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TNFR2 antagonistic antibody induces the death of tumor infiltrating CD4+Foxp3+ regulatory T cells Journal article
He, Tianzhen, Chen, Yibo, Yang, De, Islam, Md Sahidul, Chou, Chon Kit, Liu, Jiarui, Faustman, Denise L., Oppenheim, Joost J., Chen, Xin*. TNFR2 antagonistic antibody induces the death of tumor infiltrating CD4+Foxp3+ regulatory T cells[J]. Cellular Oncology, 2022, 46(1), 167-177.
Authors:  He, Tianzhen;  Chen, Yibo;  Yang, De;  Islam, Md Sahidul;  Chou, Chon Kit; et al.
Favorite | TC[WOS]:7 TC[Scopus]:6  IF:4.9/5.2 | Submit date：2023/01/30
cd4+foxp3+ Regulatory t Cells (Tregs)  Cell Death  Lymphoma  Tnfr2  Tnfr2 Antagonistic Antibody  
A TNFR2 antibody by countering immunosuppression cooperates with HMGN1 and R848 immune stimulants to inhibit murine colon cancer Journal article
Jiang, Mengmeng, Liu, Jia, Yang, De, Tross, Debra, Li, Ping, Chen, Fengyang, Alam, Md Masud, Faustman, Denise L., Oppenheim, Joost J., Chen, Xin. A TNFR2 antibody by countering immunosuppression cooperates with HMGN1 and R848 immune stimulants to inhibit murine colon cancer[J]. International Immunopharmacology, 2021, 101, 108345.
Authors:  Jiang, Mengmeng;  Liu, Jia;  Yang, De;  Tross, Debra;  Li, Ping; et al.
Favorite | TC[WOS]:22 TC[Scopus]:22  IF:4.8/5.0 | Submit date：2021/12/08
Antitumor  cd4+foxp3+ Regulatory t Cells (Tregs)  Hmgn1 And R848  Immunotherapy  Tnfr2  
Inhibition of two-pore channels in antigen-presenting cells promotes the expansion of TNFR2-expressing CD4+Foxp3+ regulatory T cells Journal article
He,Tianzhen, Yang,De, Li,Xiao Qing, Jiang,Mengmeng, Islam,Md Sahidul, Chen,Shaokui, Chen,Yibo, Yang,Yang, Chou,Chon Kit, Trivett,Anna L., Oppenheim,Joost J., Chen,Xin*. Inhibition of two-pore channels in antigen-presenting cells promotes the expansion of TNFR2-expressing CD4+Foxp3+ regulatory T cells[J]. Science Advances, 2020, 6(40), eaba6584.
Authors:  He,Tianzhen;  Yang,De;  Li,Xiao Qing;  Jiang,Mengmeng;  Islam,Md Sahidul; et al.
Favorite | TC[WOS]:14 TC[Scopus]:15  IF:11.7/13.7 | Submit date：2021/03/01
Blockade of TNFR2 signaling enhances the immunotherapeutic effect of CpG ODN in a mouse model of colon cancer Journal article
Nie, Yingjie, He, Jiang, Shirota, Hidekazu, Trivett, Anna L., Yang, De, Klinman, Dennis M., Oppenheim, Joost J., Chen, Xin. Blockade of TNFR2 signaling enhances the immunotherapeutic effect of CpG ODN in a mouse model of colon cancer[J]. SCIENCE SIGNALING, 2018, 11(511).
Authors:  Nie, Yingjie;  He, Jiang;  Shirota, Hidekazu;  Trivett, Anna L.;  Yang, De; et al.
Favorite | TC[WOS]:53 TC[Scopus]:56  IF:6.7/7.2 | Submit date：2018/10/30
Development of a Curative Therapeutic Vaccine (TheraVac) for the Treatment of Large Established Tumors Journal article
Nie, Yingjie, Yang, De, Trivett, Anna, Han, Zhen, Xin, Haiyun, Chen, Xin, Oppenheim, Joost J.. Development of a Curative Therapeutic Vaccine (TheraVac) for the Treatment of Large Established Tumors[J]. SCIENTIFIC REPORTS, 2017, 7.
Authors:  Nie, Yingjie;  Yang, De;  Trivett, Anna;  Han, Zhen;  Xin, Haiyun; et al.
Favorite | TC[WOS]:29 TC[Scopus]:30  IF:3.8/4.3 | Submit date：2018/10/30
Targeting TNFR2, an immune checkpoint stimulator and oncoprotein, is a promising treatment for cancer Journal article
Chen, Xin, Oppenheim, Joost J.. Targeting TNFR2, an immune checkpoint stimulator and oncoprotein, is a promising treatment for cancer[J]. SCIENCE SIGNALING, 2017, 10(462).
Authors:  Chen, Xin;  Oppenheim, Joost J.
Favorite | TC[WOS]:60 TC[Scopus]:59  IF:6.7/7.2 | Submit date：2018/10/30
Therapy: Paradoxical effects of targeting TNF signalling in the treatment of autoimmunity Journal article
Xin Chen, Joost J Oppenheim. Therapy: Paradoxical effects of targeting TNF signalling in the treatment of autoimmunity[J]. Nature Reviews Rheumatology, 2016, 12(11), 625–626.
Authors:  Xin Chen;  Joost J Oppenheim
Favorite | TC[WOS]:18 TC[Scopus]:19  IF:29.4/30.6 | Submit date：2018/11/30
Autoimmunity  Rheumatoid Arthritis  t Cells  Tumour-necrosis Factors  
Th17 cells and Tregs: unlikely allies Journal article
Xin Chen, Joost J. Oppenheim. Th17 cells and Tregs: unlikely allies[J]. JOURNAL OF LEUKOCYTE BIOLOGY, 2014, 95(5), 723-731.
Authors:  Xin Chen;  Joost J. Oppenheim
Favorite | TC[WOS]:70 TC[Scopus]:85  IF:3.6/5.2 | Submit date：2019/01/14
Synergistic antitumor effects of a TGFβ inhibitor and cyclophosphamide Journal article
Xin Chen, Lalage M Wakefield, Joost J Oppenheim. Synergistic antitumor effects of a TGFβ inhibitor and cyclophosphamide[J]. ONCOIMMUNOLOGY, 2014, 3(4).
Authors:  Xin Chen;  Lalage M Wakefield;  Joost J Oppenheim
Favorite | TC[WOS]:7 TC[Scopus]:7 | Submit date：2019/01/14
Anti-tgfβ Antibody  Cyclophosphamide  Chemoimmunotherapy  
In vitro generated Th17 cells support the expansion and phenotypic stability of CD4+ Foxp3+ regulatory T cells in vivo Journal article
Qiong Zhou, Ya Hu, O.M. Zack Howard, Joost J. Oppenheim, Xin Chen. In vitro generated Th17 cells support the expansion and phenotypic stability of CD4+ Foxp3+ regulatory T cells in vivo[J]. CYTOKINE, 2014, 65(1), 56-64.
Authors:  Qiong Zhou;  Ya Hu;  O.M. Zack Howard;  Joost J. Oppenheim;  Xin Chen
Favorite | TC[WOS]:18 TC[Scopus]:18  IF:3.7/3.5 | Submit date：2019/01/14
Regulatory t Cell  Il-2  Tnf  Tnfr2  Th17