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Development of small molecule inhibitors targeting RNA helicase DHX33 as anti-cancer agents Journal article
Wang, Yingcai, Nie, Guangli, Wang, Xingshun, Ge, Wei, Zhang, Yandong. Development of small molecule inhibitors targeting RNA helicase DHX33 as anti-cancer agents[J]. Bioorganic and Medicinal Chemistry Letters, 2023, 96, 129505.
Authors:  Wang, Yingcai;  Nie, Guangli;  Wang, Xingshun;  Ge, Wei;  Zhang, Yandong
Favorite | TC[WOS]:2 TC[Scopus]:2  IF:2.5/2.4 | Submit date：2023/12/04
Cancer  Dhx33  Rna Helicase  Inhibitor High Throughput Screening (Hts)  
Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships Journal article
Zhang,Shao Lin, Yang,Zheng, Hu,Xiaohui, Tam,Kin Yip. Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships[J]. Bioorganic and Medicinal Chemistry Letters, 2018, 28(21), 3441-3445.
Authors:  Zhang,Shao Lin;  Yang,Zheng;  Hu,Xiaohui;  Tam,Kin Yip
Favorite | TC[WOS]:16 TC[Scopus]:16  IF:2.5/2.4 | Submit date：2021/03/04
Antiproliferative Activity  Dichloroacetophenone  Kinase Inhibition  Pyruvate Dehydrogenase Complex  Pyruvate Dehydrogenase Kinase  
Study the interactions between human serum albumin and two antifungal drugs: Fluconazole and its analogue DTP Journal article
Zhang,Shao Lin, Yao,Huankai, Wang,Chenyin, Tam,Kin Y.. Study the interactions between human serum albumin and two antifungal drugs: Fluconazole and its analogue DTP[J]. Bioorganic and Medicinal Chemistry Letters, 2014, 24(21), 4963-4968.
Authors:  Zhang,Shao Lin;  Yao,Huankai;  Wang,Chenyin;  Tam,Kin Y.
Favorite | TC[WOS]:17 TC[Scopus]:17  IF:2.5/2.4 | Submit date：2021/03/04
Binding Affinity  Fluconazole  Fluorescence Spectrum  Human Serum Albumin  Molecular Docking  
Study the interactions between human serum albumin and two antifungal drugs: Fluconazole and its analogue DTP Journal article
Zhang S.-L., Yao H., Wang C., Tam K.Y.. Study the interactions between human serum albumin and two antifungal drugs: Fluconazole and its analogue DTP[J]. Bioorganic and Medicinal Chemistry Letters, 2014, 24(21), 4963-4968.
Authors:  Zhang S.-L.;  Yao H.;  Wang C.;  Tam K.Y.
Favorite | TC[WOS]:17 TC[Scopus]:17 | Submit date：2018/12/18
Binding Affinity  Fluconazole  Fluorescence Spectrum  Human Serum Albumin  Molecular Docking  
Substituted 3-(4-(1,3,5-triazin-2-yl)-phenyl)-2-aminopropanoic acids as novel tryptophan hydroxylase inhibitors Journal article
Jin H., Cianchetta G., Devasagayaraj A., Gu K., Marinelli B., Samala L., Scott S., Stouch T., Tunoori A., Wang Y., Zang Y., Zhang C., David Kimball S., Main A.J., Ding Z.-M., Sun W., Yang Q., Yu X.-Q., Powell D.R., Wilson A., Liu Q., Shi Z.-C.. Substituted 3-(4-(1,3,5-triazin-2-yl)-phenyl)-2-aminopropanoic acids as novel tryptophan hydroxylase inhibitors[J]. Bioorganic and Medicinal Chemistry Letters, 2009, 19(17), 5229-5232.
Authors:  Jin H.;  Cianchetta G.;  Devasagayaraj A.;  Gu K.;  Marinelli B.; et al.
Favorite | TC[WOS]:32 TC[Scopus]:31 | Submit date：2019/01/16
5-ht  Gastrointestinal Disorders  Tph1  Tryptophan Hydroxylase  
Synthesis and evaluation of heteroaryl-ketone derivatives as a novel class of VEGFR-2 inhibitors Journal article
Piatnitski Chekler E.L., Katoch-Rouse R., Kiselyov A.S., Sherman D., Ouyang X., Kim K., Wang Y., Hadari Y.R., Doody J.F.. Synthesis and evaluation of heteroaryl-ketone derivatives as a novel class of VEGFR-2 inhibitors[J]. Bioorganic and Medicinal Chemistry Letters, 2008, 18(15), 4344-4347.
