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Astemizole inhibits mTOR signaling and angiogenesis by blocking cholesterol trafficking Journal article
Lyu,Junfang, Yang,Eun Ju, Head,Sarah A., Ai,Nana, Zhang,Baoyuan, Wu,Changjie, Li,Ruo Jing, Liu,Yifan, Chakravarty,Harapriya, Zhang,Shaolin, Tam,Kin Yip, Dang,Yongjun, Kwon,Ho Jeong, Ge,Wei, Liu,Jun O., Shim,Joong Sup. Astemizole inhibits mTOR signaling and angiogenesis by blocking cholesterol trafficking[J]. International Journal of Biological Sciences, 2018, 14(10), 1175-1185.
Authors:  Lyu,Junfang;  Yang,Eun Ju;  Head,Sarah A.;  Ai,Nana;  Zhang,Baoyuan; et al.
Favorite | TC[WOS]:21 TC[Scopus]:22  IF:8.2/8.3 | Submit date：2021/03/02
Angiogenesis  Astemizole  Cholesterol Trafficking  Mtor  Npc1  
Astemizole Inhibits mTOR Signaling and Angiogenesis by Blocking Cholesterol Trafficking Journal article
Lyu, Junfang, Yang, Eun Ju, Head, Sarah A., Ai, Nana, Zhang, Baoyuan, Wu, Changjie, Li, Ruo-Jing, Liu, Yifan, Chakravarty, Harapriya, Zhang, Shaolin, Tam, Kin Yip, Dang, Yongjun, Kwon, Ho Jeong, Gel, Wei, Liu, Jun O., Shim, Joong Sup. Astemizole Inhibits mTOR Signaling and Angiogenesis by Blocking Cholesterol Trafficking[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2018, 14(10), 1175-1185.
Authors:  Lyu, Junfang;  Yang, Eun Ju;  Head, Sarah A.;  Ai, Nana;  Zhang, Baoyuan; et al.
Favorite | TC[WOS]:21 TC[Scopus]:22  IF:8.2/8.3 | Submit date：2018/10/30
Cholesterol Trafficking  Angiogenesis  Astemizole  Npc1  Mtor  
Pharmacological blockade of cholesterol trafficking by cepharanthine in endothelial cells suppresses angiogenesis and tumor growth Journal article
Lyu, Junfang, Yang, Eun Ju, Head, Sarah A., Ai, Nana, Zhang, Baoyuan, Wu, Changjie, Li, Ruo-Jing, Liu, Yifan, Yang, Chen, Dang, Yongjun, Kwon, Ho Jeong, Ge, Wei, Liu, Jun O., Shim, Joong Sup. Pharmacological blockade of cholesterol trafficking by cepharanthine in endothelial cells suppresses angiogenesis and tumor growth[J]. CANCER LETTERS, 2017, 409, 91-103.
Authors:  Lyu, Junfang;  Yang, Eun Ju;  Head, Sarah A.;  Ai, Nana;  Zhang, Baoyuan; et al.
Favorite | TC[WOS]:56 TC[Scopus]:59  IF:9.1/8.3 | Submit date：2018/10/30
Cholesterol Trafficking  Angiogenesis  Tumor  Lysosome  Cepharanthine  
Simultaneous Targeting of NPC1 and VDAC1 by Itraconazole Leads to Synergistic Inhibition of mTOR Signaling and Angiogenesis Journal article
Head, Sarah A., Shi, Wei Q., Yang, Eun Ju, Nacev, Benjamin A., Hong, Sam Y., Pasunooti, Kalyan K., Li, Ruo-Jing, Shim, Joong Sup, Liu, Jun O.. Simultaneous Targeting of NPC1 and VDAC1 by Itraconazole Leads to Synergistic Inhibition of mTOR Signaling and Angiogenesis[J]. ACS CHEMICAL BIOLOGY, 2017, 12(1), 174-182.
Authors:  Head, Sarah A.;  Shi, Wei Q.;  Yang, Eun Ju;  Nacev, Benjamin A.;  Hong, Sam Y.; et al.
Favorite | TC[WOS]:65 TC[Scopus]:66  IF:3.5/3.9 | Submit date：2018/10/30
Divergence of anti-angiogenic activity and hepatotoxicity of different stereoisomers of itraconazole Journal article
Joong Sup Shim, Ruo-Jing Li, Namandje N. Bumpus, Sarah A. Head, Kalyan Kumar, Eun Ju Yang, Junfang Lv, Wei Shi, Jun O. Liu. Divergence of anti-angiogenic activity and hepatotoxicity of different stereoisomers of itraconazole[J]. Clinical Cancer Research, 2016, 22(11), 2709-2720.
Authors:  Joong Sup Shim;  Ruo-Jing Li;  Namandje N. Bumpus;  Sarah A. Head;  Kalyan Kumar; et al.
Favorite | TC[WOS]:12 TC[Scopus]:12  IF:10.0/11.1 | Submit date：2019/01/24
Itraconazole  Stereoisomers  Drug Repositioning  Angiogenesis  Hepatotoxicity  
The antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells Journal article
Sarah A. Head, Wei Shi, Liang Zhao, Kirill Gorshkov, Kalyan Pasunooti, Yue Chen, Zhiyou Deng, Ruo-jing Li, Joong Sup Shim, Wenzhi Tan, Thomas Hartung, Jin Zhang, Yingming Zhao, Marco Colombini, Jun O. Liu. The antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112(52), E7276-E7285.
Authors:  Sarah A. Head;  Wei Shi;  Liang Zhao;  Kirill Gorshkov;  Kalyan Pasunooti; et al.
Favorite | TC[WOS]:83 TC[Scopus]:88  IF:9.4/10.8 | Submit date：2019/01/24
Angiogenesis  Mitochondria  Metabolism  Itraconazole  Vdac1