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Tulipalin A suppressed the pro-inflammatory polarization of M1 macrophage and mitigated the acute lung injury in mice via interference DNA binding activity of NF-κB Journal article
Linghu, Ke Gang, Tuo, Yue Ting, Cui, Wen Qing, Li, Tai Qin, Wang, Da Song, Zhang, Ya Ya, Zhang, Jian, Zhang, Tian, Wang, Yu E., Yu, Hua, Shen, Xiang Chun, Li, Hai Yang. Tulipalin A suppressed the pro-inflammatory polarization of M1 macrophage and mitigated the acute lung injury in mice via interference DNA binding activity of NF-κB[J]. European Journal of Pharmacology, 2024, 984, 177034.
Authors:  Linghu, Ke Gang;  Tuo, Yue Ting;  Cui, Wen Qing;  Li, Tai Qin;  Wang, Da Song; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:4.2/4.3 | Submit date：2024/11/05
Tulipalin a  Acute Lung Injury  M1 Polarization  Macrophage  Dna Binding Activity  Nf-κb  
Ganweikang extract protects hepatocytes from oxidative injury by activating Nrf2/HO-1 and MAPKs pathways Journal article
Xiao Linxuan, Zhao Mingming, Linghu Ke-Gang, Wu Guoping, Zhang Tian, Chen Chengyu, Guan Jianli, Cao Zhiming, HU YUANJIA, Yu Hua. Ganweikang extract protects hepatocytes from oxidative injury by activating Nrf2/HO-1 and MAPKs pathways[J]. Fitoterapia, 2024, 178, 106146.
Authors:  Xiao Linxuan;  Zhao Mingming;  Linghu Ke-Gang;  Wu Guoping;  Zhang Tian; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:2.5/2.7 | Submit date：2024/08/29
Acute Hepatic Injury  Ganweikang  Hepato-protection  Mapks  Nrf2/ho-1  
Small molecule deoxynyboquinone triggers alkylation and ubiquitination of Keap1 at Cys489 on Kelch domain for Nrf2 activation and inflammatory therapy Journal article
Linghu, Ke-Gang, Zhang, Tian, Zhang, Guang-Tao, Lv, Peng, Zhang, Wenjun, Zhao, Guanding, Xiong, Shihong, Zhao, Mingming, Chen, Meiwan, HU YUANJIA, Zhang, Changsheng, Yu, Hua. Small molecule deoxynyboquinone triggers alkylation and ubiquitination of Keap1 at Cys489 on Kelch domain for Nrf2 activation and inflammatory therapy[J]. Journal of Pharmaceutical Analysis, 2024, 14(3), 401-415.
Authors:  Linghu, Ke-Gang;  Zhang, Tian;  Zhang, Guang-Tao;  Lv, Peng;  Zhang, Wenjun; et al.
Favorite | TC[WOS]:6 TC[Scopus]:9  IF:6.1/6.8 | Submit date：2024/01/02
Deoxynyboquinone  Anti-inflammation  Target  Keap1/nrf2  Alkylation  Ubiquitination  
TRPM2 as a conserved gatekeeper determines the vulnerability of DA neurons by mediating ROS sensing and calcium dyshomeostasis Journal article
Ye, Peiwu, Fang, Qiuyuan, Hu, Xupang, Zou, Wenjuan, Huang, Miaodan, Ke, Minjing, Li, Yunhao, Liu, Min, Cai, Xiaobo, Zhang, Congyi, Hua, Ning, Al-Sheikh, Umar, Liu, Xingyu, Yu, Peilin, Jiang, Peiran, Pan, Ping Yue, Luo, Jianhong, Jiang, Lin Hua, Xu, Suhong, Fang, Evandro F., Su, Huanxing, Kang, Lijun, Yang, Wei. TRPM2 as a conserved gatekeeper determines the vulnerability of DA neurons by mediating ROS sensing and calcium dyshomeostasis[J]. Progress in Neurobiology, 2023, 231, 102530.
Authors:  Ye, Peiwu;  Fang, Qiuyuan;  Hu, Xupang;  Zou, Wenjuan;  Huang, Miaodan; et al.
Favorite | TC[WOS]:1 TC[Scopus]:1  IF:6.7/8.7 | Submit date：2024/01/02
Dopaminergic Neurons  Parkinson's Disease  Trpm2  Vulnerability  
A mannitol-modified emodin nano-drug restores the intestinal barrier function and alleviates inflammation in a mouse model of DSS-induced ulcerative colitis Journal article
Xu, Yin Yue, Zhu, Min, Wu, Jiang, Luo, Long Biao, Dong, Si jing, Zhang, Meng Gai, Liu, Xue, Wang, Ke, Luo, Hua, Jing, Wang Hui, Wang, Lin, Wang, Si Cen. A mannitol-modified emodin nano-drug restores the intestinal barrier function and alleviates inflammation in a mouse model of DSS-induced ulcerative colitis[J]. Chinese Medicine (United Kingdom), 2023, 18(1), 98.
Authors:  Xu, Yin Yue;  Zhu, Min;  Wu, Jiang;  Luo, Long Biao;  Dong, Si jing; et al.
Favorite | TC[WOS]:7 TC[Scopus]:8  IF:5.3/5.5 | Submit date：2023/09/21
Emodin  Intestinal Barrier  Nano Drug Delivery System  Ulcerative Colitis  
Expanding potential targets of herbal chemicals by node2vec based on herb–drug interactions Journal article
Dai-yan Zhang, Wen-qing Cui, Ling Hou, Jing Yang, Li-yang Lyu, Ze-yu Wang, Ke-Gang Linghu, Wen-bin He, Hua Yu, Yuan-jia Hu. Expanding potential targets of herbal chemicals by node2vec based on herb–drug interactions[J]. Chinese Medicine (United Kingdom), 2023, 18(1), 64.
