| Residential College | false |
| Status | 已發表Published |
| The significance of combining VEGFa, FLT1 and KDR expressions in colon cancer patient prognosis and predicting response to bevacizumab | |
Zhang, S.D.; McCrudden, C.M.; Meng, C.; Lin, Y. ; Kwok, H. F.
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| 2015-04-15 | |
| Source Publication | Oncotargets & Therapy
 |
| ISSN | 1178-6930 |
| Pages | 835-843 |
| Abstract | Targeting angiogenesis through inhibition of the vascular endothelial growth factor (VEGF) pathway has been successful in the treatment of late stage colorectal cancer. However, not all patients benefit from inhibition of VEGF. Ras status is a powerful biomarker for response to anti-EGFR therapy, however, an appropriate biomarker for response to anti-VEGF therapy is yet to be identified. VEGF and its receptors, FLT1 and KDR, play a crucial role in colon cancer progression; individually, these factors have been shown to be prognostic in colon cancer, however, expression of none of these factors alone was predictive of tumor response to anti-VEGF therapy. In the present study, we analyzed the expression levels of VEGFa, FLT1 and KDR in two independent colon cancer datasets and found that high expression levels of all three factors afforded a very poor prognosis. The observation was further confirmed in another independent colon cancer dataset, wherein high level expression of this 3-gene signature was predictive of poor prognosis in patients with proficient MMR, wild-type KRas status or mutant p53 status. Most importantly, this signature also predicted tumor response to bevacizumab, an antibody targeting VEGFa, in a cohort of bevacizumab-treated patients. Since bevacizumab has been proven to be an important drug in treatment of advanced stage colon cancer, our results suggest that the 3-gene signature approach is valuable in terms of its prognostic value, and that it should be further evaluated in a prospective clinical trial to investigate its predictive value to anti-VEGF treatment. |
| Keyword | Colon cancer VEGFa FLT1 KDR Angiogenesis Survival |
| URL | View the original |
| Language | 英語English |
| The Source to Article | PB_Publication |
| PUB ID | 13826 |
| Document Type | Journal article |
| Collection | DEPARTMENT OF BIOMEDICAL SCIENCES |
| Corresponding Author | Lin, Y.; Kwok, H. F. |
| Recommended Citation GB/T 7714 | Zhang, S.D.,McCrudden, C.M.,Meng, C.,et al. The significance of combining VEGFa, FLT1 and KDR expressions in colon cancer patient prognosis and predicting response to bevacizumab[J]. Oncotargets & Therapy, 2015, 835-843. |
| APA | Zhang, S.D.., McCrudden, C.M.., Meng, C.., Lin, Y.., & Kwok, H. F. (2015). The significance of combining VEGFa, FLT1 and KDR expressions in colon cancer patient prognosis and predicting response to bevacizumab. Oncotargets & Therapy, 835-843. |
| MLA | Zhang, S.D.,et al."The significance of combining VEGFa, FLT1 and KDR expressions in colon cancer patient prognosis and predicting response to bevacizumab".Oncotargets & Therapy (2015):835-843. |
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