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A new invertebrate NPY-like polypeptide, ZoaNPY, from the Zoanthus sociatus, as a novel ligand of human NPY Y2 receptor rescues vascular insufficiency via PLC/PKC and Src- FAK-dependent signaling pathways Journal article
Chen, Qian, Xu, Nan, Zhao, Chen, He, Yulin, Kam, Sandy Hio Tong, Wu, Xue, Huang, Pan, Yang, Min, Wong, Clarence Tsun Ting, Radis-Baptista, Gandhi, Tang, Benqin, Fan, Guangyi, Gong, Guiyi, Lee, Simon Ming Yuen. A new invertebrate NPY-like polypeptide, ZoaNPY, from the Zoanthus sociatus, as a novel ligand of human NPY Y2 receptor rescues vascular insufficiency via PLC/PKC and Src- FAK-dependent signaling pathways[J]. Pharmacological Research, 2024, 203, 107173.
Authors:  Chen, Qian;  Xu, Nan;  Zhao, Chen;  He, Yulin;  Kam, Sandy Hio Tong; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:9.1/9.0 | Submit date：2024/05/16
Angiogenesis  Cnidarian  Invertebrate Neuropeptide y  Npy Y2r  Transcriptome  
6-benzylaminopurine causes endothelial dysfunctions to human umbilical vein endothelial cells and exacerbates atorvastatin-induced cerebral hemorrhage in zebrafish Journal article
Gong, Guiyi, Kam, Hiotong, Bai, Yubin, Cheang, Wai San, Wu, Shuilong, Cheng, Xiaoning, Giesy, John P., Lee, Simon Ming-yuen. 6-benzylaminopurine causes endothelial dysfunctions to human umbilical vein endothelial cells and exacerbates atorvastatin-induced cerebral hemorrhage in zebrafish[J]. Environmental Toxicology, 2023, 39(3), 1258-1268.
Authors:  Gong, Guiyi;  Kam, Hiotong;  Bai, Yubin;  Cheang, Wai San;  Wu, Shuilong; et al.
Favorite | TC[WOS]:1 TC[Scopus]:1  IF:4.4/4.2 | Submit date：2023/11/07
6-benzylaminopurine  Huvecs  Mapk Pathway  Cerebral Hemorrhage  Endothelial Toxicity  
6-Benzylaminopurine causes lipid dyshomeostasis via disruption of glycerophospholipid metabolism in zebrafish Journal article
Gong, Guiyi, Kam, Hiotong, Bai, Yubin, Zhao, Hongxia, Giesy, John P., Lee, Simon Ming yuen. 6-Benzylaminopurine causes lipid dyshomeostasis via disruption of glycerophospholipid metabolism in zebrafish[J]. Science of the Total Environment, 2023, 878, 163194.
Authors:  Gong, Guiyi;  Kam, Hiotong;  Bai, Yubin;  Zhao, Hongxia;  Giesy, John P.; et al.
Favorite | TC[WOS]:12 TC[Scopus]:12  IF:8.2/8.6 | Submit date：2023/07/20
Agriculture  Asia  Glycerophospholipid Metabolism  Lysophosphatidylcholine  Metabolome  Transcriptome  
Role of endocrine disruption in toxicity of 6-benzylaminopurine (6-BA) to early-life stages of Zebrafish Journal article
Gong, Guiyi, Kam, Hiotong, Chen, Hanbin, Chen, Yan, Cheang, Wai san, Giesy, John P., Zhou, Qiaohong, Lee, Simon Ming yuen. Role of endocrine disruption in toxicity of 6-benzylaminopurine (6-BA) to early-life stages of Zebrafish[J]. Ecotoxicology and Environmental Safety, 2022, 232, 113287.
Authors:  Gong, Guiyi;  Kam, Hiotong;  Chen, Hanbin;  Chen, Yan;  Cheang, Wai san; et al.
Favorite | TC[WOS]:7 TC[Scopus]:6  IF:6.2/6.3 | Submit date：2022/03/28
Cyp19a  Endocrine Disruptors  Estrogenic  Neurogenesis  Plant Growth Regulator  
Toxic Peptide From Palythoa caribaeorum Acting on the TRPV1 Channel Prevents Pentylenetetrazol-Induced Epilepsy in Zebrafish Larvae Journal article
Wang, Xiufen, Liao, Qiwen, Chen, Hanbin, Gong, Guiyi, Siu, Shirley Weng In, Chen, Qian, Kam, Hiotong, Ung, Carolina Oi Lam, Cheung, Kwok Kuen, Rádis-Baptista, Gandhi, Wong, Clarence Tsun Ting, Lee, Simon Ming Yuen. Toxic Peptide From Palythoa caribaeorum Acting on the TRPV1 Channel Prevents Pentylenetetrazol-Induced Epilepsy in Zebrafish Larvae[J]. Frontiers in Pharmacology, 2021, 12.
Authors:  Wang, Xiufen;  Liao, Qiwen;  Chen, Hanbin;  Gong, Guiyi;  Siu, Shirley Weng In; et al.
