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Pathogenic variants in human DNA damage repair genes mostly arose in recent human history Journal article
Zhao, Bojin, Li, Jiaheng, Sinha, Siddharth, Qin, Zixin, Kou, Si Hoi, Xiao, Fengxia, Lei, Huijun, Chen, Tianhui, Cao, Wenming, Ding, Xiaofan, Wang, San Ming. Pathogenic variants in human DNA damage repair genes mostly arose in recent human history[J]. BMC Cancer, 2024, 24(1), 415.
Authors:  Zhao, Bojin;  Li, Jiaheng;  Sinha, Siddharth;  Qin, Zixin;  Kou, Si Hoi; et al.
Favorite | TC[WOS]:3 TC[Scopus]:3  IF:3.4/3.8 | Submit date：2024/05/16
Archaeological  Dna Damage Repair  Evolutionary Origin  Pathogenic Variants  Phylogenetic  
Comprehensive classification of TP53 somatic missense variants based on their impact on p53 structural stability Journal article
Benjamin Tam, Philip Naderev P. Lagniton, Mariano da Luz, Bojin Zhao, Siddharth Sinha, Chon Lok Lei, San Ming Wang. Comprehensive classification of TP53 somatic missense variants based on their impact on p53 structural stability[J]. Briefings in Bioinformatics, 2024, 25(5), bbae400.
Authors:  Benjamin Tam;  Philip Naderev P. Lagniton;  Mariano da Luz;  Bojin Zhao;  Siddharth Sinha; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:6.8/7.9 | Submit date：2024/08/07
Ramachandran Plot  Molecular Dynamics Simulations  Tp53  Somatic Missense Variants  
Using Portuguese BRCA pathogenic variation as a model to study the impact of human admixture on human health Journal article
Andaluz, Stephanie, Zhao, Bojin, Sinha, Siddharth, Lagniton, Philip Naderev Panuringan, Costa, Diogo Alpuim, Ding, Xiaofan, Brito, Miguel, Wang, San Ming. Using Portuguese BRCA pathogenic variation as a model to study the impact of human admixture on human health[J]. BMC Genomics, 2024, 25(1), 416.
Authors:  Andaluz, Stephanie;  Zhao, Bojin;  Sinha, Siddharth;  Lagniton, Philip Naderev Panuringan;  Costa, Diogo Alpuim; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:3.5/4.1 | Submit date：2024/05/16
Admixture  Brca1  Brca2  Pathogenic Variants  Cancer Risk  Portuguese  Brazilian  
Evolutionary origin of germline pathogenic variants in human DNA mismatch repair genes Journal article
Lei, Huijun, Li, Jiaheng, Zhao, Bojin, Kou, Si Hoi, Xiao, Fengxia, Chen, Tianhui, Wang, San Ming. Evolutionary origin of germline pathogenic variants in human DNA mismatch repair genes[J]. Human Genomics, 2024, 18(1), 5.
Authors:  Lei, Huijun;  Li, Jiaheng;  Zhao, Bojin;  Kou, Si Hoi;  Xiao, Fengxia; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:3.8/4.0 | Submit date：2024/05/16
Ancient Genome  Conservation  Dna Mismatch Repair  Evolutionary Origin  Pathogenic Variant  
Classification of MLH1 Missense VUS Using Protein Structure-Based Deep Learning-Ramachandran Plot-Molecular Dynamics Simulations Method Journal article
Tam, Benjamin, Qin, Zixin, Zhao, Bojin, Sinha, Siddharth, Lei, Chon Lok, Wang, San Ming. Classification of MLH1 Missense VUS Using Protein Structure-Based Deep Learning-Ramachandran Plot-Molecular Dynamics Simulations Method[J]. International Journal of Molecular Sciences, 2024, 25(2), 850.
Authors:  Tam, Benjamin;  Qin, Zixin;  Zhao, Bojin;  Sinha, Siddharth;  Lei, Chon Lok; et al.
