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Discovery of potent LRRK2 inhibitors by ensemble virtual screening strategy and bioactivity evaluation Journal article
Gong, Xiaoqing, Li, Shuli, Huang, Junli, Tan, Shuoyan, Zhang, Qianqian, Tian, Yanan, Li, Qin, Wang, Lingling, Tong, Henry H.Y., Yao, Xiaojun, Chen, Chunxia, Lee, Simon Ming Yuen, Liu, Huanxiang. Discovery of potent LRRK2 inhibitors by ensemble virtual screening strategy and bioactivity evaluation[J]. European Journal of Medicinal Chemistry, 2024, 279, 116812.
Authors:  Gong, Xiaoqing;  Li, Shuli;  Huang, Junli;  Tan, Shuoyan;  Zhang, Qianqian; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:6.0/6.1 | Submit date：2024/10/10
Fingerprint  Lrrk2  Molecular Docking  Pharmacophore  Virtual Screening  Zebrafish  
Isoalantolactone/hydroxamic acid hybrids as potent dual STAT3/HDAC inhibitors and self-assembled nanoparticles for cancer therapy Journal article
Mo, Hualong, Liu, Jie Ying, Su, Zhengxi, Zhao, Deng Gao, Ma, Yan Yan, Zhang, Kun, Wang, Qi, Fu, Chun, Wang, Yao, Chen, Meiwan, Hu, Burong. Isoalantolactone/hydroxamic acid hybrids as potent dual STAT3/HDAC inhibitors and self-assembled nanoparticles for cancer therapy[J]. European Journal of Medicinal Chemistry, 2024, 277, 116765.
Authors:  Mo, Hualong;  Liu, Jie Ying;  Su, Zhengxi;  Zhao, Deng Gao;  Ma, Yan Yan; et al.
Favorite | TC[WOS]:1 TC[Scopus]:1  IF:6.0/6.1 | Submit date：2024/09/03
Antitumor  Hdac  Isoalantolactone  Self-assembled Nanoparticles  Stat3  
A glycyrrhetinic acid-iridium(III) conjugate as a theranostic NIR probe for hepatocellular carcinoma with mitochondrial-targeting ability Journal article
Wang, Ling, Wang, Xueliang, Chen, Feng, Song, Ying Qi, Nao, Sang Cuo, Chan, Daniel Shiu Hin, Wong, Chun Yuen, Wang, Wanhe, Leung, Chung Hang. A glycyrrhetinic acid-iridium(III) conjugate as a theranostic NIR probe for hepatocellular carcinoma with mitochondrial-targeting ability[J]. European Journal of Medicinal Chemistry, 2024, 264, 115995.
Authors:  Wang, Ling;  Wang, Xueliang;  Chen, Feng;  Song, Ying Qi;  Nao, Sang Cuo; et al.
Favorite | TC[WOS]:3 TC[Scopus]:3  IF:6.0/6.1 | Submit date：2024/02/22
Glycyrrhetinic Acid (Ga)  Hepatocellular Carcinoma  Iridium(Iii) Complex  Mitochondrial Targeting  Nir Imaging  Theranostic  
A cell-impermeable luminogenic probe for near-infrared imaging of prostate-specific membrane antigen in prostate cancer microenvironments Journal article
Yang,Xifang, Nao,Sang Cuo, Lin,Chuankai, Kong,Lingtan, Wang,Jing, Ko,Chung Nga, Liu,Jinbiao, Ma,Dik Lung, Leung,Chung Hang, Wang,Wanhe. A cell-impermeable luminogenic probe for near-infrared imaging of prostate-specific membrane antigen in prostate cancer microenvironments[J]. European Journal of Medicinal Chemistry, 2023, 259, 115659.
Authors:  Yang,Xifang;  Nao,Sang Cuo;  Lin,Chuankai;  Kong,Lingtan;  Wang,Jing; et al.
Favorite | TC[WOS]:5 TC[Scopus]:6  IF:6.0/6.1 | Submit date：2023/08/03
Nir  Luminogenic Probe  Cell Impermeability  Wash-free  Iridium(Iii) Complex  Prostate Cancer  Prostate-specific Membrane Antigen  
Rational Design of Covalent Kinase Inhibitors by an Integrated Computational Workflow (Kin-Cov) Journal article
Zhou, Yang, Yu, Hang, Vind, Anna Constance, Kong, Lulu, Liu, Yiling, Song, Xiaojuan, Tu, Zhengchao, Yun, Caihong, Smaill, Jeff B., Zhang, Qing Wen, Ding, Ke, Bekker-Jensen, Simon, Lu, Xiaoyun. Rational Design of Covalent Kinase Inhibitors by an Integrated Computational Workflow (Kin-Cov)[J]. Journal of Medicinal Chemistry, 2023, 66(11), 7405-7420.
