| Residential College | false |
| Status | 已發表Published |
| CD133 in brain tumor: the prognostic significance factor | |
Li, B. ; McCrudden, C. M.; Yuen, H. F.; Xi, X.; Peng, P.; Chan, K. W.; Zhang, S. D.; Kwok, H. F.
| |
| 2016-12-31 | |
| Source Publication | Oncotarget
 |
| ISSN | 1949-2553 |
| Pages | 11144-11159 |
| Abstract | CD133 has been shown to be an important stem cell factor that promotes glioma progression. However, the mechanism for CD133-mediated glioma progression has yet to be fully elucidated. In this study, we found that CD133 mRNA expression was a prognostic marker in three independent glioma patient cohorts, corroborating a putative role for CD133 in glioma progression. Importantly, we found that CD133 expression in glioma was highly correlated with the expression of HOX gene stem cell factors (HOXA5, HOXA7, HOXA10, HOXC4 and HOXC6) . The expression of these HOX genes by itself was also significantly associated with survival. Interestingly, the prognostic significance of CD133 was dependent on the expression level of HOX genes, and vice versa. CD133 (p = 0.034) and HOXA7 (p < 0.001) were independent prognostic markers when the three glioma patient cohorts were combined (n = 242). These results suggest that HOX genes may play a more important role in progression of glioma when CD133 expression is low. Furthermore, we identified that low-level expression of LIM2 in CD133-high glioma was associated with poorer survival, suggesting that LIM2 could be a therapeutic target for glioma expressing a high level of CD133. Importantly, we have identified that vinblastine and vincristine could reve |
| Keyword | Brain tumor CD133 HOX LIM2 Stem cell Survival |
| URL | View the original |
| Language | 英語English |
| The Source to Article | PB_Publication |
| PUB ID | 20002 |
| Document Type | Journal article |
| Collection | DEPARTMENT OF BIOMEDICAL SCIENCES |
| Corresponding Author | Kwok, H. F. |
| Recommended Citation GB/T 7714 | Li, B.,McCrudden, C. M.,Yuen, H. F.,et al. CD133 in brain tumor: the prognostic significance factor[J]. Oncotarget, 2016, 11144-11159. |
| APA | Li, B.., McCrudden, C. M.., Yuen, H. F.., Xi, X.., Peng, P.., Chan, K. W.., Zhang, S. D.., & Kwok, H. F. (2016). CD133 in brain tumor: the prognostic significance factor. Oncotarget, 11144-11159. |
| MLA | Li, B.,et al."CD133 in brain tumor: the prognostic significance factor".Oncotarget (2016):11144-11159. |
| Files in This Item: | There are no files associated with this item. | |||||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment