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Corynoxine B derivative CB6 prevents Parkinsonian toxicity in mice by inducing PIK3C3 complex-dependent autophagy Journal article
Zhu, Zhou, Liu, Liang feng, Su, Cheng fu, Liu, Jia, Tong, Benjamin Chun Kit, Iyaswamy, Ashok, Krishnamoorthi, Senthilkumar, Sreenivasmurthy, Sravan Gopalkrishnashetty, Guan, Xin jie, Kan, Yu xuan, Xie, Wen jian, Zhao, Chen liang, Cheung, King ho, Lu, Jia hong, Tan, Jie qiong, Zhang, Hong jie, Song, Ju xian, Li, Min. Corynoxine B derivative CB6 prevents Parkinsonian toxicity in mice by inducing PIK3C3 complex-dependent autophagy[J]. Acta Pharmacologica Sinica, 2022, 43(10), 2511-2526.
Authors:  Zhu, Zhou;  Liu, Liang feng;  Su, Cheng fu;  Liu, Jia;  Tong, Benjamin Chun Kit; et al.
Favorite | TC[WOS]:25 TC[Scopus]:21  IF:6.9/7.6 | Submit date：2022/05/17
Autophagy  Corynoxine b  Dopaminergic Neuron  
TFEB, a master regulator of autophagy and biogenesis, unexpectedly promotes apoptosis in response to the cyclopentenone prostaglandin 15d-PGJ2 Journal article
Yang, Chuan bin, Liu, Jia, Tong, Benjamin Chun Kit, Wang, Zi ying, Zhu, Zhou, Su, Cheng fu, Sreenivasmurthy, Sravan Gopalkrishnashetty, Wu, Jia xi, Iyaswamy, Ashok, Krishnamoorthi, Senthilkumar, Huang, Shi ying, Cheung, King ho, Song, Ju xian, Tan, Jie qiong, Lu, Jia hong, Li, Min. TFEB, a master regulator of autophagy and biogenesis, unexpectedly promotes apoptosis in response to the cyclopentenone prostaglandin 15d-PGJ2[J]. Acta Pharmacologica Sinica, 2022, 43(5), 1251-1263.
Authors:  Yang, Chuan bin;  Liu, Jia;  Tong, Benjamin Chun Kit;  Wang, Zi ying;  Zhu, Zhou; et al.
Favorite | TC[WOS]:18 TC[Scopus]:19  IF:6.9/7.6 | Submit date：2022/05/13
15-deoxy-∆-12,14-prostaglandin J2 (15d-pgJ2)  Apoptosis  Atf4  Autophagy And Lysosome Biogenesis  Er Stress  Transcriptional Factor Eb (tfEb)  
Theranostic F-SLOH mitigates Alzheimer's disease pathology involving TFEB and ameliorates cognitive functions in Alzheimer's disease models Journal article
Iyaswamy, Ashok, Wang, Xueli, Krishnamoorthi, Senthilkumar, Kaliamoorthy, Venkatapathy, Sreenivasmurthy, Sravan G., Kumar Durairajan, Siva Sundara, Song, Ju Xian, Tong, Benjamin Chun kit, Zhu, Zhou, Su, Cheng Fu, Liu, Jia, Cheung, King Ho, Lu, Jia Hong, Tan, Jie Qiong, Li, Hung Wing, Wong, Man Shing, Li, Min. Theranostic F-SLOH mitigates Alzheimer's disease pathology involving TFEB and ameliorates cognitive functions in Alzheimer's disease models[J]. Redox Biology, 2022, 51, 102280.
Authors:  Iyaswamy, Ashok;  Wang, Xueli;  Krishnamoorthi, Senthilkumar;  Kaliamoorthy, Venkatapathy;  Sreenivasmurthy, Sravan G.; et al.
Favorite | TC[WOS]:47 TC[Scopus]:51  IF:10.7/11.7 | Submit date：2022/05/13
Theranostic  Alzheimer’s Disease  Aβ-targeting  Aβ-aggregate Inhibition  3xtg-ad  5xfad  
Lycorine, a natural alkaloid, promotes the degradation of alpha-synuclein via PKA-mediated UPS activation in transgenic Parkinson's disease models Journal article
Zhu, Qi, Zhuang, Xu xu, Chen, Jia yue, Yuan, Ning ning, Chen, Yan, Cai, Cui zan, Tan, Jie qiong, Su, Huan xing, Lu, Jia hong. Lycorine, a natural alkaloid, promotes the degradation of alpha-synuclein via PKA-mediated UPS activation in transgenic Parkinson's disease models[J]. Phytomedicine, 2021, 87, 153578.
Authors:  Zhu, Qi;  Zhuang, Xu xu;  Chen, Jia yue;  Yuan, Ning ning;  Chen, Yan; et al.
Favorite | TC[WOS]:16 TC[Scopus]:18  IF:6.7/6.2 | Submit date：2021/12/08
Camp/pka Pathway  Lycorine  Parkinson's Disease  Ubiquitin-proteasome System  Α-synuclein  
NRBF2 is a RAB7 effector required for autophagosome maturation and mediates the association of APP-CTFs with active form of RAB7 for degradation Journal article
Cai,Cui Zan, Yang,Chuanbin, Zhuang,Xu Xu, Yuan,Ning Ning, Wu,Ming Yue, Tan,Jie Qiong, Song,Ju Xian, Cheung,King Ho, Su,Huanxing, Wang,Yi Tao, Tang,Bei Sha, Behrends,Christian, Durairajan,Siva Sundara Kumar, Yue,Zhenyu, Li,Min, Lu,Jia Hong. NRBF2 is a RAB7 effector required for autophagosome maturation and mediates the association of APP-CTFs with active form of RAB7 for degradation[J]. Autophagy, 2020, 17(5), 1112-1130.