Authors:  Zhou, Yang;  Yu, Hang;  Vind, Anna Constance;  Kong, Lulu;  Liu, Yiling; et al.
Favorite | TC[WOS]:1 TC[Scopus]:1  IF:6.8/7.1 | Submit date：2023/07/19
Enantioselective semisynthesis of novel cephalotaxine esters with potent antineoplastic activities against leukemia Journal article
Yujian Yang, Qiuchun Yu, Lean Hu, Botao Dai, Ruxi Qi, Yu Chang, Qingwen Zhang, Zhang Zhang, Yingjun Li, Xumu Zhang. Enantioselective semisynthesis of novel cephalotaxine esters with potent antineoplastic activities against leukemia[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 244, 114731.
Authors:  Yujian Yang;  Qiuchun Yu;  Lean Hu;  Botao Dai;  Ruxi Qi; et al.
Favorite | TC[WOS]:5 TC[Scopus]:4  IF:6.0/6.1 | Submit date：2023/01/10
Cephalotaxine-type Alkaloid  Homoharringtonine  Leukemia  Antineoplastics  Enantioselective Semisynthesis  Asymmetric Hydrogenation  
Recent two-year advances in anti-dengue small-molecule inhibitors Journal article
Yang, Chao, Xie, Wansheng, Zhang, Heqian, Xie, Wenjian, Tian, Tiantian, Qin, Zhiwei. Recent two-year advances in anti-dengue small-molecule inhibitors[J]. European Journal of Medicinal Chemistry, 2022, 243.
Authors:  Yang, Chao;  Xie, Wansheng;  Zhang, Heqian;  Xie, Wenjian;  Tian, Tiantian; et al.
Favorite | TC[WOS]:4 TC[Scopus]:4  IF:6.0/6.1 | Submit date：2023/01/30
Aedes Aegypti  Dengue Fever  Flaviviruses  Inhibitors  Tropical Diseases  
ChemistGA: A Chemical Synthesizable Accessible Molecular Generation Algorithm for Real-World Drug Discovery Journal article
Wang, Jike, Wang, Xiaorui, Sun, Huiyong, Wang, Mingyang, Zeng, Yundian, Jiang, Dejun, Wu, Zhenxing, Liu, Zeyi, Liao, Ben, Yao, Xiaojun, Hsieh, Chang Yu, Cao, Dongsheng, Chen, Xi, Hou, Tingjun. ChemistGA: A Chemical Synthesizable Accessible Molecular Generation Algorithm for Real-World Drug Discovery[J]. Journal of Medicinal Chemistry, 2022, 65(18), 12482-12496.
Authors:  Wang, Jike;  Wang, Xiaorui;  Sun, Huiyong;  Wang, Mingyang;  Zeng, Yundian; et al.
Favorite | TC[WOS]:9 TC[Scopus]:13  IF:6.8/7.1 | Submit date：2023/01/30
Design, synthesis and antitumor evaluation of novel 1H-indole-2-carboxylic acid derivatives targeting 14-3-3η protein Journal article
Gao, Zhenxiong, Fan, Tingting, Chen, Linbo, Yang, Mengchu, Wai Wong, Vincent Kam, Chen, Dawei, Liu, Zijian, Zhou, Yaoyao, Wu, Weibin, Qiu, Zixuan, Zhang, Cunlong, Li, Yuan, Jiang, Yuyang. Design, synthesis and antitumor evaluation of novel 1H-indole-2-carboxylic acid derivatives targeting 14-3-3η protein[J]. European Journal of Medicinal Chemistry, 2022, 238.
Authors:  Gao, Zhenxiong;  Fan, Tingting;  Chen, Linbo;  Yang, Mengchu;  Wai Wong, Vincent Kam; et al.
Favorite | TC[WOS]:3 TC[Scopus]:3  IF:6.0/6.1 | Submit date：2023/01/30
14-3-3η Protein  Antitumor Bioactivity  Drug Design  Hepatocellular Carcinoma  Novel Target  
RELATION: A Deep Generative Model for Structure-Based De Novo Drug Design Journal article
Wang, Mingyang, Hsieh, Chang Yu, Wang, Jike, Wang, Dong, Weng, Gaoqi, Shen, Chao, Yao, Xiaojun, Bing, Zhitong, Li, Honglin, Cao, Dongsheng, Hou, Tingjun. RELATION: A Deep Generative Model for Structure-Based De Novo Drug Design[J]. Journal of Medicinal Chemistry, 2022, 65(13), 9478-9492.
Authors:  Wang, Mingyang;  Hsieh, Chang Yu;  Wang, Jike;  Wang, Dong;  Weng, Gaoqi; et al.
Favorite | TC[WOS]:33 TC[Scopus]:41  IF:6.8/7.1 | Submit date：2023/01/30