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N-terminal α-amino group modification of antibodies using a site-selective click chemistry method Journal article
Li D.-Z., Han B.-N., Wei R., Yao G.-Y., Chen Z., Liu J., Poon T.C.W., Su W., Zhu Z., Dimitrov D.S., Zhao Q.. N-terminal α-amino group modification of antibodies using a site-selective click chemistry method[J]. mAbs, 2018, 10(5), 712-719.
Authors:  Li D.-Z.;  Han B.-N.;  Wei R.;  Yao G.-Y.;  Chen Z.; et al.
Favorite | TC[WOS]:25 TC[Scopus]:26 | Submit date：2019/01/16
Antibody  Antibody Engineering  Antibody-drug Conjugate  Click Chemistry  Site-specific Modification  
N-terminal α-amino group modification of antibodies using a site-selective click chemistry method Journal article
Li, D., Han, B., Wei, R., Yao, G., Chen, Z., Liu, J., Poon, C. W., Su, W., Zhu, Z., Dimitrov, D., Zhao, Q.. N-terminal α-amino group modification of antibodies using a site-selective click chemistry method[J]. mAbs, 2018, 712-719.
Authors:  Li, D.;  Han, B.;  Wei, R.;  Yao, G.;  Chen, Z.; et al.
Favorite | TC[WOS]:25 TC[Scopus]:26  IF:5.6/5.8 | Submit date：2022/08/31
Antibody  Antibody Engineering  Antibody-drug Conjugate  Clickchemistry  Site-specific Modification  
Recombinant-fully-human-antibody decorated highly-stable far-red AIEdots for in vivo HER-2 receptor-targeted imaging Journal article
Wu, Y, Chen, Z, Zhang, P, Zhou, L, Jiang, T, Chen, H, Gong, P, Dimitrov, D, Cai, L, Zhao, Q.. Recombinant-fully-human-antibody decorated highly-stable far-red AIEdots for in vivo HER-2 receptor-targeted imaging[J]. Chemical Communications, 2018, 7314-7317.
Authors:  Wu, Y;  Chen, Z;  Zhang, P;  Zhou, L;  Jiang, T; et al.
Favorite |   IF:4.3/4.4 | Submit date：2023/08/30
fully humanantibody  AIEdote  HER-2  
A dual-specific IGF-I/II human engineered antibody domain inhibits IGF signaling in breast cancer cells Journal article
Zhizhen Chen, Jie Liu, Dafeng Chu, Yaming Shan, Guixing Ma, Hongmin Zhang, Xiaohua Douglas Zhang, Pu Wang, Qiang Chen, Chuxia Deng, Weizao Chen, Dimiter Dimitrov, Qi Zhao. A dual-specific IGF-I/II human engineered antibody domain inhibits IGF signaling in breast cancer cells[J]. International Journal of Biological Sciences, 2018, 14(7), 799–806.
Authors:  Zhizhen Chen;  Jie Liu;  Dafeng Chu;  Yaming Shan;  Guixing Ma; et al.
Favorite | TC[WOS]:9 TC[Scopus]:9  IF:8.2/8.3 | Submit date：2018/12/17
Insulin-like Growth Factor  Yeast Display  Affinity Maturation  Ead  
Engineered antibody CH2 domains binding to nucleolin: isolation, characterization and improvement of aggregation Journal article
Li, D., Gong, R., Zheng, J., Chen, X., Dimitrov, D., Zhao, Q.. Engineered antibody CH2 domains binding to nucleolin: isolation, characterization and improvement of aggregation[J]. Biochemical and Biophysical Research Communications, 2017, 446-453.
Authors:  Li, D.;  Gong, R.;  Zheng, J.;  Chen, X.;  Dimitrov, D.; et al.
Favorite |   IF:2.5/2.7 | Submit date：2023/08/30
antibody domain  CH2  nucleolin  yeast display  monoclonal antibody  aggregation prone region  
A dual‐specific anti‐IGF‐1/IGF‐2 human monoclonal antibody alone and in combination with temsirolimus for therapy of neuroblastoma Journal article
Zhao, Q., Tran, H., Dimitrov, D., Cheung, N.. A dual‐specific anti‐IGF‐1/IGF‐2 human monoclonal antibody alone and in combination with temsirolimus for therapy of neuroblastoma[J]. International Journal of Cancer, 2015, 2243-2252.
Authors:  Zhao, Q.;  Tran, H.;  Dimitrov, D.;  Cheung, N.
Favorite |   IF:5.7/6.0 | Submit date：2023/08/30
IGF-1  IGF-2  chemotherapy  neuroblastoma  temsirolimus  
A dual-specific anti-IGF-1/IGF-2 human monoclonal antibody alone and in combination with temsirolimus for therapy of neuroblastoma Journal article
Zhao Q., Tran H., Dimitrov D.S., Cheung N.-K.V.. A dual-specific anti-IGF-1/IGF-2 human monoclonal antibody alone and in combination with temsirolimus for therapy of neuroblastoma[J]. International Journal of Cancer, 2015, 137(9), 2243-2252.
Authors:  Zhao Q.;  Tran H.;  Dimitrov D.S.;  Cheung N.-K.V.
Favorite | TC[WOS]:21 TC[Scopus]:21 | Submit date：2019/01/16
Chemotherapy  Igf-1  Igf-2  Neuroblastoma  Temsirolimus  
A new bispecific antibody targeting non-overlapping epitopes on IGF2: design, in vitro characterization and pharmacokinetics in macaques Journal article
Feng, Y., Zhao, Q., Chen, W., Wang, Y., Crowder, K., Dimitrov, D.. A new bispecific antibody targeting non-overlapping epitopes on IGF2: design, in vitro characterization and pharmacokinetics in macaques[J]. Experimental and molecular pathology, 2014, 359-367.
Authors:  Feng, Y.;  Zhao, Q.;  Chen, W.;  Wang, Y.;  Crowder, K.; et al.
Favorite |   IF:2.8/2.7 | Submit date：2023/08/30
Bispecific antibodies  Cynomolgus macaques  Half-life  IGF ligand.  
A new bispecific antibody targeting non-overlapping epitopes on IGF2: Design, in vitro characterization and pharmacokinetics in macaques Journal article
Feng Y., Zhao Q., Chen W., Wang Y., Crowder K., Dimitrov D.S.. A new bispecific antibody targeting non-overlapping epitopes on IGF2: Design, in vitro characterization and pharmacokinetics in macaques[J]. Experimental and Molecular Pathology, 2014, 97(3), 359-367.
Authors:  Feng Y.;  Zhao Q.;  Chen W.;  Wang Y.;  Crowder K.; et al.
Favorite | TC[WOS]:14 TC[Scopus]:14 | Submit date：2019/01/16
Bispecific Antibodies  Cynomolgus Macaques  Half-life  Igf Ligand  
Yeast display of engineered antibody domains Journal article
Zhao Q., Zhu Z., Dimitrov D.S.. Yeast display of engineered antibody domains[J]. Methods in Molecular Biology, 2012, 899, 73-84.
Authors:  Zhao Q.;  Zhu Z.;  Dimitrov D.S.
Favorite | TC[Scopus]:11 | Submit date：2019/01/16
Antibody Domain  Facs  Macs  Yeast Display