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Lycorine promotes IDH1 acetylation to induce mitochondrial dynamics imbalance in colorectal cancer cells Journal article
Fang-Fang Zhuo, Ling Li, Ting-Ting Liu, Xiao-Min Liang, Zhuo Yang, Yong-Zhe Zheng, Qian-Wei Luo, Jia-Hong Lu, Dan Liu, Ke-Wu Zeng, Peng-Fei Tu. Lycorine promotes IDH1 acetylation to induce mitochondrial dynamics imbalance in colorectal cancer cells[J]. Cancer Letters, 2023, 573, 216364.
Authors:  Fang-Fang Zhuo;  Ling Li;  Ting-Ting Liu;  Xiao-Min Liang;  Zhuo Yang; et al.
Favorite | TC[WOS]:7 TC[Scopus]:9  IF:9.1/8.3 | Submit date：2023/09/22
Colorectal Cancer  Isocitrate Dehydrogenase (Idh)  Lycorine  Mitochondrial Dynamics  Oxidative Stress  Sirtuin 1  
Corynoxine B targets at HMGB1/2 to enhance autophagy for α-synuclein clearance in fly and rodent models of Parkinson's disease Journal article
Qi Zhu, Juxian Song, Jia-Yue Chen, Zhenwei Yuan, Liangfeng Liu, Li-Ming Xie, Qiwen Liao, Richard D. Ye, Xiu Chen, Yepiao Yan, Jieqiong Tan, Chris Soon Heng Tan, Min Li, Jia-Hong Lu. Corynoxine B targets at HMGB1/2 to enhance autophagy for α-synuclein clearance in fly and rodent models of Parkinson's disease[J]. Acta Pharmaceutica Sinica B, 2023, 13(6), 2701-2714.
Authors:  Qi Zhu;  Juxian Song;  Jia-Yue Chen;  Zhenwei Yuan;  Liangfeng Liu; et al.
Favorite | TC[WOS]:7 TC[Scopus]:7  IF:14.7/14.1 | Submit date：2023/07/20
Autophagy  Corynoxine b  Hmgb1  Hmgb2  Neurodegenerative Disease  Parkinson's Disease  Pi3kc3  Α-synuclein  
Disease-Modifying Activity of Huperzine A on Alzheimer’s Disease: Evidence from Preclinical Studies on Rodent Models Journal article
Ye-Piao Yan, Jia-Yue Chen, Jia-Hong Lu. Disease-Modifying Activity of Huperzine A on Alzheimer’s Disease: Evidence from Preclinical Studies on Rodent Models[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23(23), 15238.
Authors:  Ye-Piao Yan;  Jia-Yue Chen;  Jia-Hong Lu
Favorite | TC[WOS]:12 TC[Scopus]:13  IF:4.9/5.6 | Submit date：2023/01/30
Huperzine a  Alzheimer’s Disease  Animal Studies  Preclinical Studies  Meta-analysis  Systematic Review  
Pharmacological modulation of autophagy for Alzheimer's disease therapy: Opportunities and obstacles Journal article
Zhiqiang Deng, Yu Dong , Xiaoting Zhou, Jia-Hong Lu, Zhenyu Yue. Pharmacological modulation of autophagy for Alzheimer's disease therapy: Opportunities and obstacles[J]. Acta Pharmaceutica Sinica B, 2022, 12(4), 1688-1706.
Authors:  Zhiqiang Deng;  Yu Dong ;  Xiaoting Zhou;  Jia-Hong Lu;  Zhenyu Yue
Favorite | TC[WOS]:16 TC[Scopus]:17  IF:14.7/14.1 | Submit date：2022/05/13
Alzheimer's Disease  Autophagy  Autophagy Modulators  Genetic Modulation  Lc3-associated Phagocytosis  Microglial Autophagy  Neuroinflammation  Neuronal Autophagy  
Emerging roles of NRBF2/PI3KC3 axis in maintaining homeostasis of brain and guts Journal article
Ming-Yue Wu, Cui-Zan Cai, Chuanbin Yang, Zhenyu Yue, Ye Chen, ZhaoXiang Bian, Min Li, Jia-Hong Lu. Emerging roles of NRBF2/PI3KC3 axis in maintaining homeostasis of brain and guts[J]. Neural Regeneration Research, 2022, 17(2), 323-324.
Authors:  Ming-Yue Wu;  Cui-Zan Cai;  Chuanbin Yang;  Zhenyu Yue;  Ye Chen; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:5.9/5.2 | Submit date：2022/03/04
The effect and underlying mechanisms of garlic extract against cognitive impairment and Alzheimer's disease: A systematic review and meta-analysis of experimental animal studies Journal article
Jing-Fang Luo, Yu Dong, Jia-Yue Chen, Jia-Hong Lu. The effect and underlying mechanisms of garlic extract against cognitive impairment and Alzheimer's disease: A systematic review and meta-analysis of experimental animal studies[J]. JOURNAL OF ETHNOPHARMACOLOG, 2021, 280, 114423.
