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Amelioration of Alzheimer’s disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow Journal article
Xie, Chenglong, Zhuang, Xu Xu, Niu, Zhangming, Ai, Ruixue, Lautrup, Sofie, Zheng, Shuangjia, Jiang, Yinghui, Han, Ruiyu, Gupta, Tanima Sen, Cao, Shuqin, Lagartos-Donate, Maria Jose, Cai, Cui-Zan, Xie, Li-Ming, Caponio, Domenica, Wang, Wen-Wen, Schmauck-Medina, Tomas, Zhang, Jianying, Wang, He-ling, Lou, Guofeng, Xiao, Xianglu, Zheng, Wenhua, Palikaras, Konstantinos, Yang, Guang, Caldwell, Kim A, Caldwell, Guy A., Shen, Han-Ming, Nilsen, Hilde, Lu, Jia-Hong, Fang, Evandro F.. Amelioration of Alzheimer’s disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow[J]. Nature Biomedical Engineering, 2022, 6(1), 76-93.
Authors:  Xie, Chenglong;  Zhuang, Xu Xu;  Niu, Zhangming;  Ai, Ruixue;  Lautrup, Sofie; et al.
Adobe PDF | Favorite | TC[WOS]:157 TC[Scopus]:165  IF:26.8/29.2 | Submit date：2022/12/12
Alzheimer’s Disease  Mitophagy Inducers  Machine Learning  Cross-species Workflow  
α-mangostin derivative 4e as a PDE4 inhibitor promote proteasomal degradation of alpha-synuclein in Parkinson's disease models through PKA activation Journal article
Chen, Jia Yue, Zhu, Qi, Cai, Cui Zan, Luo, Hai Bin, Lu, Jia Hong. α-mangostin derivative 4e as a PDE4 inhibitor promote proteasomal degradation of alpha-synuclein in Parkinson's disease models through PKA activation[J]. Phytomedicine, 2022, 101, 154125.
Authors:  Chen, Jia Yue;  Zhu, Qi;  Cai, Cui Zan;  Luo, Hai Bin;  Lu, Jia Hong
Favorite | TC[WOS]:8 TC[Scopus]:8  IF:6.7/6.2 | Submit date：2022/05/31
Alpha-synuclein (Α-syn)  Parkinson's Disease  Phosphodiesterase 4 Inhibitor  Protein Kinase a (Pka)  Ubiquitin-proteasome System (Ups)  
Emerging roles of NRBF2/PI3KC3 axis in maintaining homeostasis of brain and guts Journal article
Ming-Yue Wu, Cui-Zan Cai, Chuanbin Yang, Zhenyu Yue, Ye Chen, ZhaoXiang Bian, Min Li, Jia-Hong Lu. Emerging roles of NRBF2/PI3KC3 axis in maintaining homeostasis of brain and guts[J]. Neural Regeneration Research, 2022, 17(2), 323-324.
Authors:  Ming-Yue Wu;  Cui-Zan Cai;  Chuanbin Yang;  Zhenyu Yue;  Ye Chen; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:5.9/5.2 | Submit date：2022/03/04
Enhancing autophagy maturation with CCZ1-MON1A complex alleviates neuropathology and memory defects in Alzheimer disease models Journal article
Cai, Cui Zan, Zhuang, Xu Xu, Zhu, Qi, Wu, Ming Yue, Su, Huanxing, Wang, Xiao Jin, Iyaswamy, Ashok, Yue, Zhenyu, Wang, Qian, Zhang, Bin, Xue, Yu, Tan, Jieqiong, Li, Min, He, Huanhuan, Lu, Jia Hong. Enhancing autophagy maturation with CCZ1-MON1A complex alleviates neuropathology and memory defects in Alzheimer disease models[J]. Theranostics, 2022, 12(4), 1738-1755.
Authors:  Cai, Cui Zan;  Zhuang, Xu Xu;  Zhu, Qi;  Wu, Ming Yue;  Su, Huanxing; et al.
Favorite | TC[WOS]:17 TC[Scopus]:15  IF:12.4/12.0 | Submit date：2022/05/17
Alzheimer's Disease  Aβ  Autophagy  Ccz1-mon1a  Rab7  
Amelioration of Alzheimer’s disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow Journal article
Xie, Chenglong, Zhuang, Xu Xu, Niu, Zhangming, Ai, Ruixue, Lautrup, Sofie, Zheng, Shuangjia, Jiang, Yinghui, Han, Ruiyu, Gupta, Tanima Sen, Cao, Shuqin, Lagartos-Donate, Maria Jose, Cai, Cui Zan, Xie, Li Ming, Caponio, Domenica, Wang, Wen Wen, Schmauck-Medina, Tomas, Zhang, Jianying, Wang, He ling, Lou, Guofeng, Xiao, Xianglu, Zheng, Wenhua, Palikaras, Konstantinos, Yang, Guang, Caldwell, Kim A., Caldwell, Guy A., Shen, Han Ming, Nilsen, Hilde, Lu, Jia Hong, Fang, Evandro F.. Amelioration of Alzheimer’s disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow[J]. Nature Biomedical Engineering, 2022, 6(1), 76-93.
Authors:  Xie, Chenglong;  Zhuang, Xu Xu;  Niu, Zhangming;  Ai, Ruixue;  Lautrup, Sofie; et al.
