Effect of GMCSF-absence on neovascularization during wound healing

Residential College	false
Status	已發表Published
	Effect of GMCSF-absence on neovascularization during wound healing
	Fang Y.; Gong S.J.; Wang Y.; Xu Y.H.; Bao S.S.
	2007-05-01
Source Publication	Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery
ISSN	10094598
Volume	23 Issue:3 Pages:233-235
Abstract	OBJECTIVE: To study the effect of GMCSF-absence on the rate of wound healing and neovascularization during wound repair. METHODS: 30 wild type (WT) mice and 30 GMCSF- absence mice (GMCSF-KO) were obtained. They were received full thickness skin wound (0.8 cm x 0.8 cm) in each side of midline after deeply anesthesia. In the different post-injury time points, the wound sites were digitally photographed to calculate the percentage of wound closure by using computer image analyses software. The wound specimens were also obtained dynamically for immunohistological analysis of CD31 at wound site. RESULTS: The analysis of the wound closure showed that wound healing in GMCSF-KO mice was delayed significantly comparing with that in WT mice from the day 3 post-wounding. At days 7 and 10 after wounding significantly more numbers of blood vessels were formed in the WT controls compared to the GMCSF-KO mice. CONCLUSIONS: GMCSF-absence inhibits neovascularization during wound repair and leads to the delay of wound healing.
URL	View the original
Language	英語English
Fulltext Access	View Full-Text via Scopus
Document Type	Journal article
Collection	University of Macau
Affiliation	Shanghai Jiao Tong University School of Medicine
Recommended Citation GB/T 7714	Fang Y.,Gong S.J.,Wang Y.,et al. Effect of GMCSF-absence on neovascularization during wound healing[J]. Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery, 2007, 23(3), 233-235.
APA	Fang Y.., Gong S.J.., Wang Y.., Xu Y.H.., & Bao S.S. (2007). Effect of GMCSF-absence on neovascularization during wound healing. Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery, 23(3), 233-235.
MLA	Fang Y.,et al."Effect of GMCSF-absence on neovascularization during wound healing".Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery 23.3(2007):233-235.

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