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Chemical mitophagy modulators: Drug development strategies and novel regulatory mechanisms Journal article
Dong,Yu, Zhuang,Xu Xu, Wang,Yi Ting, Tan,Jieqiong, Feng,Du, Li,Min, Zhong,Qing, Song,Zhiyin, Shen,Han Ming, Fang,Evandro F., Lu,Jia Hong. Chemical mitophagy modulators: Drug development strategies and novel regulatory mechanisms[J]. Pharmacological Research, 2023, 194, 106835.
Authors:  Dong,Yu;  Zhuang,Xu Xu;  Wang,Yi Ting;  Tan,Jieqiong;  Feng,Du; et al.
Favorite | TC[WOS]:12 TC[Scopus]:11  IF:9.1/9.0 | Submit date：2023/08/03
Cancer  Cardiovascular Diseases  Drug Development  Metabolic Disorders  Mitophagy  Neurodegenerative Diseases  
Corynoxine B targets at HMGB1/2 to enhance autophagy for α-synuclein clearance in fly and rodent models of Parkinson's disease Journal article
Qi Zhu, Juxian Song, Jia-Yue Chen, Zhenwei Yuan, Liangfeng Liu, Li-Ming Xie, Qiwen Liao, Richard D. Ye, Xiu Chen, Yepiao Yan, Jieqiong Tan, Chris Soon Heng Tan, Min Li, Jia-Hong Lu. Corynoxine B targets at HMGB1/2 to enhance autophagy for α-synuclein clearance in fly and rodent models of Parkinson's disease[J]. Acta Pharmaceutica Sinica B, 2023, 13(6), 2701-2714.
Authors:  Qi Zhu;  Juxian Song;  Jia-Yue Chen;  Zhenwei Yuan;  Liangfeng Liu; et al.
Favorite | TC[WOS]:7 TC[Scopus]:7  IF:14.7/14.1 | Submit date：2023/07/20
Autophagy  Corynoxine b  Hmgb1  Hmgb2  Neurodegenerative Disease  Parkinson's Disease  Pi3kc3  Α-synuclein  
Corynoxine B derivative CB6 prevents Parkinsonian toxicity in mice by inducing PIK3C3 complex-dependent autophagy Journal article
Zhu, Zhou, Liu, Liang feng, Su, Cheng fu, Liu, Jia, Tong, Benjamin Chun Kit, Iyaswamy, Ashok, Krishnamoorthi, Senthilkumar, Sreenivasmurthy, Sravan Gopalkrishnashetty, Guan, Xin jie, Kan, Yu xuan, Xie, Wen jian, Zhao, Chen liang, Cheung, King ho, Lu, Jia hong, Tan, Jie qiong, Zhang, Hong jie, Song, Ju xian, Li, Min. Corynoxine B derivative CB6 prevents Parkinsonian toxicity in mice by inducing PIK3C3 complex-dependent autophagy[J]. Acta Pharmacologica Sinica, 2022, 43(10), 2511-2526.
Authors:  Zhu, Zhou;  Liu, Liang feng;  Su, Cheng fu;  Liu, Jia;  Tong, Benjamin Chun Kit; et al.
Favorite | TC[WOS]:25 TC[Scopus]:21  IF:6.9/7.6 | Submit date：2022/05/17
Autophagy  Corynoxine b  Dopaminergic Neuron  
Toosendanin, a late-stage autophagy inhibitor, sensitizes triple-negative breast cancer to irinotecan chemotherapy Journal article
Zhang, Shuang, Dong, Yu, Chen, Xiuping, Tan, Chris Soon Heng, Li, Min, Miao, Kai, Lu, Jia Hong. Toosendanin, a late-stage autophagy inhibitor, sensitizes triple-negative breast cancer to irinotecan chemotherapy[J]. Chinese Medicine, 2022, 17, 55.
Authors:  Zhang, Shuang;  Dong, Yu;  Chen, Xiuping;  Tan, Chris Soon Heng;  Li, Min; et al.
Favorite | TC[WOS]:11 TC[Scopus]:12  IF:5.3/5.5 | Submit date：2022/05/31
Apoptosis  Autophagy Inhibition  Irinotecan  Lysosome  Sn-38  Toosendanin  Triple-negative Breast Cancer  
TFEB, a master regulator of autophagy and biogenesis, unexpectedly promotes apoptosis in response to the cyclopentenone prostaglandin 15d-PGJ2 Journal article
Yang, Chuan bin, Liu, Jia, Tong, Benjamin Chun Kit, Wang, Zi ying, Zhu, Zhou, Su, Cheng fu, Sreenivasmurthy, Sravan Gopalkrishnashetty, Wu, Jia xi, Iyaswamy, Ashok, Krishnamoorthi, Senthilkumar, Huang, Shi ying, Cheung, King ho, Song, Ju xian, Tan, Jie qiong, Lu, Jia hong, Li, Min. TFEB, a master regulator of autophagy and biogenesis, unexpectedly promotes apoptosis in response to the cyclopentenone prostaglandin 15d-PGJ2[J]. Acta Pharmacologica Sinica, 2022, 43(5), 1251-1263.
Authors:  Yang, Chuan bin;  Liu, Jia;  Tong, Benjamin Chun Kit;  Wang, Zi ying;  Zhu, Zhou; et al.
