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Small molecule α-methylene-γ-butyrolactone, an evolutionarily conserved moiety in sesquiterpene lactones, ameliorates arthritic phenotype via interference DNA binding activity of NF-κB Journal article
Linghu, Kegang, Cui, Wenqing, Li, Taiqin, Tuo, Yueting, Wang, Dasong, Pan, Huiqi, Zhang, Tian, Lin, Ligen, Yu, Hua, Hu, Xiaoxia, Li, Haiyang, Shen, Xiangchun. Small molecule α-methylene-γ-butyrolactone, an evolutionarily conserved moiety in sesquiterpene lactones, ameliorates arthritic phenotype via interference DNA binding activity of NF-κB[J]. Acta Pharmaceutica Sinica B, 2024, 14(8), 3561-3575.
Authors:  Linghu, Kegang;  Cui, Wenqing;  Li, Taiqin;  Tuo, Yueting;  Wang, Dasong; et al.
Favorite | TC[WOS]:3 TC[Scopus]:4  IF:14.7/14.1 | Submit date:2024/05/16
A-methylene-g-  Butyrolactone  Rheumatoid Arthritis  Nf-kb P65  Synovial  Microenvironment  Sesquiterpene Lactones  
Novel Compound-Target Interactions Prediction for the Herbal Formula Hua-Yu-Qiang-Shen-Tong-Bi-Fang Journal article
Zihao Wang, Hui-Heng Lin, Kegang Linghu, Run-Yue Huang, Guangyao Li, Huali Zuo, Hua Yu, Ging Chan, Yuanjia Hu. Novel Compound-Target Interactions Prediction for the Herbal Formula Hua-Yu-Qiang-Shen-Tong-Bi-Fang[J]. CHEMICAL & PHARMACEUTICAL BULLETIN, 2019, 67(8), 778-785.
Authors:  Zihao Wang;  Hui-Heng Lin;  Kegang Linghu;  Run-Yue Huang;  Guangyao Li; et al.
Favorite | TC[WOS]:7 TC[Scopus]:8  IF:1.5/1.7 | Submit date:2020/01/06
Herbal Formula  Hua-yu-qiang-shen-tong-bi-fang  Natural Product  In-silico Target Identification  Network Link Prediction  
Flaxseed extract induces apoptosis in human breast cancer MCF-7 cells Journal article
Tingyan Hu, Kegang Linghu, Siqi Huang, Maurizio Battino, Milen I. Georgiev, Gokhan Zengin, Defang Li, Yun Deng, Y.T. Wang, Hui Cao. Flaxseed extract induces apoptosis in human breast cancer MCF-7 cells[J]. Food and Chemical Toxicology, 2019, 127, 188-196.
Authors:  Tingyan Hu;  Kegang Linghu;  Siqi Huang;  Maurizio Battino;  Milen I. Georgiev; et al.
Favorite | TC[WOS]:18 TC[Scopus]:21  IF:3.9/4.5 | Submit date:2020/03/27
Flaxseed  Mcf-7 cells  Apoptosis  Ros  Mitochondrial Membrane Potential  Dietary Supplement  
Siegesbeckia pubescens Makino inhibits Pam(3)CSK(4)-induced inflammation in RAW 264.7 macrophages through suppressing TLR1/TLR2-mediated NF-kappa B activation Journal article
Sang, Wei, Zhong, Zhangfeng, Linghu, Kegang, Xiong, Wei, Tse, Anfernee Kai Wing, Cheang, Wai San, Yu, Hua, Wang, Yitao. Siegesbeckia pubescens Makino inhibits Pam(3)CSK(4)-induced inflammation in RAW 264.7 macrophages through suppressing TLR1/TLR2-mediated NF-kappa B activation[J]. CHINESE MEDICINE, 2018, 13.
Authors:  Sang, Wei;  Zhong, Zhangfeng;  Linghu, Kegang;  Xiong, Wei;  Tse, Anfernee Kai Wing; et al.
Favorite | TC[WOS]:33 TC[Scopus]:33  IF:5.3/5.5 | Submit date:2018/10/30
Siegesbeckia Pubescens Makino  Pam(3)Csk(4)  Inflammation  Toll-like Receptor 1/2  Nf-kappa b