Favorite | TC[WOS]:3 TC[Scopus]:3  IF:4.9/5.6 | Submit date：2024/02/22
Autoencoder  Deep Learning  Mlh1  Molecular Dynamics Simulation  Neural Network  Ramachandran Plot  Vus  
TP53 germline pathogenic variants in modern humans were likely originated during recent human history Journal article
Si Hoi Kou, Jiaheng Li, Benjamin Tam,, Huijun Lei, Bojin Zhao, Fengxia Xiao, San Ming Wang. TP53 germline pathogenic variants in modern humans were likely originated during recent human history[J]. NAR Cancer, 2023, 5(3), zcad025.
Authors:  Si Hoi Kou;  Jiaheng Li;  Benjamin Tam,;  Huijun Lei;  Bojin Zhao; et al.
Favorite | TC[WOS]:7 TC[Scopus]:7  IF:3.4/4.1 | Submit date：2023/08/03
Integration of deep learning with Ramachandran plot molecular dynamics simulation for genetic variant classification Journal article
Tam, Benjamin, Qin, Zixin, Zhao, Bojin, Wang, San Ming, Lei, Chon Lok. Integration of deep learning with Ramachandran plot molecular dynamics simulation for genetic variant classification[J]. ISCIENCE, 2023, 26(3), 106122.
Authors:  Tam, Benjamin;  Qin, Zixin;  Zhao, Bojin;  Wang, San Ming;  Lei, Chon Lok
Favorite | TC[WOS]:5 TC[Scopus]:5  IF:4.6/5.0 | Submit date：2023/04/03
Ethnic-specificity, evolution origin and deleteriousness of Asian BRCA variation revealed by over 7500 BRCA variants derived from Asian population Journal article
Qin, Zixin, Li, Jiaheng, Tam, Benjamin, Sinha, Siddharth, Zhao, Bojin, Bhaskaran, Shanmuga Priya, Huang, Teng, Wu, Xiaobing, Chian, Jia Sheng, Guo, Maoni, Kou, Si Hoi, Lei, Huijun, Zhang, Li, Wang, Xiaoyu, Lagniton, Philip Naderev P., Xiao, Fengxia, Jiang, Xinyang, Wang, San Ming. Ethnic-specificity, evolution origin and deleteriousness of Asian BRCA variation revealed by over 7500 BRCA variants derived from Asian population[J]. International Journal of Cancer, 2022, 152(6), 1159-1173.
Authors:  Qin, Zixin;  Li, Jiaheng;  Tam, Benjamin;  Sinha, Siddharth;  Zhao, Bojin; et al.
Favorite | TC[WOS]:5 TC[Scopus]:6  IF:5.7/6.0 | Submit date：2023/01/30
Asian  Brca1  Brca2  Cancer  Database  Evolution  Germline Variation  Population  Structure  Variation  
Human BRCA pathogenic variants were originated during recent human history Journal article
Jiaheng Li, Bojin Zhao, Teng Huang, Zixin Qiu, San Ming Wang. Human BRCA pathogenic variants were originated during recent human history[J]. Life Science Alliance, 2022, 5(5).
Authors:  Jiaheng Li;  Bojin Zhao;  Teng Huang;  Zixin Qiu;  San Ming Wang
Favorite | TC[WOS]:16 TC[Scopus]:18  IF:3.3/3.8 | Submit date：2022/05/13
Ethnic-specific BRCA1/2 variation within Asia population: Evidence from over 78 000 cancer and 40 000 non-cancer cases of Indian, Chinese, Korean and Japanese populations Journal article
Shanmuga Priya Bhaskaran, Teng Huang, Barani Kumar Rajendran, Maoni Guo, Jiangtao Luo, Zixin Qin, Bojin Zhao, Jiasheng Chian, Suicheng Li, San Ming Wang. Ethnic-specific BRCA1/2 variation within Asia population: Evidence from over 78 000 cancer and 40 000 non-cancer cases of Indian, Chinese, Korean and Japanese populations[J]. Journal of Medical Genetics, 2021, 58(11), 752-759.
Authors:  Shanmuga Priya Bhaskaran;  Teng Huang;  Barani Kumar Rajendran;  Maoni Guo;  Jiangtao Luo; et al.
Favorite | TC[WOS]:26 TC[Scopus]:25  IF:3.5/4.1 | Submit date：2021/12/08
Dna Repair  Genetic Heterogeneity  Genetic Predisposition To Disease  Genetic Variation  Genetics  Medical