Favorite | TC[WOS]:157 TC[Scopus]:166  IF:26.8/29.2 | Submit date：2022/02/21
Amelioration of Alzheimer's disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow Journal article
Xie, Chenglong, Zhuang, Xu-Xu, Niu, Zhangming, Ai, Ruixue, Lautrup, Sofie, Zheng, Shuangjia, Jiang, Yinghui, Han, Ruiyu, Gupta, Tanima Sen, Cao, Shuqin, Lagartos-Donate, Maria Jose, Cai, Cui-Zan, Xie, Li-Ming, Caponio, Domenica, Wang, Wen-Wen, Schmauck-Medina, Tomas, Zhang, Jianying, Wang, He-ling, Lou, Guofeng, Xiao, Xianglu, Zheng, Wenhua, Palikaras, Konstantinos, Yang, Guang, Caldwell, Kim A, Caldwell, Guy A., Shen, Han-Ming, Nilsen, Hilde, Lu, Jia-Hong, Fang, Evandro F.. Amelioration of Alzheimer's disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow[J]. Nature Biomedical Engineering, 2021, 6(1), 76 - 93.
Authors:  Xie, Chenglong;  Zhuang, Xu-Xu;  Niu, Zhangming;  Ai, Ruixue;  Lautrup, Sofie; et al.
Favorite | TC[WOS]:157 TC[Scopus]:166  IF:26.8/29.2 | Submit date：2022/08/31
Alzheimer’s Disease  Mitophagy Inducers  Machine Learning  Cross-species Workflow  
PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation Journal article
Wu,Ming Yue, Liu,Le, Wang,Er Jin, Xiao,Hai Tao, Cai,Cui Zan, Wang,Jing, Su,Huanxing, Wang,Yitao, Tan,Jieqiong, Zhang,Zhuohua, Wang,Juan, Yao,Maojing, Ouyang,De Fang, Yue,Zhenyu, Li,Min, Chen,Ye, Bian,Zhao Xiang, Lu,Jia Hong. PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation[J]. Autophagy, 2021, 17(5), 1096-1111.
Authors:  Wu,Ming Yue;  Liu,Le;  Wang,Er Jin;  Xiao,Hai Tao;  Cai,Cui Zan; et al.
Favorite | TC[WOS]:56 TC[Scopus]:51  IF:14.6/16.8 | Submit date：2021/03/01
Apoptotic Cell Clearance  Inflammatory Bowel Disease  Macrophage  Mon1-ccz1  Nrbf2  Rab7  
Lycorine, a natural alkaloid, promotes the degradation of alpha-synuclein via PKA-mediated UPS activation in transgenic Parkinson's disease models Journal article
Zhu, Qi, Zhuang, Xu xu, Chen, Jia yue, Yuan, Ning ning, Chen, Yan, Cai, Cui zan, Tan, Jie qiong, Su, Huan xing, Lu, Jia hong. Lycorine, a natural alkaloid, promotes the degradation of alpha-synuclein via PKA-mediated UPS activation in transgenic Parkinson's disease models[J]. Phytomedicine, 2021, 87, 153578.
Authors:  Zhu, Qi;  Zhuang, Xu xu;  Chen, Jia yue;  Yuan, Ning ning;  Chen, Yan; et al.
Favorite | TC[WOS]:17 TC[Scopus]:18  IF:6.7/6.2 | Submit date：2021/12/08
Camp/pka Pathway  Lycorine  Parkinson's Disease  Ubiquitin-proteasome System  Α-synuclein  
Comprehensive perspectives on experimental models for Parkinson's disease Journal article
Ke, Minjing, Chong, Cheong Meng, Zhu, Qi, Zhang, Ke, Cai, Cui Zan, Lu, Jia Hong, Qin, Dajiang, Su, Huanxing. Comprehensive perspectives on experimental models for Parkinson's disease[J]. Aging and Disease, 2021, 12(1), 223-246.
Authors:  Ke, Minjing;  Chong, Cheong Meng;  Zhu, Qi;  Zhang, Ke;  Cai, Cui Zan; et al.
Favorite | TC[WOS]:18 TC[Scopus]:17  IF:7.0/7.1 | Submit date：2021/12/07
Cellular Model  Cross-species Model  Experimental Model  Parkinson's Disease  Transgenic Animal  
NRBF2 is a RAB7 effector required for autophagosome maturation and mediates the association of APP-CTFs with active form of RAB7 for degradation Journal article
Cai,Cui Zan, Yang,Chuanbin, Zhuang,Xu Xu, Yuan,Ning Ning, Wu,Ming Yue, Tan,Jie Qiong, Song,Ju Xian, Cheung,King Ho, Su,Huanxing, Wang,Yi Tao, Tang,Bei Sha, Behrends,Christian, Durairajan,Siva Sundara Kumar, Yue,Zhenyu, Li,Min, Lu,Jia Hong. NRBF2 is a RAB7 effector required for autophagosome maturation and mediates the association of APP-CTFs with active form of RAB7 for degradation[J]. Autophagy, 2020, 17(5), 1112-1130.
Authors:  Cai,Cui Zan;  Yang,Chuanbin;  Zhuang,Xu Xu;  Yuan,Ning Ning;  Wu,Ming Yue; et al.
Favorite | TC[WOS]:30 TC[Scopus]:33  IF:14.6/16.8 | Submit date：2021/03/01
Amaturation  Autophagy  Ccz1-mon1a  Nrbf2  Pi3kc3/ Vps34  Rab7  Trafficking