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Atavistic strategy for the treatment of hyperuricemia via ionizable liposomal mRNA Journal article
Zhang, Mengjie, Hussain, Abid, Hu, Bo, Yang, Haiyin, Li, Chunhui, Guo, Shuai, Han, Xiaofeng, Li, Bei, Dai, Yunlu, Cao, Yuhong, Chi, Hang, Weng, Yuhua, Qin, Cheng Feng, Huang, Yuanyu. Atavistic strategy for the treatment of hyperuricemia via ionizable liposomal mRNA[J]. Nature Communications, 2024, 15(1), 6463.
Authors:  Zhang, Mengjie;  Hussain, Abid;  Hu, Bo;  Yang, Haiyin;  Li, Chunhui; et al.
Favorite | TC[WOS]:4 TC[Scopus]:5  IF:14.7/16.1 | Submit date：2024/09/03
Serum Uric-acid  Urate Oxidase  Delivery  Sirna  Risk  Endocytosis  Therapy  
OGG1: An emerging multifunctional therapeutic target for the treatment of diseases caused by oxidative DNA damage Review article
2024
Authors:  Zhong, Yunxiao;  Zhang, Xinya;  Feng, Ruibing;  Fan, Yu;  Zhang, Zhang; et al.
Favorite | TC[WOS]:3 TC[Scopus]:3  IF:10.9/12.9 | Submit date：2024/09/03
8-oxoguanine Dna Glycosylase 1  Age-related Disorders  Inflammation  Oxidative Dna Damage-related Diseases  Tumors  
Encoding and display technologies for combinatorial libraries in drug discovery: The coming of age from biology to therapy Review article
2024
Authors:  Fan, Yu;  Feng, Ruibing;  Zhang, Xinya;  Wang, Zhen Liang;  Xiong, Feng; et al.
Favorite | TC[WOS]:8 TC[Scopus]:7  IF:14.7/14.1 | Submit date：2024/05/16
Drug Screening  Dna-encoded Chemical Libraries  Phage Display  Peptide-encoded Chemical Libraries  Clinical Drugs  
Small molecule α-methylene-γ-butyrolactone, an evolutionarily conserved moiety in sesquiterpene lactones, ameliorates arthritic phenotype via interference DNA binding activity of NF-κB Journal article
Linghu, Kegang, Cui, Wenqing, Li, Taiqin, Tuo, Yueting, Wang, Dasong, Pan, Huiqi, Zhang, Tian, Lin, Ligen, Yu, Hua, Hu, Xiaoxia, Li, Haiyang, Shen, Xiangchun. Small molecule α-methylene-γ-butyrolactone, an evolutionarily conserved moiety in sesquiterpene lactones, ameliorates arthritic phenotype via interference DNA binding activity of NF-κB[J]. Acta Pharmaceutica Sinica B, 2024, 14(8), 3561-3575.
Authors:  Linghu, Kegang;  Cui, Wenqing;  Li, Taiqin;  Tuo, Yueting;  Wang, Dasong; et al.
Favorite | TC[WOS]:6 TC[Scopus]:7  IF:14.7/14.1 | Submit date：2024/05/16
Α-methylene-γ-  Butyrolactone  Rheumatoid Arthritis  Nf-kb P65  Synovial  Microenvironment  Sesquiterpene Lactones  
Small molecule deoxynyboquinone triggers alkylation and ubiquitination of Keap1 at Cys489 on Kelch domain for Nrf2 activation and inflammatory therapy Journal article
Linghu, Ke-Gang, Zhang, Tian, Zhang, Guang-Tao, Lv, Peng, Zhang, Wenjun, Zhao, Guanding, Xiong, Shihong, Zhao, Mingming, Chen, Meiwan, HU YUANJIA, Zhang, Changsheng, Yu, Hua. Small molecule deoxynyboquinone triggers alkylation and ubiquitination of Keap1 at Cys489 on Kelch domain for Nrf2 activation and inflammatory therapy[J]. Journal of Pharmaceutical Analysis, 2024, 14(3), 401-415.
Authors:  Linghu, Ke-Gang;  Zhang, Tian;  Zhang, Guang-Tao;  Lv, Peng;  Zhang, Wenjun; et al.
Favorite | TC[WOS]:7 TC[Scopus]:9  IF:6.1/6.8 | Submit date：2024/01/02
Deoxynyboquinone  Anti-inflammation  Target  Keap1/nrf2  Alkylation  Ubiquitination  
A Biomimetic Multifunctional Nanoframework for Symptom Relief and Restorative Treatment of Acute Liver Failure Journal article
Feng, Ruibing, Fan, Yu, Zhang, Xinya, Chen, Lanmei, Zhong, Zhang Feng, Wang, Yitao, Yu, Hua, Zhang, Qing Wen, Li, Guodong. A Biomimetic Multifunctional Nanoframework for Symptom Relief and Restorative Treatment of Acute Liver Failure[J]. ACS Nano, 2024, 18(7), 5951-5964.
