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A Mitochondria-Targeted Phenylbutyric Acid Prodrug Confers Drastically Improved Anticancer Activities Journal article
D. Huang, Q. Liu, M. Zhang, Y. Gao, Z. Cui, T. Li, D. Luo, B. Xu, C. Huang, J. Guo, K.Y. Tam, M. Zhang, S.L. Zhang, Y. He. A Mitochondria-Targeted Phenylbutyric Acid Prodrug Confers Drastically Improved Anticancer Activities[J]. JOURNAL OF MEDICINAL CHEMISTRY, 2022, 65(14), 9955-9973.
Authors:  D. Huang;  Q. Liu;  M. Zhang;  Y. Gao;  Z. Cui; et al.
Favorite | TC[WOS]:11 TC[Scopus]:11  IF:6.8/7.1 | Submit date：2022/08/28
Lung-cancer  Breast  Derivatives  Inhibitor  
Anti-neuroinflammatory effects of SLOH in Aβ-induced BV-2 microglial cells and 3xTg-AD mice involve the inhibition of GSK-3β Journal article
Wu X., Kosaraju J., Tam K.Y.. Anti-neuroinflammatory effects of SLOH in Aβ-induced BV-2 microglial cells and 3xTg-AD mice involve the inhibition of GSK-3β[J]. Neuroscience Letters, 2018, 687, 207-215.
Authors:  Wu X.;  Kosaraju J.;  Tam K.Y.
Favorite | TC[WOS]:9 TC[Scopus]:8 | Submit date：2018/12/18
3xtg-ad Mice  Bv-2 Cells  Gsk-3β  Neuroinflammation  Sloh  
Identification of Novel Pyruvate Dehydrogenase Kinase 1 (PDK1) Inhibitors by Kinase Activity-Based High-Throughput Screening for Anticancer Therapeutics Journal article
Zhang W., Hu X., Chakravarty H., Yang Z., Tam K.Y.. Identification of Novel Pyruvate Dehydrogenase Kinase 1 (PDK1) Inhibitors by Kinase Activity-Based High-Throughput Screening for Anticancer Therapeutics[J]. ACS Combinatorial Science, 2018, 20(11), 660-671.
Authors:  ; et al.
Favorite | TC[WOS]:12 TC[Scopus]:12 | Submit date：2018/12/18
Cancer  High-throughput Screening  Pyruvate Dehydrogenase Kinase 1  Small Molecule Inhibitors  Warburg Effect  
Identification of a Wells-Dawson polyoxometalatebased AP-2γ inhibitor with pro-apoptotic activity Journal article
Hu J., Tan S.K., Lim M.G.L., Chang S.H., Cui G., Liu S., Narasimhan K., New S.Y., Wang X., Chen C., Chakravarty H., Kolatkar P.R., Tam K.Y., Lu Q., Su X., Jauch R., Cheung E.. Identification of a Wells-Dawson polyoxometalatebased AP-2γ inhibitor with pro-apoptotic activity[J]. Biochemical Journal, 2018, 475(11), 1965-1977.
Authors:  Hu J.;  Tan S.K.;  Lim M.G.L.;  Chang S.H.;  Cui G.; et al.
Favorite | TC[WOS]:9 TC[Scopus]:10 | Submit date：2018/12/17
SLM, a novel carbazole-based fluorophore attenuates okadaic acid-induced tau hyperphosphorylation via down-regulating GSK-3β activity in SH-SY5Y cells Journal article
Wu X., Kosaraju J., Tam K.Y.. SLM, a novel carbazole-based fluorophore attenuates okadaic acid-induced tau hyperphosphorylation via down-regulating GSK-3β activity in SH-SY5Y cells[J]. European Journal of Pharmaceutical Sciences, 2017, 110, 101-108.
Authors:  Wu X.;  Kosaraju J.;  Tam K.Y.
Favorite | TC[WOS]:11 TC[Scopus]:10 | Submit date：2018/12/18
Alzheimer's Disease  Glycogen Synthase Kinase-3β  Okadaic Acid  Slm  Tau Hyperphosphorylation  
Geniposide improves insulin production and reduces apoptosis in high glucose-induced glucotoxic insulinoma cells Journal article
Guo L.X., Liu J.H., Zheng X.X., Yin Z.Y., Kosaraju J., Tam K.Y.. Geniposide improves insulin production and reduces apoptosis in high glucose-induced glucotoxic insulinoma cells[J]. European Journal of Pharmaceutical Sciences, 2017, 110, 70-76.
Authors:  Guo L.X.;  Liu J.H.;  Zheng X.X.;  Yin Z.Y.;  Kosaraju J.; et al.
Favorite | TC[WOS]:17 TC[Scopus]:22 | Submit date：2018/12/18
Apoptosis  Geniposide  Glucose-stimulated Insulin Secretion  Glucotoxicity  
Synthesis and biological evaluation of (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides as pyruvate dehydrogenase kinase 1 (PDK1) inhibitors to reduce the growth of cancer cells Journal article
Zhang S.-L., Zhang W., Yang Z., Hu X., Tam K.Y.. Synthesis and biological evaluation of (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides as pyruvate dehydrogenase kinase 1 (PDK1) inhibitors to reduce the growth of cancer cells[J]. European Journal of Pharmaceutical Sciences, 2017, 110, 87-92.
Authors:  Zhang S.-L.;  Zhang W.;  Yang Z.;  Hu X.;  Tam K.Y.
Favorite | TC[WOS]:7 TC[Scopus]:7 | Submit date：2018/12/18
Anti-proliferation  Binding Affinity  Pyruvate Dehydrogenase Complex  Pyruvate Dehydrogenase Kinase  
Neuroprotective Effect of SLM, a Novel Carbazole-Based Fluorophore, on SH-SY5Y Cell Model and 3xTg-AD Mouse Model of Alzheimer’s Disease Journal article
Wu X., Kosaraju J., Zhou W., Tam K.Y.. Neuroprotective Effect of SLM, a Novel Carbazole-Based Fluorophore, on SH-SY5Y Cell Model and 3xTg-AD Mouse Model of Alzheimer’s Disease[J]. ACS Chemical Neuroscience, 2017, 8(3), 676-685.
Authors:  Wu X.;  Kosaraju J.;  Zhou W.;  Tam K.Y.
Favorite | TC[WOS]:21 TC[Scopus]:22 | Submit date：2018/12/18
3xtg-ad  Aggregation  Alzheimer’s Disease  Amyloid β  Neuroprotection  Sh-sy5y  Slm  
Association of vancomycin with lipid vesicles Journal article
Hu X., Tam K.Y.. Association of vancomycin with lipid vesicles[J]. ADMET and DMPK, 2017, 5(3), 182-191.
Authors:  Hu X.;  Tam K.Y.
Favorite | TC[WOS]:2 TC[Scopus]:1 | Submit date：2018/12/18
Antibiotics  Binding  Liposome  Membrane  Phospholipids  
How Ethnic Minority Students Perceive Patterns in Chinese Characters: Knowledge of Character Components and Structures Book chapter
出自: CHINESE AS A SECOND LANGUAGE ASSESSMENT:SPRINGER-VERLAG SINGAPORE PTE LTD, 2017, 页码:91-113
Authors:  Elizabeth K.Y. Loh;  Loretta C.W. Tam;  Cally P.T. Lau;  Shing On Leung
Favorite | TC[WOS]:4 TC[Scopus]:4 | Submit date：2018/10/30
Chinese As a Second Language (Csl)  Ethnic Minority (Em) Students  Orthographic Awareness  Chinese Character Components  Learning Strategies