  Paraptosis  
14-Deoxygarcinol improves insulin sensitivity in high-fat diet-induced obese mice via mitigating NF-κB/Sirtuin 2-NLRP3-mediated adipose tissue remodeling Journal article
Jia-li Chen, Zhe-ling Feng, Fei Zhou, Ruo-han Lou, Cheng Peng, Yang Ye, Li-gen Lin. 14-Deoxygarcinol improves insulin sensitivity in high-fat diet-induced obese mice via mitigating NF-κB/Sirtuin 2-NLRP3-mediated adipose tissue remodeling[J]. Acta Pharmacologica Sinica, 2022, 44, 434–445.
Authors:  Jia-li Chen;  Zhe-ling Feng;  Fei Zhou;  Ruo-han Lou;  Cheng Peng; et al.
Favorite | TC[WOS]:11 TC[Scopus]:12  IF:6.9/7.6 | Submit date：2023/01/30
14-deoxygarcinol  Adipose Tissue Inflammation  Insulin Resistance  Interleukin-1β  Nlrp3 Inflammasome  Sirtuin 2  
Novel treatment for refractory rheumatoid arthritis with total glucosides of paeony and nobiletin codelivered in a self-nanoemulsifying drug delivery system Journal article
Qu, Biao, Wang, Xiao lin, Zheng, De chong, Mai, Chu tian, Liu, Zhong qiu, Zhou, Hua, Xie, Ying. Novel treatment for refractory rheumatoid arthritis with total glucosides of paeony and nobiletin codelivered in a self-nanoemulsifying drug delivery system[J]. Acta Pharmacologica Sinica, 2022, 43(8), 2094-2108.
Authors:  Qu, Biao;  Wang, Xiao lin;  Zheng, De chong;  Mai, Chu tian;  Liu, Zhong qiu; et al.
Favorite | TC[WOS]:12 TC[Scopus]:10  IF:6.9/7.6 | Submit date：2023/01/30
Nobiletin  P-glycoprotein  Refractory Rheumatoid Arthritis  Self-nanoemulsifying Drug Delivery Systems  Total Glucosides Of Paeony  
The challenges and opportunities of traditional Chinese medicines against COVID-19: a way out from a network perspective Journal article
Zuo, Hua li, Lin, Yang Chi Dung, Huang, Hsi Yuan, Wang, Xu, Tang, Yun, Hu, Yuan jia, Kong, Xiang jun, Chen, Qian jun, Zhang, Yu zhu, Hong, Hsiao Chin, Li, Jing, Hu, Si yao, Huang, Hsien Da. The challenges and opportunities of traditional Chinese medicines against COVID-19: a way out from a network perspective[J]. ACTA PHARMACOLOGICA SINICA, 2021, 42(6), 845-847.
Authors:  Zuo, Hua li;  Lin, Yang Chi Dung;  Huang, Hsi Yuan;  Wang, Xu;  Tang, Yun; et al.
Favorite | TC[WOS]:7 TC[Scopus]:8  IF:6.9/7.6 | Submit date：2021/12/08
Garciesculenxanthone B induces PINK1-Parkin-mediated mitophagy and prevents ischemia-reperfusion brain injury in mice Journal article
Wu,Man, Lu,Guang, Lao,Yuan zhi, Zhang,Hong, Zheng,Dan, Zheng,Zhao qing, Yi,Juan, Xiang,Qian, Wang,Li ming, Tan,Hong sheng, Zhou,Hua, Shen,Han ming, Xu,Hong xi. Garciesculenxanthone B induces PINK1-Parkin-mediated mitophagy and prevents ischemia-reperfusion brain injury in mice[J]. Acta Pharmacologica Sinica, 2021, 42(2), 199-208.
Authors:  Wu,Man;  Lu,Guang;  Lao,Yuan zhi;  Zhang,Hong;  Zheng,Dan; et al.
Favorite | TC[WOS]:46 TC[Scopus]:48  IF:6.9/7.6 | Submit date：2021/03/02
Garciesculenxanthone b  Ischemia-reperfusion Injury  Mitophagy  Parkin  Pink1