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Ivacaftor, a CFTR potentiator, synergizes with osimertinib against acquired resistance to osimertinib in NSCLC by regulating CFTR-PTEN-AKT axis Journal article
Li, Yue Kang, Ge, Fu Jing, Liu, Xiang Ning, Zeng, Chen Ming, Qian, Mei Jia, Li, Yong Hao, Zheng, Ming Ming, Qu, Jing Jing, Fang, Liang Jie, Lu, Jin Jian, Yang, Bo, He, Qiao Jun, Zhou, Jian Ya, Zhu, Hong. Ivacaftor, a CFTR potentiator, synergizes with osimertinib against acquired resistance to osimertinib in NSCLC by regulating CFTR-PTEN-AKT axis[J]. Acta Pharmacologica Sinica, 2024.
Authors:  Li, Yue Kang;  Ge, Fu Jing;  Liu, Xiang Ning;  Zeng, Chen Ming;  Qian, Mei Jia; et al.
Favorite | TC[WOS]:0 TC[Scopus]:1  IF:6.9/7.6 | Submit date：2024/12/26
Acquired Resistance  Cftr  Ivacaftor  Nsclc  Osimertinib  
Correction to: E3 ubiquitin ligase UBR5 modulates circadian rhythm by facilitating the ubiquitination and degradation of the key clock transcription factor BMAL1 (Acta Pharmacologica Sinica, (2024), 10.1038/s41401-024-01290-z) Other
2024-12-01
Authors:  Duan, Chun Yan;  Li, Yue;  Zhi, Hao Yu;  Tian, Yao;  Huang, Zheng Yun; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0 | Submit date：2024/07/04
SP600125, a selective JNK inhibitor, is a potent inhibitor of NAD(P)H: quinone oxidoreductase 1 (NQO1) Journal article
Zhong, Bing Ling, Zhang, Yi Fei, Zheng, Hao Yi, Chen, Qiang, Lu, Hua Dong, Chen, Xiu Ping. SP600125, a selective JNK inhibitor, is a potent inhibitor of NAD(P)H: quinone oxidoreductase 1 (NQO1)[J]. Acta Pharmacologica Sinica, 2024.
Authors:  Zhong, Bing Ling;  Zhang, Yi Fei;  Zheng, Hao Yi;  Chen, Qiang;  Lu, Hua Dong; et al.
Favorite | TC[WOS]:0 TC[Scopus]:1  IF:6.9/7.6 | Submit date：2024/12/05
Jnk  Nqo1  Sp600125  
Artemisinin inhibits neuronal ferroptosis in Alzheimer's disease models by targeting KEAP1 Journal article
Peng-xi Deng, Marta Silva, Na Yang, Qing Wang, Xin Meng, Ke-qiang Ye, Hong-chang Gao, ZHENG WENHUA. Artemisinin inhibits neuronal ferroptosis in Alzheimer's disease models by targeting KEAP1[J]. Acta Pharmacologica Sinica, 2024.
Authors:  Peng-xi Deng;  Marta Silva;  Na Yang;  Qing Wang;  Xin Meng; et al.
Favorite | TC[WOS]:1 TC[Scopus]:0  IF:6.9/7.6 | Submit date：2024/08/31
Alzheimer's Disease  Artemisinin  Ferroptosis  Keap1  Nrf2  Hippocampus  
E3 ubiquitin ligase UBR5 modulates circadian rhythm by facilitating the ubiquitination and degradation of the key clock transcription factor BMAL1 Journal article
Duan, Chunyan, Li, Yue, Zhi, Haoyu, Tian, Yao, Huang, Zhengyun, Chen, Suping, Zhang, Yang, Liu, Qing, Zhou, Liang, Jiang, Xiaogang, Ullah, Kifayat, Guo, Qing, Liu, Zhaohui, Xu, Ying, Han, Junhai, Hou, Jiajie, O’Connor, Darran P., Xu, Guo qiang. E3 ubiquitin ligase UBR5 modulates circadian rhythm by facilitating the ubiquitination and degradation of the key clock transcription factor BMAL1[J]. ACTA PHARMACOLOGICA SINICA, 2024, 45(9), 1793-1808.
Authors:  Duan, Chunyan;  Li, Yue;  Zhi, Haoyu;  Tian, Yao;  Huang, Zhengyun; et al.
