Frequency of the CD4+CD25nt/hiCD127lo regulatory T lymphocytes from the peripheral blood in Chinese healthy individuals

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	Frequency of the CD4+CD25nt/hiCD127lo regulatory T lymphocytes from the peripheral blood in Chinese healthy individuals
	Wang Y.; Zhou L.M.; Gong J.L.; Zhou M.K.; Shen F.W.; Zheng X.H.; Zhang W.; Zhuang M.H.; Lu W.; Zhong P.; Pan Q.C.; Kang L.Y.
	2007-09-01
Source Publication	Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology
ISSN	10078738
Volume	23 Issue:9 Pages:816-818
Abstract	AIM: To determine the frequency of the CD4(+)CD25(nt/hi)CD127(lo) regulatory T lymphocytes from the peripheral blood in the Chinese healthy individuals and provide some useful evidence for clinical research of correlative diseases. METHODS: From the CD4(+)CD25(nt/hi)CD127(lo) regulatory T lymphocytes of peripheral blood in 312 Chinese healthy male and female individuals aged from 8 to 60(five age groups were collected) The expression of transcription factor Foxp3 was detected by triplex immuno fluorescence and the frequency of CD4(+)CD25(nt/hi)CD127(lo) regulatory T lymphocytes was determined by flow cytometry. RESULTS: The frequency of CD4(+)CD25(nt/hi)CD127(lo) regulatory T lymphocytes in Chinese healthy individuals was (6.55+/-0.11)%, and the frequency differed among age groups(P=0.015) and sex groups(P<0.05). CD4(+)CD25(nt/hi)CD127(lo) regulatory T lymphocytes specifically express transcription factor Foxp3. CONCLUSION: The frequency of the CD4(+)CD25(nt/hi)CD127(lo) regulatory T lymphocytes from the peripheral blood in the Chinese healthy individuals has been preliminarily determined which lays the foundation for further clinical research of regulatory T lymphocytes. As a specific cell surface marker, CD25(nt/hi)CD127(lo) can helpful obtain pure CD4(+)CD25(+) regulatory T lymphocytes and suppress the interference of other cells during cell separation.
URL	View the original
Language	英語English
Fulltext Access	View Full-Text via Scopus
Document Type	Journal article
Collection	University of Macau
Affiliation	Shanghai Municipal Center for AIDS Research Director
Recommended Citation GB/T 7714	Wang Y.,Zhou L.M.,Gong J.L.,et al. Frequency of the CD4+CD25nt/hiCD127lo regulatory T lymphocytes from the peripheral blood in Chinese healthy individuals[J]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2007, 23(9), 816-818.
APA	Wang Y.., Zhou L.M.., Gong J.L.., Zhou M.K.., Shen F.W.., Zheng X.H.., Zhang W.., Zhuang M.H.., Lu W.., Zhong P.., Pan Q.C.., & Kang L.Y. (2007). Frequency of the CD4+CD25nt/hiCD127lo regulatory T lymphocytes from the peripheral blood in Chinese healthy individuals. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 23(9), 816-818.
MLA	Wang Y.,et al."Frequency of the CD4+CD25nt/hiCD127lo regulatory T lymphocytes from the peripheral blood in Chinese healthy individuals".Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 23.9(2007):816-818.

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