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Simultaneous targeting of NPC1 and VDAC1 by itraconazole leads to synergistic inhibition of MTOR signaling and angiogenesis Journal article
Head S.A., Shi W.Q., Yang E.J., Nacev B.A., Hong S.Y., Pasunooti K.K., Li R.-J., Shim J.S., Liu J.O.. Simultaneous targeting of NPC1 and VDAC1 by itraconazole leads to synergistic inhibition of MTOR signaling and angiogenesis[J]. ACS Chemical Biology, 2017, 12(1), 174.
Authors:  Head S.A.;  Shi W.Q.;  Yang E.J.;  Nacev B.A.;  Hong S.Y.; et al.
Favorite | TC[WOS]:65 TC[Scopus]:66 | Submit date：2018/10/30
Antidepressant indatraline induces autophagy and inhibits restenosis via suppression of mTOR/S6 kinase signaling pathway Journal article
Cho Y.S., Yen C.-N., Shim J.S., Kang D.H., Kang S.W., Liu J.O., Kwon H.J.. Antidepressant indatraline induces autophagy and inhibits restenosis via suppression of mTOR/S6 kinase signaling pathway[J]. Scientific Reports, 2016, 6.
Authors:  Cho Y.S.;  Yen C.-N.;  Shim J.S.;  Kang D.H.;  Kang S.W.; et al.
Favorite | TC[WOS]:28 TC[Scopus]:30 | Submit date：2019/01/15
Divergence of antiangiogenic activity and hepatotoxicity of different stereoisomers of itraconazole Journal article
Shim J.S., Li R.-J., Bumpus N.N., Head S.A., Pasunooti K.K., Yang E.J., Lv J., Shi W., Liu J.O.. Divergence of antiangiogenic activity and hepatotoxicity of different stereoisomers of itraconazole[J]. Clinical Cancer Research, 2016, 22(11), 2709-2720.
Authors:  Shim J.S.;  Li R.-J.;  Bumpus N.N.;  Head S.A.;  Pasunooti K.K.; et al.
Favorite | TC[WOS]:12 TC[Scopus]:12 | Submit date：2019/01/15
Inhibition of angiogenesis by selective estrogen receptor modulators through blockade of cholesterol trafficking rather than estrogen receptor antagonism Journal article
Shim J.S., Li R.-J., Lv J., Head S.A., Yang E.J., Liu J.O.. Inhibition of angiogenesis by selective estrogen receptor modulators through blockade of cholesterol trafficking rather than estrogen receptor antagonism[J]. Cancer Letters, 2015, 362(1), 106-115.
Authors:  Shim J.S.;  Li R.-J.;  Lv J.;  Head S.A.;  Yang E.J.; et al.
Favorite | TC[WOS]:23 TC[Scopus]:25 | Submit date：2019/01/15
Angiogenesis  Cholesterol Trafficking  Selective Estrogen Receptor Modulator  Tamoxifen  
Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells Journal article
Head S.A., Shi W., Zhao L., Gorshkov K., Pasunooti K., Chen Y., Deng Z., Li R.-J., Shim J.S., Tan W., Hartung T., Zhang J., Zhao Y., Colombini M., Liu J.O.. Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells[J]. Proceedings of the National Academy of Sciences of the United States of America, 2015, 112(52), E7276.
Authors:  Head S.A.;  Shi W.;  Zhao L.;  Gorshkov K.;  Pasunooti K.; et al.
Favorite | TC[WOS]:83 TC[Scopus]:88 | Submit date：2018/10/30
Angiogenesis  Itraconazole  Metabolism  Mitochondria  Vdac1  
First quantitative high-throughput screen in zebrafish identifies novel pathways for increasing pancreatic β-cell mass Journal article
Wang G., Rajpurohit S.K., Delaspre F., Walker S.L., White D.T., Ceasrine A., Kuruvilla R., Li R.-J., Shim J.S., Liu J.O., Parsons M.J., Mumm J.S.. First quantitative high-throughput screen in zebrafish identifies novel pathways for increasing pancreatic β-cell mass[J]. eLife, 2015, 4(2015-07-01).
Authors:  Wang G.;  Rajpurohit S.K.;  Delaspre F.;  Walker S.L.;  White D.T.; et al.
Favorite | TC[WOS]:54 TC[Scopus]:82 | Submit date：2018/10/30
Identification of an old antibiotic clofoctol as a novel activator of unfolded protein response pathways and an inhibitor of prostate cancer Journal article
Wang M., Shim J.S., Li R.-J., Dang Y., He Q., Das M., Liu J.O.. Identification of an old antibiotic clofoctol as a novel activator of unfolded protein response pathways and an inhibitor of prostate cancer[J]. British Journal of Pharmacology, 2014, 171(19), 4478-4489.
Authors:  Wang M.;  Shim J.S.;  Li R.-J.;  Dang Y.;  He Q.; et al.
Favorite | TC[WOS]:26 TC[Scopus]:28 | Submit date：2019/01/15
Personalized chemotherapy profiling using cancer cell lines from selectable mice Journal article
Kamiyama H., Rauenzahn S., Shim J.S., Karikari C.A., Feldmann G., Hua L., Kamiyama M., Schuler F.W., Lin M.-T., Beaty R.M., Karanam B., Liang H., Mullendore M.E., Mo G., Hidalgo M., Jaffee E., Hruban R.H., Jinnah H.A., Roden R.B.S., Jimeno A., Liu J.O., Maitra A., Eshleman J.R.. Personalized chemotherapy profiling using cancer cell lines from selectable mice[J]. Clinical Cancer Research, 2013, 19(5), 1139-1146.
Authors:  Kamiyama H.;  Rauenzahn S.;  Shim J.S.;  Karikari C.A.;  Feldmann G.; et al.
Favorite | TC[WOS]:22 TC[Scopus]:23 | Submit date：2019/01/15
Selective inhibition of HER2-positive breast cancer cells by the HIV protease inhibitor nelfinavir Journal article
Shim J.S., Rao R., Beebe K., Neckers L., Han I., Nahta R., Liu J.O.. Selective inhibition of HER2-positive breast cancer cells by the HIV protease inhibitor nelfinavir[J]. Journal of the National Cancer Institute, 2012, 104(20), 1576-1590.
Authors:  Shim J.S.;  Rao R.;  Beebe K.;  Neckers L.;  Han I.; et al.
Favorite | TC[WOS]:71 TC[Scopus]:76 | Submit date：2019/01/15
Chemical screen identifies FDA-approved drugs and target pathways that induce precocious pancreatic endocrine differentiation Journal article
Rovira M., Huang W., Yusuff S., Shim J.S., Ferrante A.A., Liu J.O., Parsons M.J.. Chemical screen identifies FDA-approved drugs and target pathways that induce precocious pancreatic endocrine differentiation[J]. Proceedings of the National Academy of Sciences of the United States of America, 2011, 108(48), 19264-19269.
Authors:  Rovira M.;  Huang W.;  Yusuff S.;  Shim J.S.;  Ferrante A.A.; et al.
Favorite | TC[WOS]:75 TC[Scopus]:79 | Submit date：2019/01/15
Development  Embryogenesis  Notch-signaling  Progenitor