Authors:  Dai-yan Zhang;  Wen-qing Cui;  Ling Hou;  Jing Yang;  Li-yang Lyu; et al.
Favorite | TC[WOS]:1 TC[Scopus]:2  IF:5.3/5.5 | Submit date：2023/08/03
Cardiovascular Disease  Herb–drug Interaction  Link Prediction  Node2vec  Traditional Medicine  
Leocarpinolide B Attenuates Collagen Type II-Induced Arthritis by Inhibiting DNA Binding Activity of NF-κB Journal article
Linghu, Ke Gang, Zhao, Guan Ding, Zhang, Dai Yan, Xiong, Shi Hang, Wu, Guo Ping, Shen, Li Yu, Cui, Wen Qing, Zhang, Tian, Hu, Yuan Jia, Guo, Bing, Shen, Xiang Chun, Yu, Hua. Leocarpinolide B Attenuates Collagen Type II-Induced Arthritis by Inhibiting DNA Binding Activity of NF-κB[J]. Molecules (Basel, Switzerland), 2023, 28(10), 4241.
Authors:  Linghu, Ke Gang;  Zhao, Guan Ding;  Zhang, Dai Yan;  Xiong, Shi Hang;  Wu, Guo Ping; et al.
Favorite | TC[WOS]:4 TC[Scopus]:4  IF:4.2/4.6 | Submit date：2023/06/05
Leocarpinolide b  Nf-κb P65  Rheumatoid Arthritis  Sesquiterpene Lactone  Synovitis  
Single-dose rAAV5-based vaccine provides long-term protective immunity against SARS-CoV-2 and its variants Journal article
Liao, Guochao, Lau, Hungyan, Liu, Zhongqiu, Li, Chinyu, Xu, Zeping, Qi, Xiaoxiao, Zhang, Yu, Feng, Qian, Li, Runze, Deng, Xinyu, Li, Yebo, Zhu, Qing, Zhu, Sisi, Zhou, Hua, Pan, Hudan, Fan, Xingxing, Li, Yongchao, Li, Dan, Chen, Liqing, Ke, Bixia, Cong, Zhe, Lv, Qi, Liu, Jiangning, Liang, Dan, Li, An’an, Hong, Wenshan, Bao, Linlin, Zhou, Feng, Gao, Hongbin, Liang, Shi, Huang, Bihong, Wu, Miaoli, Qin, Chuan, Ke, Changwen, Liu, Liang. Single-dose rAAV5-based vaccine provides long-term protective immunity against SARS-CoV-2 and its variants[J]. Virology Journal, 2022, 19(1).
Authors:  Liao, Guochao;  Lau, Hungyan;  Liu, Zhongqiu;  Li, Chinyu;  Xu, Zeping; et al.
Favorite | TC[WOS]:5 TC[Scopus]:5  IF:4.0/3.8 | Submit date：2023/01/30
Neutralizing Antibodies  Raav5  Sars-cov-2  Vaccine  Virus Challenge  
The “whole ingredients extract” of Astragali Radix improves the symptoms of dextran sulfate sodium-induced ulcerative colitis in mice through systemic immunomodulation Journal article
Linghu, Ke Gang, Ma, Qiushuo, Xiong, Shi Hang, Zhao, Mingming, Chen, Qiling, Xu, Wen, Chen, Meiwan, Zhang, Jian Ye, Hu, Yuanjia, Xu, Wei, Yu, Hua. The “whole ingredients extract” of Astragali Radix improves the symptoms of dextran sulfate sodium-induced ulcerative colitis in mice through systemic immunomodulation[J]. Chinese Medicine (United Kingdom), 2022, 17(1), 109.
Authors:  Linghu, Ke Gang;  Ma, Qiushuo;  Xiong, Shi Hang;  Zhao, Mingming;  Chen, Qiling; et al.
Favorite | TC[WOS]:3 TC[Scopus]:4  IF:5.3/5.5 | Submit date：2023/01/30
Astragali Radix  Whole Ingredients Extract  Immunomodulation  Ulcerative Colitis  
Nao Tan Qing ameliorates Alzheimer's disease-like pathology by regulating glycolipid metabolism and neuroinflammation: A network pharmacology analysis and biological validation Journal article
Qianqian Li, Caixia Jia, Hongxing Wu, Yajin Liao, Ke Yang, Shuoshuo Li, Jing Zhang, Jinlei Wang, Guo Li, Fangxia Guan, Elaine Lai-Han Leung, Zengqiang Yuang, Qian Hua, Rui-Yuan Pan. Nao Tan Qing ameliorates Alzheimer's disease-like pathology by regulating glycolipid metabolism and neuroinflammation: A network pharmacology analysis and biological validation[J]. PHARMACOLOGICAL RESEARCH, 2022, 185, 106489.
Authors:  Qianqian Li;  Caixia Jia;  Hongxing Wu;  Yajin Liao;  Ke Yang; et al.
Adobe PDF | Favorite | TC[WOS]:15 TC[Scopus]:15  IF:9.1/9.0 | Submit date：2022/12/01
Alzheimer's Disease  Systems Pharmacology  Nao Tan Qing  Traditional Chinese Medicine  Glycolipid Metabolism  Neuroinflammation