Favorite | TC[WOS]:2 TC[Scopus]:1  IF:6.9/7.6 | Submit date：2024/06/05
Bmal1  Circadian Rhythm  Proteomics  Transcriptional Activity  Ubiquitination  Ubr5  
Novel STAT3 oligonucleotide compounds suppress tumor growth and overcome the acquired resistance to sorafenib in hepatocellular carcinoma Journal article
Zhang, Qi Yi, Ding, Wen, Mo, Jian Shan, Ou-yang, Shu Min, Lin, Zi You, Peng, Ke Ren, Liu, Guo Pin, Lu, Jin Jian, Yue, Pei Bin, Lei, Jin Ping, Wang, Yan Dong, Zhang, Xiao Lei. Novel STAT3 oligonucleotide compounds suppress tumor growth and overcome the acquired resistance to sorafenib in hepatocellular carcinoma[J]. ACTA PHARMACOLOGICA SINICA, 2024.
Authors:  Zhang, Qi Yi;  Ding, Wen;  Mo, Jian Shan;  Ou-yang, Shu Min;  Lin, Zi You; et al.
Favorite | TC[WOS]:6 TC[Scopus]:7  IF:6.9/7.6 | Submit date：2024/05/16
Acquired Sorafenib-resistance  Antisense Oligonucleotide  Hepatocellular Carcinoma  Stat3  
Paraptosis: a non-classical paradigm of cell death for cancer therapy Journal article
Xu, Chun cao, Lin, Yi fan, Huang, Mu yang, Zhang, Xiao lei, Wang, Pei, Huang, Ming qing, Lu, Jin jian. Paraptosis: a non-classical paradigm of cell death for cancer therapy[J]. Acta Pharmacologica Sinica, 2024, 45(2), 223-237.
Authors:  Xu, Chun cao;  Lin, Yi fan;  Huang, Mu yang;  Zhang, Xiao lei;  Wang, Pei; et al.
Favorite | TC[WOS]:21 TC[Scopus]:19  IF:6.9/7.6 | Submit date：2024/05/16
cancer therapy  endoplasmic reticulum  ER stress  mitochondria  paraptosis  
Paraptosis: a non-classical paradigm of cell death for cancer therapy Review article
2024
Authors:  Xu, Chun cao;  Lin, Yi fan;  Huang, Mu yang;  Zhang, Xiao lei;  Wang, Pei; et al.
Favorite | TC[WOS]:21 TC[Scopus]:19  IF:6.9/7.6 | Submit date：2024/02/22
Cancer Therapy  Endoplasmic Reticulum  Er Stress  Mitochondria  Paraptosis  
Celastrol attenuates hepatitis C virus translation and inflammatory response in mice by suppressing heat shock protein 90β Journal article
Shao-Ru Chen, Zheng-Qing Li, Jun Xu, Mo-Yu Ding, Yaming Shan, Yung-Chi Cheng, Gao-Xiao Zhang, Ye-Wei Sun, Yuqiang Wang, Wang Y(王穎). Celastrol attenuates hepatitis C virus translation and inflammatory response in mice by suppressing heat shock protein 90β[J]. ACTA PHARMACOLOGICA SINICA, 2023, 44, 1637-1648.
Authors:  Shao-Ru Chen;  Zheng-Qing Li;  Jun Xu;  Mo-Yu Ding;  Yaming Shan; et al.
Favorite | TC[WOS]:8 TC[Scopus]:10  IF:6.9/7.6 | Submit date：2023/07/06
Celastrol  Heat Shock Protein 90β  Hepatitis c Virus  Inflammatory Response  Rna-dependent Rna Polymerase  
Corynoxine B derivative CB6 prevents Parkinsonian toxicity in mice by inducing PIK3C3 complex-dependent autophagy Journal article
Zhu, Zhou, Liu, Liang feng, Su, Cheng fu, Liu, Jia, Tong, Benjamin Chun Kit, Iyaswamy, Ashok, Krishnamoorthi, Senthilkumar, Sreenivasmurthy, Sravan Gopalkrishnashetty, Guan, Xin jie, Kan, Yu xuan, Xie, Wen jian, Zhao, Chen liang, Cheung, King ho, Lu, Jia hong, Tan, Jie qiong, Zhang, Hong jie, Song, Ju xian, Li, Min. Corynoxine B derivative CB6 prevents Parkinsonian toxicity in mice by inducing PIK3C3 complex-dependent autophagy[J]. Acta Pharmacologica Sinica, 2022, 43(10), 2511-2526.
Authors:  Zhu, Zhou;  Liu, Liang feng;  Su, Cheng fu;  Liu, Jia;  Tong, Benjamin Chun Kit; et al.
Favorite | TC[WOS]:24 TC[Scopus]:21  IF:6.9/7.6 | Submit date：2022/05/17
Autophagy  Corynoxine b  Dopaminergic Neuron