Authors:  Cai,Cui Zan;  Yang,Chuanbin;  Zhuang,Xu Xu;  Yuan,Ning Ning;  Wu,Ming Yue; et al.
Favorite | TC[WOS]:30 TC[Scopus]:33  IF:14.6/16.8 | Submit date：2021/03/01
Amaturation  Autophagy  Ccz1-mon1a  Nrbf2  Pi3kc3/ Vps34  Rab7  Trafficking  
Pharmacological enhancement of TFEB-mediated autophagy alleviated neuronal death in oxidative stress-induced Parkinson’s disease models Journal article
Zhuang,Xu Xu, Wang,Sheng Fang, Tan,Yuan, Song,Ju Xian, Zhu,Zhou, Wang,Zi Ying, Wu,Ming Yue, Cai,Cui Zan, Huang,Zhi Jian, Tan,Jie Qiong, Su,Huan Xing, Li,Min, Lu,Jia Hong. Pharmacological enhancement of TFEB-mediated autophagy alleviated neuronal death in oxidative stress-induced Parkinson’s disease models[J]. Cell Death and Disease, 2020, 11(2), 128.
Authors:  Zhuang,Xu Xu;  Wang,Sheng Fang;  Tan,Yuan;  Song,Ju Xian;  Zhu,Zhou; et al.
Favorite | TC[WOS]:87 TC[Scopus]:88  IF:8.1/8.6 | Submit date：2021/03/01
Natural alkaloid harmine promotes degradation of alpha-synuclein via PKA-mediated ubiquitin-proteasome system activation Journal article
Cai,Cui Zan, Zhou,He Feng, Yuan,Ning Ning, Wu,Ming Yue, Lee,Simon Ming Yuen, Ren,Jiao Yan, Su,Huan Xing, Lu,Jin Jian, Chen,Xiu Ping, Li,Min, Tan,Jie Qiong, Lu,Jia Hong. Natural alkaloid harmine promotes degradation of alpha-synuclein via PKA-mediated ubiquitin-proteasome system activation[J]. Phytomedicine, 2019, 61.
Authors:  Cai,Cui Zan;  Zhou,He Feng;  Yuan,Ning Ning;  Wu,Ming Yue;  Lee,Simon Ming Yuen; et al.
Favorite | TC[WOS]:33 TC[Scopus]:38  IF:6.7/6.2 | Submit date：2021/03/01
-synuclein  Harmine  Parkinson's Disease  Protein Kinase a  Ubiquitin-proteasome System  
High content screening for drug discovery from traditional Chinese medicine Journal article
Wang,Jing, Wu,Ming Yue, Tan,Jie Qiong, Li,Min, Lu,Jia Hong. High content screening for drug discovery from traditional Chinese medicine[J]. Chinese Medicine, 2019, 14, 5.
Authors:  Wang,Jing;  Wu,Ming Yue;  Tan,Jie Qiong;  Li,Min;  Lu,Jia Hong
Favorite | TC[WOS]:17 TC[Scopus]:19  IF:5.3/5.5 | Submit date：2021/03/02
Advanced Models  Drug Discovery  High-content Screening  Progressive Instruments  Traditional Chinese Medicine  
Canthin-6-One Accelerates Alpha-Synuclein Degradation by Enhancing UPS Activity: Drug Target Identification by CRISPR-Cas9 Whole Genome-Wide Screening Technology Journal article
Ning-Ning Yuan, Cui-Zan Cai, Ming-Yue Wu, Qi Zhu, HuanXing Su, Min Li, JiaoYan Ren, Jie-Qiong Tan, Jia-Hong Lu. Canthin-6-One Accelerates Alpha-Synuclein Degradation by Enhancing UPS Activity: Drug Target Identification by CRISPR-Cas9 Whole Genome-Wide Screening Technology[J]. FRONTIERS IN PHARMACOLOGY, 2019, 10.
Authors:  Ning-Ning Yuan;  Cui-Zan Cai;  Ming-Yue Wu;  Qi Zhu;  HuanXing Su; et al.
Favorite | TC[WOS]:17 TC[Scopus]:20  IF:4.4/5.0 | Submit date：2020/04/14
Canthin-6-one  Parkinson’s Disease  Alpha-synuclein  Ubiquitin-proteasome-system  Crispr/cas9  Rpn2/psmd1  Pka  
Natural autophagy blockers, dauricine (DAC) and daurisoline (DAS), sensitize cancer cells to camptothecin-induced toxicity Journal article
Wu, Ming-Yue, Wang, Sheng-Fang, Cai, Cui-Zan, Tan, Jie-Qiong, Li, Min, Lu, Jin-Jian, Chen, Xiu-Ping, Wang, Yi-Tao, Zheng, Wei, Lu, Jia-Hong. Natural autophagy blockers, dauricine (DAC) and daurisoline (DAS), sensitize cancer cells to camptothecin-induced toxicity[J]. ONCOTARGET, 2017, 8(44), 77673-77684.
Authors:  Wu, Ming-Yue;  Wang, Sheng-Fang;  Cai, Cui-Zan;  Tan, Jie-Qiong;  Li, Min; et al.
Favorite | TC[WOS]:31 TC[Scopus]:38  IF:5.168/5.312 | Submit date：2018/10/30
Dauricine  Daurisoline  Autophagy Blocker  Cancer Cells  Cell Toxicity