Authors:  Piatnitski Chekler E.L.;  Katoch-Rouse R.;  Kiselyov A.S.;  Sherman D.;  Ouyang X.; et al.
Favorite | TC[WOS]:11 TC[Scopus]:11 | Submit date：2019/01/16
Angiogenesis  Kinase Inhibitor  Vascular Endothelial Growth Factor  
Structural analogs of tylophora alkaloids may not be functional analogs Journal article
Gao W., Chen A.P.-C., Leung C.-H., Gullen E.A., Furstner A., Shi Q., Wei L., Lee K.-H., Cheng Y.-C.. Structural analogs of tylophora alkaloids may not be functional analogs[J]. Bioorganic and Medicinal Chemistry Letters, 2008, 18(2), 704-709.
Authors:  Gao W.;  Chen A.P.-C.;  Leung C.-H.;  Gullen E.A.;  Furstner A.; et al.
Favorite | TC[WOS]:64 TC[Scopus]:65 | Submit date：2018/11/06
Protein, Dna, And Rna Synthesis  Structure-activity Relationship  Tylophora Alkaloids  
Novel tricyclic azepine derivatives: Biological evaluation of pyrimido[4,5-b]-1,4-benzoxazepines, thiazepines, and diazepines as inhibitors of the epidermal growth factor receptor tyrosine kinase Journal article
Smith II L., Wong W.C., Kiselyov A.S., Burdzovic-Wizemann S., Mao Y., Xu Y., Duncton M.A.J., Kim K., Piatnitski E.L., Doody J.F., Wang Y., Rosler R.L., Milligan D., Columbus J., Balagtas C., Lee S.P., Konovalov A., Hadari Y.R.. Novel tricyclic azepine derivatives: Biological evaluation of pyrimido[4,5-b]-1,4-benzoxazepines, thiazepines, and diazepines as inhibitors of the epidermal growth factor receptor tyrosine kinase[J]. Bioorganic and Medicinal Chemistry Letters, 2006, 16(19), 5102-5106.
Authors:  Smith II L.;  Wong W.C.;  Kiselyov A.S.;  Burdzovic-Wizemann S.;  Mao Y.; et al.
Favorite | TC[WOS]:33 TC[Scopus]:38 | Submit date：2019/01/16
Diazepine  Epidermal Growth Factor Receptor  Kinase Inhibitor  Oxazepine  Thiazepine  
Tricyclic azepine derivatives: Pyrimido[4,5-b]-1,4-benzoxazepines as a novel class of epidermal growth factor receptor kinase inhibitors Journal article
Smith II L., Piatnitski E.L., Kiselyov A.S., Ouyang X., Chen X., Burdzovic-Wizemann S., Xu Y., Wang Y., Rosler R.L., Patel S.N., Chiang H.-H., Milligan D.L., Columbus J., Wong W.C., Doody J.F., Hadari Y.R.. Tricyclic azepine derivatives: Pyrimido[4,5-b]-1,4-benzoxazepines as a novel class of epidermal growth factor receptor kinase inhibitors[J]. Bioorganic and Medicinal Chemistry Letters, 2006, 16(6), 1643-1646.
Authors:  Smith II L.;  Piatnitski E.L.;  Kiselyov A.S.;  Ouyang X.;  Chen X.; et al.
Favorite | TC[WOS]:20 TC[Scopus]:19 | Submit date：2019/01/16
Benzoxazepine  Epidermal Growth Factor Receptor  Kinase Inhibitor  Kinase Selectivity  
Oxadiazole derivatives as a novel class of antimitotic agents: Synthesis, inhibition of tubulin polymerization, and activity in tumor cell lines Journal article
Ouyang X., Piatnitski E.L., Pattaropong V., Chen X., He H.-Y., Kiselyov A.S., Velankar A., Kawakami J., Labelle M., Smith II L., Lohman J., Lee S.P., Malikzay A., Fleming J., Gerlak J., Wang Y., Rosler R.L., Zhou K., Mitelman S., Camara M., Surguladze D., Doody J.F., Tuma M.C.. Oxadiazole derivatives as a novel class of antimitotic agents: Synthesis, inhibition of tubulin polymerization, and activity in tumor cell lines[J]. Bioorganic and Medicinal Chemistry Letters, 2006, 16(5), 1191-1196.
Authors:  Ouyang X.;  Piatnitski E.L.;  Pattaropong V.;  Chen X.;  He H.-Y.; et al.
Favorite | TC[WOS]:99 TC[Scopus]:104 | Submit date：2019/01/16
1,3,4-oxadiazole  Antimitotic Agent  Multiple-drug Resistance  Tubulin Polymerization Inhibitor