Authors:  Feng, Ruibing;  Fan, Yu;  Zhang, Xinya;  Chen, Lanmei;  Zhong, Zhang Feng; et al.
Favorite | TC[WOS]:5 TC[Scopus]:5  IF:15.8/16.2 | Submit date：2024/05/16
Acute Liver Failure  Biomimetic Nanoparticle  Mesenchymal Stem Cell  N-acetylcysteine  Rhein  
Portulaca Oleracea L. (Purslane) Extract Protects Endothelial Function by Reducing Endoplasmic Reticulum Stress and Oxidative Stress through AMPK Activation in Diabetic Obese Mice Journal article
Miao, Lingchao, Zhou, Chunxiu, Zhang, Haolin, Cheong, Meng Sam, Tan, Yi, Wang, Yuehan, Zhang, Xutao, Yu, Hua, Cheang, Wai San. Portulaca Oleracea L. (Purslane) Extract Protects Endothelial Function by Reducing Endoplasmic Reticulum Stress and Oxidative Stress through AMPK Activation in Diabetic Obese Mice[J]. Antioxidants, 2023, 12(12), 2132.
Authors:  Miao, Lingchao;  Zhou, Chunxiu;  Zhang, Haolin;  Cheong, Meng Sam;  Tan, Yi; et al.
Favorite | TC[WOS]:3 TC[Scopus]:4  IF:6.0/6.7 | Submit date：2024/01/02
Diabetes Mellitus  Endoplasmic Reticulum Stress  Endothelial Function  Nitric Oxide  Purslane  Reactive Oxygen Species  
Expanding potential targets of herbal chemicals by node2vec based on herb–drug interactions Journal article
Dai-yan Zhang, Wen-qing Cui, Ling Hou, Jing Yang, Li-yang Lyu, Ze-yu Wang, Ke-Gang Linghu, Wen-bin He, Hua Yu, Yuan-jia Hu. Expanding potential targets of herbal chemicals by node2vec based on herb–drug interactions[J]. Chinese Medicine (United Kingdom), 2023, 18(1), 64.
Authors:  Dai-yan Zhang;  Wen-qing Cui;  Ling Hou;  Jing Yang;  Li-yang Lyu; et al.
Favorite | TC[WOS]:1 TC[Scopus]:3  IF:5.3/5.5 | Submit date：2023/08/03
Cardiovascular Disease  Herb–drug Interaction  Link Prediction  Node2vec  Traditional Medicine  
Leocarpinolide B Attenuates Collagen Type II-Induced Arthritis by Inhibiting DNA Binding Activity of NF-κB Journal article
Linghu, Ke Gang, Zhao, Guan Ding, Zhang, Dai Yan, Xiong, Shi Hang, Wu, Guo Ping, Shen, Li Yu, Cui, Wen Qing, Zhang, Tian, Hu, Yuan Jia, Guo, Bing, Shen, Xiang Chun, Yu, Hua. Leocarpinolide B Attenuates Collagen Type II-Induced Arthritis by Inhibiting DNA Binding Activity of NF-κB[J]. Molecules (Basel, Switzerland), 2023, 28(10), 4241.
Authors:  Linghu, Ke Gang;  Zhao, Guan Ding;  Zhang, Dai Yan;  Xiong, Shi Hang;  Wu, Guo Ping; et al.
Favorite | TC[WOS]:4 TC[Scopus]:4  IF:4.2/4.6 | Submit date：2023/06/05
Leocarpinolide b  Nf-κb P65  Rheumatoid Arthritis  Sesquiterpene Lactone  Synovitis  
Effects of Cinobufagin on the Proliferation, Migration, and Invasion of H1299 Lung Cancer Cells Journal article
Mingna Sun, Dongyu Huang, Yun Liu, Haifang Chen, Hua Yu, Guobin Zhang, Qilei Chen, Hubiao Chen, Jianye Zhang. Effects of Cinobufagin on the Proliferation, Migration, and Invasion of H1299 Lung Cancer Cells[J]. Chemistry and Biodiversity, 2022, 20(1), e202200961.
Authors:  Mingna Sun;  Dongyu Huang;  Yun Liu;  Haifang Chen;  Hua Yu; et al.
Favorite | TC[WOS]:1 TC[Scopus]:4  IF:2.3/2.5 | Submit date：2023/02/08
Cinobufagin  H1299 Cell  Lung Cancer  Metastasis  Proliferation