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Development of small molecule inhibitors targeting RNA helicase DHX33 as anti-cancer agents Journal article
Wang, Yingcai, Nie, Guangli, Wang, Xingshun, Ge, Wei, Zhang, Yandong. Development of small molecule inhibitors targeting RNA helicase DHX33 as anti-cancer agents[J]. Bioorganic and Medicinal Chemistry Letters, 2023, 96, 129505.
Authors:  Wang, Yingcai;  Nie, Guangli;  Wang, Xingshun;  Ge, Wei;  Zhang, Yandong
Favorite | TC[WOS]:2 TC[Scopus]:2  IF:2.5/2.4 | Submit date：2023/12/04
Cancer  Dhx33  Rna Helicase  Inhibitor High Throughput Screening (Hts)  
Synthesis and biological effect of lysosome-targeting fluorescent anion transporters with enhanced anionophoric activity Journal article
Hong,Xiao Qiao, He,Xiang Yu, Tam,Kin Yip, Chen,Wen Hua. Synthesis and biological effect of lysosome-targeting fluorescent anion transporters with enhanced anionophoric activity[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 30(19), 127461.
Authors:  Hong,Xiao Qiao;  He,Xiang Yu;  Tam,Kin Yip;  Chen,Wen Hua
Favorite | TC[WOS]:7 TC[Scopus]:7  IF:2.5/2.4 | Submit date：2021/03/04
Fluorescent Anion Transporter  Lysosome Targeting  Lysosomal Alkalization  Cathepsin b Enzyme  
Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships Journal article
Zhang,Shao Lin, Yang,Zheng, Hu,Xiaohui, Tam,Kin Yip. Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships[J]. Bioorganic and Medicinal Chemistry Letters, 2018, 28(21), 3441-3445.
Authors:  Zhang,Shao Lin;  Yang,Zheng;  Hu,Xiaohui;  Tam,Kin Yip
Favorite | TC[WOS]:16 TC[Scopus]:16  IF:2.5/2.4 | Submit date：2021/03/04
Antiproliferative Activity  Dichloroacetophenone  Kinase Inhibition  Pyruvate Dehydrogenase Complex  Pyruvate Dehydrogenase Kinase  
Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships Journal article
Zhang, Shao-Lin, Yang, Zheng, Hu, Xiaohui, Tam, Kin Yip. Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 28(21), 3441-3445.
Authors:  Zhang, Shao-Lin;  Yang, Zheng;  Hu, Xiaohui;  Tam, Kin Yip
Favorite | TC[WOS]:16 TC[Scopus]:16  IF:2.5/2.4 | Submit date：2018/10/30
Pyruvate Dehydrogenase Kinase  Pyruvate Dehydrogenase Complex  Antiproliferative Activity  Dichloroacetophenone  Kinase Inhibition  
Study the interactions between human serum albumin and two antifungal drugs: Fluconazole and its analogue DTP Journal article
Zhang,Shao Lin, Yao,Huankai, Wang,Chenyin, Tam,Kin Y.. Study the interactions between human serum albumin and two antifungal drugs: Fluconazole and its analogue DTP[J]. Bioorganic and Medicinal Chemistry Letters, 2014, 24(21), 4963-4968.
Authors:  Zhang,Shao Lin;  Yao,Huankai;  Wang,Chenyin;  Tam,Kin Y.
Favorite | TC[WOS]:17 TC[Scopus]:17  IF:2.5/2.4 | Submit date：2021/03/04
Binding Affinity  Fluconazole  Fluorescence Spectrum  Human Serum Albumin  Molecular Docking  
Study the interactions between human serum albumin and two antifungal drugs: Fluconazole and its analogue DTP Journal article
Zhang S.-L., Yao H., Wang C., Tam K.Y.. Study the interactions between human serum albumin and two antifungal drugs: Fluconazole and its analogue DTP[J]. Bioorganic and Medicinal Chemistry Letters, 2014, 24(21), 4963-4968.
Authors:  Zhang S.-L.;  Yao H.;  Wang C.;  Tam K.Y.