Favorite | TC[WOS]:3 TC[Scopus]:2  IF:4.4/5.0 | Submit date：2022/01/14
Anti-epilepsy  Pcactx Peptide  Transcriptomics Analysis  Trpv1 Channel  Zebrafish  Zoantharian  
Crocetin and Its Glycoside Crocin, Two Bioactive Constituents From Crocus sativus L. (Saffron), Differentially Inhibit Angiogenesis by Inhibiting Endothelial Cytoskeleton Organization and Cell Migration Through VEGFR2/SRC/FAK and VEGFR2/MEK/ERK Signaling Pathways Journal article
Zhao, Chen, Kam, Hio Tong, Chen, Yan, Gong, Guiyi, Hoi, Maggie Pui Man, Skalicka-Woźniak, Krystyna, Dias, Alberto Carlos Pires, Lee, Simon Ming Yuen. Crocetin and Its Glycoside Crocin, Two Bioactive Constituents From Crocus sativus L. (Saffron), Differentially Inhibit Angiogenesis by Inhibiting Endothelial Cytoskeleton Organization and Cell Migration Through VEGFR2/SRC/FAK and VEGFR2/MEK/ERK Signaling Pathways[J]. Frontiers in Pharmacology, 2021, 12, 675359.
Authors:  Zhao, Chen;  Kam, Hio Tong;  Chen, Yan;  Gong, Guiyi;  Hoi, Maggie Pui Man; et al.
Favorite | TC[WOS]:11 TC[Scopus]:13  IF:4.4/5.0 | Submit date：2021/12/07
Crocetin  Crocin  Angiogenesis  Vegf  Zebrafish  Huvec  
Forchlorfenuron (CPPU) causes disorganization of the cytoskeleton and dysfunction of human umbilical vein endothelial cells, and abnormal vascular development in zebrafish embryos Journal article
Gong, Guiyi, Kam, Hiotong, Tse, Yu chung, Giesy, John P., Seto, Sai wang, Lee, Simon Ming yuen. Forchlorfenuron (CPPU) causes disorganization of the cytoskeleton and dysfunction of human umbilical vein endothelial cells, and abnormal vascular development in zebrafish embryos[J]. Environmental Pollution, 2021, 271, 115791.
Authors:  Gong, Guiyi;  Kam, Hiotong;  Tse, Yu chung;  Giesy, John P.;  Seto, Sai wang; et al.
Favorite | TC[WOS]:12 TC[Scopus]:14  IF:7.6/8.3 | Submit date：2021/12/07
Blood Vessels  Crop Growth Promotor  Huvecs  Septin  Toxicity  
In Vivo Screening of Xanthones from Garcinia oligantha Identified Oliganthin H as a Novel Natural Inhibitor of Convulsions Journal article
Gong,Guiyi, Chen,Hanbin, Kam,Hiotong, Chan,Ging, Tang,Yue Xun, Wu,Man, Tan,Hongsheng, Tse,Yu Chung, Xu,Hong Xi, Lee,Simon Ming Yuen. In Vivo Screening of Xanthones from Garcinia oligantha Identified Oliganthin H as a Novel Natural Inhibitor of Convulsions[J]. Journal of Natural Products, 2020, 83(12), 3706-3716.
Authors:  Gong,Guiyi;  Chen,Hanbin;  Kam,Hiotong;  Chan,Ging;  Tang,Yue Xun; et al.
Favorite | TC[WOS]:14 TC[Scopus]:15  IF:3.3/3.9 | Submit date：2021/03/01
Cardiotoxicity of forchlorfenuron (CPPU) in zebrafish (Danio rerio) and H9c2 cardiomyocytes Journal article
Guiyi Gong, Hiotong Kam, Yuchung Tse, Simon Mingyuen Lee. Cardiotoxicity of forchlorfenuron (CPPU) in zebrafish (Danio rerio) and H9c2 cardiomyocytes[J]. CHEMOSPHERE, 2019, 235, 153-162.
Authors:  Guiyi Gong;  Hiotong Kam;  Yuchung Tse;  Simon Mingyuen Lee
Favorite | TC[WOS]:39 TC[Scopus]:41  IF:8.1/7.7 | Submit date：2020/01/15
Forchlorfenuron (Cppu)  Zebrafish  Cardiotoxicity  Hematopoietic Toxicity  H9c2 Cardiomyocytes  Cytoskeletons Destruction  
Combined transcriptomic and proteomic analysis reveals a diversity of venom-related and toxin-like peptides expressed in the mat anemone Zoanthus natalensis (Cnidaria, Hexacorallia) Journal article
Qiwen Liao, Guiyi Gong, Terence C. W. Poon, Irene L. Ang, Kate M. K. Lei, Shirley Weng In Siu, Clarence Tsun Ting Wong, Gandhi Rádis-Baptista, Simon Ming-Yuen Lee. Combined transcriptomic and proteomic analysis reveals a diversity of venom-related and toxin-like peptides expressed in the mat anemone Zoanthus natalensis (Cnidaria, Hexacorallia)[J]. ARCHIVES OF TOXICOLOGY, 2019, 93(6), 1745-1767.
Authors:  Qiwen Liao;  Guiyi Gong;  Terence C. W. Poon;  Irene L. Ang;  Kate M. K. Lei; et al.
Favorite | TC[WOS]:18 TC[Scopus]:18  IF:4.8/5.3 | Submit date：2020/01/16
Cnidaria  Neuroprotection  Proteomic  Transcriptomic  Venom-derived Peptide  Zoantharian