Authors:  Jing-Fang Luo;  Yu Dong;  Jia-Yue Chen;  Jia-Hong Lu
Favorite | TC[WOS]:15 TC[Scopus]:16  IF:4.8/4.8 | Submit date：2021/12/08
Garlic Extract  Alzheimer’s Disease  Neurodegenerative Disorders  Animal Models  Neuroprotective Effects  
Natural alkaloid compounds as inhibitors for alpha-synuclein seeded fibril formation and toxicity Journal article
Simona S. Ghanem, Hend S. Fayed, Qi Zhu, Jia Hong Lu, Nishant N. Vaikath, Janarthanan Ponraj, Said Mansour, Omar M.A. El-Agnaf. Natural alkaloid compounds as inhibitors for alpha-synuclein seeded fibril formation and toxicity[J]. Molecules, 2021, 26(12).
Authors:  Simona S. Ghanem;  Hend S. Fayed;  Qi Zhu;  Jia Hong Lu;  Nishant N. Vaikath; et al.
Favorite | TC[WOS]:21 TC[Scopus]:21  IF:4.2/4.6 | Submit date：2021/12/08
Parkinson’s Disease  Seeded Fibril Formation  Α-synuclein  
A small molecule transcription factor EB activator ameliorates beta-amyloid precursor protein and Tau pathology in Alzheimer's disease models Journal article
Ju-Xian Song, Sandeep Malampati, Yu Zeng, Siva Sundara Kumar Durairajan, Chuan-Bin Yang, Benjamin Chun-Kit Tong, Ashok Iyaswamy, Wen-Bin Shang, Sreenivasmurthy,Sravan Gopalkrishnashetty, Zhou Zhu, King-Ho Cheung, Jia-Hong Lu, Chunzhi Tang, Nenggui Xu, Min Li. A small molecule transcription factor EB activator ameliorates beta-amyloid precursor protein and Tau pathology in Alzheimer's disease models[J]. AGING CELL, 2020, 19(2).
Authors:  Ju-Xian Song;  Sandeep Malampati;  Yu Zeng;  Siva Sundara Kumar Durairajan;  Chuan-Bin Yang; et al.
Favorite | TC[WOS]:104 TC[Scopus]:113  IF:8.0/9.7 | Submit date：2021/03/02
Alzheimer's Disease  Beta-amyloid  Curcumin Analog C1  Mapt/tau  Tfeb  
Hydroxyurea Facilitates Manifestation of Disease Relevant Phenotypes in Patients-Derived IPSCs-Based Modeling of Late-Onset Parkinson’s Disease Journal article
Yuan Tan, Minjing Ke, Zhijian Huang, Cheong-Meng Chong, Xiaotong Cen, Jia-Hong Lu, Xiaoli Yao, Dajiang Qin, Huanxing Su. Hydroxyurea Facilitates Manifestation of Disease Relevant Phenotypes in Patients-Derived IPSCs-Based Modeling of Late-Onset Parkinson’s Disease[J]. Aging and Disease, 2019, 10(5), 1037-1048.
Authors:  Yuan Tan;  Minjing Ke;  Zhijian Huang;  Cheong-Meng Chong;  Xiaotong Cen; et al.
Favorite | TC[WOS]:8 TC[Scopus]:8  IF:7.0/7.1 | Submit date：2020/04/08
Disease Phenotypes  Er Stress  Induced Pluripotentstem Cells  Parkinson’s Disease  Hydroxyurea  
Canthin-6-One Accelerates Alpha-Synuclein Degradation by Enhancing UPS Activity: Drug Target Identification by CRISPR-Cas9 Whole Genome-Wide Screening Technology Journal article
Ning-Ning Yuan, Cui-Zan Cai, Ming-Yue Wu, Qi Zhu, HuanXing Su, Min Li, JiaoYan Ren, Jie-Qiong Tan, Jia-Hong Lu. Canthin-6-One Accelerates Alpha-Synuclein Degradation by Enhancing UPS Activity: Drug Target Identification by CRISPR-Cas9 Whole Genome-Wide Screening Technology[J]. FRONTIERS IN PHARMACOLOGY, 2019, 10.
Authors:  Ning-Ning Yuan;  Cui-Zan Cai;  Ming-Yue Wu;  Qi Zhu;  HuanXing Su; et al.
Favorite | TC[WOS]:17 TC[Scopus]:20  IF:4.4/5.0 | Submit date：2020/04/14
Canthin-6-one  Parkinson’s Disease  Alpha-synuclein  Ubiquitin-proteasome-system  Crispr/cas9  Rpn2/psmd1  Pka