Favorite | TC[WOS]:17 TC[Scopus]:17 | Submit date：2018/12/18
Binding Affinity  Fluconazole  Fluorescence Spectrum  Human Serum Albumin  Molecular Docking  
Substituted 3-(4-(1,3,5-triazin-2-yl)-phenyl)-2-aminopropanoic acids as novel tryptophan hydroxylase inhibitors Journal article
Jin H., Cianchetta G., Devasagayaraj A., Gu K., Marinelli B., Samala L., Scott S., Stouch T., Tunoori A., Wang Y., Zang Y., Zhang C., David Kimball S., Main A.J., Ding Z.-M., Sun W., Yang Q., Yu X.-Q., Powell D.R., Wilson A., Liu Q., Shi Z.-C.. Substituted 3-(4-(1,3,5-triazin-2-yl)-phenyl)-2-aminopropanoic acids as novel tryptophan hydroxylase inhibitors[J]. Bioorganic and Medicinal Chemistry Letters, 2009, 19(17), 5229-5232.
Authors:  Jin H.;  Cianchetta G.;  Devasagayaraj A.;  Gu K.;  Marinelli B.; et al.
Favorite | TC[WOS]:32 TC[Scopus]:31 | Submit date：2019/01/16
5-ht  Gastrointestinal Disorders  Tph1  Tryptophan Hydroxylase  
Synthesis and evaluation of heteroaryl-ketone derivatives as a novel class of VEGFR-2 inhibitors Journal article
Piatnitski Chekler E.L., Katoch-Rouse R., Kiselyov A.S., Sherman D., Ouyang X., Kim K., Wang Y., Hadari Y.R., Doody J.F.. Synthesis and evaluation of heteroaryl-ketone derivatives as a novel class of VEGFR-2 inhibitors[J]. Bioorganic and Medicinal Chemistry Letters, 2008, 18(15), 4344-4347.
Authors:  Piatnitski Chekler E.L.;  Katoch-Rouse R.;  Kiselyov A.S.;  Sherman D.;  Ouyang X.; et al.
Favorite | TC[WOS]:11 TC[Scopus]:11 | Submit date：2019/01/16
Angiogenesis  Kinase Inhibitor  Vascular Endothelial Growth Factor  
Structural analogs of tylophora alkaloids may not be functional analogs Journal article
Gao W., Chen A.P.-C., Leung C.-H., Gullen E.A., Furstner A., Shi Q., Wei L., Lee K.-H., Cheng Y.-C.. Structural analogs of tylophora alkaloids may not be functional analogs[J]. Bioorganic and Medicinal Chemistry Letters, 2008, 18(2), 704-709.
Authors:  Gao W.;  Chen A.P.-C.;  Leung C.-H.;  Gullen E.A.;  Furstner A.; et al.
Favorite | TC[WOS]:64 TC[Scopus]:65 | Submit date：2018/11/06
Protein, Dna, And Rna Synthesis  Structure-activity Relationship  Tylophora Alkaloids  
Novel tricyclic azepine derivatives: Biological evaluation of pyrimido[4,5-b]-1,4-benzoxazepines, thiazepines, and diazepines as inhibitors of the epidermal growth factor receptor tyrosine kinase Journal article
Smith II L., Wong W.C., Kiselyov A.S., Burdzovic-Wizemann S., Mao Y., Xu Y., Duncton M.A.J., Kim K., Piatnitski E.L., Doody J.F., Wang Y., Rosler R.L., Milligan D., Columbus J., Balagtas C., Lee S.P., Konovalov A., Hadari Y.R.. Novel tricyclic azepine derivatives: Biological evaluation of pyrimido[4,5-b]-1,4-benzoxazepines, thiazepines, and diazepines as inhibitors of the epidermal growth factor receptor tyrosine kinase[J]. Bioorganic and Medicinal Chemistry Letters, 2006, 16(19), 5102-5106.
Authors:  Smith II L.;  Wong W.C.;  Kiselyov A.S.;  Burdzovic-Wizemann S.;  Mao Y.; et al.
Favorite | TC[WOS]:33 TC[Scopus]:38 | Submit date：2019/01/16
Diazepine  Epidermal Growth Factor Receptor  Kinase Inhibitor  Oxazepine  Thiazepine