Favorite | TC[WOS]:18 TC[Scopus]:19  IF:6.9/7.6 | Submit date：2022/05/13
15-deoxy-∆-12,14-prostaglandin J2 (15d-pgJ2)  Apoptosis  Atf4  Autophagy And Lysosome Biogenesis  Er Stress  Transcriptional Factor Eb (tfEb)  
Theranostic F-SLOH mitigates Alzheimer's disease pathology involving TFEB and ameliorates cognitive functions in Alzheimer's disease models Journal article
Iyaswamy, Ashok, Wang, Xueli, Krishnamoorthi, Senthilkumar, Kaliamoorthy, Venkatapathy, Sreenivasmurthy, Sravan G., Kumar Durairajan, Siva Sundara, Song, Ju Xian, Tong, Benjamin Chun kit, Zhu, Zhou, Su, Cheng Fu, Liu, Jia, Cheung, King Ho, Lu, Jia Hong, Tan, Jie Qiong, Li, Hung Wing, Wong, Man Shing, Li, Min. Theranostic F-SLOH mitigates Alzheimer's disease pathology involving TFEB and ameliorates cognitive functions in Alzheimer's disease models[J]. Redox Biology, 2022, 51, 102280.
Authors:  Iyaswamy, Ashok;  Wang, Xueli;  Krishnamoorthi, Senthilkumar;  Kaliamoorthy, Venkatapathy;  Sreenivasmurthy, Sravan G.; et al.
Favorite | TC[WOS]:47 TC[Scopus]:51  IF:10.7/11.7 | Submit date：2022/05/13
Theranostic  Alzheimer’s Disease  Aβ-targeting  Aβ-aggregate Inhibition  3xtg-ad  5xfad  
Self-powered smart patch promotes skin nerve regeneration and sensation restoration by delivering biological-electrical signals in program Journal article
Tan, Min hong, Xu, Xue han, Yuan, Tie jun, Hou, Xu, Wang, Jie, Jiang, Zhi hong, Peng, Li hua. Self-powered smart patch promotes skin nerve regeneration and sensation restoration by delivering biological-electrical signals in program[J]. Biomaterials, 2022, 283.
Authors:  Tan, Min hong;  Xu, Xue han;  Yuan, Tie jun;  Hou, Xu;  Wang, Jie; et al.
Favorite | TC[WOS]:25 TC[Scopus]:26  IF:12.8/13.1 | Submit date：2023/01/30
Bioloigcal-electrical Cues  Nerve Regeneration  Neural Differentiation  Programmed Delivery  Sensory Restoration  Smart Patch  
Enhancing autophagy maturation with CCZ1-MON1A complex alleviates neuropathology and memory defects in Alzheimer disease models Journal article
Cai, Cui Zan, Zhuang, Xu Xu, Zhu, Qi, Wu, Ming Yue, Su, Huanxing, Wang, Xiao Jin, Iyaswamy, Ashok, Yue, Zhenyu, Wang, Qian, Zhang, Bin, Xue, Yu, Tan, Jieqiong, Li, Min, He, Huanhuan, Lu, Jia Hong. Enhancing autophagy maturation with CCZ1-MON1A complex alleviates neuropathology and memory defects in Alzheimer disease models[J]. Theranostics, 2022, 12(4), 1738-1755.
Authors:  Cai, Cui Zan;  Zhuang, Xu Xu;  Zhu, Qi;  Wu, Ming Yue;  Su, Huanxing; et al.
Favorite | TC[WOS]:17 TC[Scopus]:15  IF:12.4/12.0 | Submit date：2022/05/17
Alzheimer's Disease  Aβ  Autophagy  Ccz1-mon1a  Rab7  
Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease Journal article
Tong, Benjamin Chun Kit, Wu, Aston Jiaxi, Huang, Alexis Shiying, Dong, Rui, Malampati, Sandeep, Iyaswamy, Ashok, Krishnamoorthi, Senthilkumar, Sreenivasmurthy, Sravan Gopalkrishnashetty, Zhu, Zhou, Su, Chengfu, Liu, Jia, Song, Juxian, Lu, Jia Hong, Tan, Jieqiong, Pan, Weidong, Li, Min, Cheung, King Ho. Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease[J]. Autophagy, 2021, 18(3), 624-642.
Authors:  Tong, Benjamin Chun Kit;  Wu, Aston Jiaxi;  Huang, Alexis Shiying;  Dong, Rui;  Malampati, Sandeep; et al.
Favorite | TC[WOS]:30 TC[Scopus]:30  IF:14.6/16.8 | Submit date：2022/05/17
Alzheimer Disease  Autophagy-lysosomal Pathway  Calcium Ion  Presenilin-1  Two Pore Segment Channel 2  
PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation Journal article
Wu,Ming Yue, Liu,Le, Wang,Er Jin, Xiao,Hai Tao, Cai,Cui Zan, Wang,Jing, Su,Huanxing, Wang,Yitao, Tan,Jieqiong, Zhang,Zhuohua, Wang,Juan, Yao,Maojing, Ouyang,De Fang, Yue,Zhenyu, Li,Min, Chen,Ye, Bian,Zhao Xiang, Lu,Jia Hong. PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation[J]. Autophagy, 2021, 17(5), 1096-1111.
Authors:  Wu,Ming Yue;  Liu,Le;  Wang,Er Jin;  Xiao,Hai Tao;  Cai,Cui Zan; et al.
Favorite | TC[WOS]:56 TC[Scopus]:51  IF:14.6/16.8 | Submit date：2021/03/01
Apoptotic Cell Clearance  Inflammatory Bowel Disease  Macrophage  Mon1-ccz1  Nrbf2  Rab7